| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CyclinE/CDK2 | ID2 | Ser5 | sPVRSVRK | phosphorylation down-regulates | 9029153 | SIGNOR-216698 |
| CyclinA2/CDK2 | ID2 | Ser5 | sPVRSVRK | phosphorylation down-regulates | 9029153 | SIGNOR-217320 |
| CDK2 | ID2 | Ser5 | sPVRSVRK | phosphorylation down-regulates | 9029153 | SIGNOR-46397 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CyclinE/CDK2 | phosphorylation up-regulates → | ID2 PSer5 | phosphorylation down-regulates ⊣ | ID2 | 9029153 | SIGNOR-216698 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | ID2 PSer5 | phosphorylation down-regulates ⊣ | ID2 | 9029153 | SIGNOR-217320 |
| CDK2 | phosphorylation up-regulates → | ID2 PSer5 | phosphorylation down-regulates ⊣ | ID2 | 9029153 | SIGNOR-46397 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CyclinE/CDK2 | phosphorylation![]() down-regulates | ID2 | SIGNOR-216698 |
| CyclinA2/CDK2 | phosphorylation![]() down-regulates | ID2 | SIGNOR-217320 |
| CDK2 | phosphorylation![]() down-regulates | ID2 | SIGNOR-46397 |