| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCA | PLCB3 | Ser1105 | LDRKRHNsISEAKMR | phosphorylation down-regulates | 9660757 | SIGNOR-58859 |
| PRKACA | PLCB3 | Ser1105 | LDRKRHNsISEAKMR | phosphorylation down-regulates | 10893237 | SIGNOR-79148 |
| PRKG2 | PLCB3 | Ser1105 | LDRKRHNsISEAKMR | phosphorylation down-regulates activity | 11278298 | SIGNOR-249078 |
| PRKG1 | PLCB3 | Ser1105 | LDRKRHNsISEAKMR | phosphorylation down-regulates activity | 11278298 | SIGNOR-249077 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCA | phosphorylation up-regulates → | PLCB3 PSer1105 | phosphorylation down-regulates ⊣ | PLCB3 | 9660757 | SIGNOR-58859 |
| PRKACA | phosphorylation up-regulates → | PLCB3 PSer1105 | phosphorylation down-regulates ⊣ | PLCB3 | 10893237 | SIGNOR-79148 |
| PRKG2 | phosphorylation up-regulates → | PLCB3 PSer1105 | phosphorylation down-regulates ⊣ | PLCB3 | 11278298 | SIGNOR-249078 |
| PRKG1 | phosphorylation up-regulates → | PLCB3 PSer1105 | phosphorylation down-regulates ⊣ | PLCB3 | 11278298 | SIGNOR-249077 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKCA | phosphorylation down-regulates | PLCB3 | SIGNOR-58859 |
| PRKACA | phosphorylation down-regulates | PLCB3 | SIGNOR-79148 |
| PRKG2 | phosphorylation → down-regulates activity | PLCB3 | SIGNOR-249078 |
| PRKG1 | phosphorylation → down-regulates activity | PLCB3 | SIGNOR-249077 |
