| Name | PLCB3 |
| ID | Q01970 |
| Role | substrate |
| Enzymatic Domains |
PI-PLC X-box 318-468 PROSITE-ProRule
PI-PLC Y-box 590-706 PROSITE-ProRule
C2 707-835 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKG2 | PLCB3 | Ser26 | VETLRRGsKFIKWDE | phosphorylation down-regulates activity | 11278298 | SIGNOR-249080 |
| PRKG1 | PLCB3 | Ser26 | VETLRRGsKFIKWDE | phosphorylation down-regulates activity | 11278298 | SIGNOR-249079 |
| CAMK2B | PLCB3 | Ser537 | PSLEPQKsLGDEGLN | phosphorylation unknown | 11325525 | SIGNOR-250689 |
| MAP3K8 | PLCB3 | Ser537 | PSLEPQKsLGDEGLN | phosphorylation up-regulates activity | 21868363 | SIGNOR-278519 |
| PRKACA | PLCB3 | Ser1105 | LDRKRHNsISEAKMR | phosphorylation down-regulates | 10893237 | SIGNOR-79148 |
| PRKG2 | PLCB3 | Ser1105 | LDRKRHNsISEAKMR | phosphorylation down-regulates activity | 11278298 | SIGNOR-249078 |
| PRKG1 | PLCB3 | Ser1105 | LDRKRHNsISEAKMR | phosphorylation down-regulates activity | 11278298 | SIGNOR-249077 |
| CAMK2G | PLCB3 | Ser537 | PSLEPQKsLGDEGLN | phosphorylation unknown | 11325525 | SIGNOR-250702 |
| PRKCA | PLCB3 | Ser1105 | LDRKRHNsISEAKMR | phosphorylation down-regulates | 9660757 | SIGNOR-58859 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKG2 | phosphorylation up-regulates → | PLCB3 PSer26 | phosphorylation down-regulates ⊣ | PLCB3 | 11278298 | SIGNOR-249080 |
| PRKG1 | phosphorylation up-regulates → | PLCB3 PSer26 | phosphorylation down-regulates ⊣ | PLCB3 | 11278298 | SIGNOR-249079 |
| CAMK2B | phosphorylation up-regulates → | PLCB3 PSer537 | phosphorylation down-regulates ⊣ | PLCB3 | 11325525 | SIGNOR-250689 |
| MAP3K8 | phosphorylation up-regulates → | PLCB3 PSer537 | phosphorylation up-regulates → | PLCB3 | 21868363 | SIGNOR-278519 |
| PRKACA | phosphorylation up-regulates → | PLCB3 PSer1105 | phosphorylation down-regulates ⊣ | PLCB3 | 10893237 | SIGNOR-79148 |
| PRKG2 | phosphorylation up-regulates → | PLCB3 PSer1105 | phosphorylation down-regulates ⊣ | PLCB3 | 11278298 | SIGNOR-249078 |
| PRKG1 | phosphorylation up-regulates → | PLCB3 PSer1105 | phosphorylation down-regulates ⊣ | PLCB3 | 11278298 | SIGNOR-249077 |
| CAMK2G | phosphorylation up-regulates → | PLCB3 PSer537 | phosphorylation down-regulates ⊣ | PLCB3 | 11325525 | SIGNOR-250702 |
| PRKCA | phosphorylation up-regulates → | PLCB3 PSer1105 | phosphorylation down-regulates ⊣ | PLCB3 | 9660757 | SIGNOR-58859 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKG2 | phosphorylation → down-regulates activity | PLCB3 | SIGNOR-249080 |
| PRKG1 | phosphorylation → down-regulates activity | PLCB3 | SIGNOR-249079 |
| CAMK2B | phosphorylation → unknown | PLCB3 | SIGNOR-250689 |
| MAP3K8 | phosphorylation → up-regulates activity | PLCB3 | SIGNOR-278519 |
| PRKACA | phosphorylation down-regulates | PLCB3 | SIGNOR-79148 |
| PRKG2 | phosphorylation → down-regulates activity | PLCB3 | SIGNOR-249078 |
| PRKG1 | phosphorylation → down-regulates activity | PLCB3 | SIGNOR-249077 |
| CAMK2G | phosphorylation → unknown | PLCB3 | SIGNOR-250702 |
| PRKCA | phosphorylation down-regulates | PLCB3 | SIGNOR-58859 |