| Name | ROR2 |
| ID | Q01974 |
| Role | substrate |
| Enzymatic Domains |
Ig-like C2-type 55-145
FZ 169-303 PROSITE-ProRule
Kringle 316-394 PROSITE-ProRule
Protein kinase 473-746 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3B | ROR2 | Ser864 | PKPSSHHsGSGSTST | phosphorylation down-regulates activity | 21078818 | SIGNOR-169642 |
| CSNK1E | ROR2 | – | phosphorylation up-regulates | 15375164 | SIGNOR-129117 | |
| GSK3B/Axin/APC | ROR2 | Ser864 | PKPSSHHsGSGSTST | phosphorylation down-regulates activity | 21078818 | SIGNOR-228026 |
| TAB1 | ROR2 | – | phosphorylation down-regulates | 18762249 | SIGNOR-180566 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3B | phosphorylation up-regulates → | ROR2 PSer864 | phosphorylation down-regulates ⊣ | ROR2 | 21078818 | SIGNOR-169642 |
| GSK3B/Axin/APC | phosphorylation up-regulates → | ROR2 PSer864 | phosphorylation down-regulates ⊣ | ROR2 | 21078818 | SIGNOR-228026 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| GSK3B | phosphorylation → down-regulates activity | ROR2 | SIGNOR-169642 |
| CSNK1E | phosphorylation → up-regulates | ROR2 | SIGNOR-129117 |
| GSK3B/Axin/APC | phosphorylation → down-regulates activity | ROR2 | SIGNOR-228026 |
| TAB1 | phosphorylation down-regulates | ROR2 | SIGNOR-180566 |