Entity Details

Name SP3
ID Q02447
Role substrate
Enzymatic Domains
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
ERK1/2SP3–phosphorylation
up-regulates		17685427SIGNOR-270165
PPP1CASP3–dephosphorylation
down-regulates activity		12684058SIGNOR-251953
MAPK1SP3Ser73
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CSKIGPPsPGDDEEEphosphorylation
up-regulates		17685427SIGNOR-157272
GbetaSP3–phosphorylation
up-regulates		17685427SIGNOR-270053
MAPK3SP3Ser73
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CSKIGPPsPGDDEEEphosphorylation
up-regulates		17685427SIGNOR-157276
PP1SP3–dephosphorylation
down-regulates activity		12684058SIGNOR-264652
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
MAPK1phosphorylation
up-regulates
→
SP3
PSer73		phosphorylation
up-regulates
→		SP317685427SIGNOR-157272
MAPK3phosphorylation
up-regulates
→
SP3
PSer73		phosphorylation
up-regulates
→		SP317685427SIGNOR-157276
Regulator Mechanism/Effect Target SIGNOR-ID
ERK1/2phosphorylation
→
up-regulates 		SP3SIGNOR-270165
PPP1CAdephosphorylation
→
down-regulates activity 		SP3SIGNOR-251953
MAPK1phosphorylation
→
up-regulates 		SP3SIGNOR-157272
Gbetaphosphorylation
→
up-regulates 		SP3SIGNOR-270053
MAPK3phosphorylation
→
up-regulates 		SP3SIGNOR-157276
PP1dephosphorylation
→
down-regulates activity 		SP3SIGNOR-264652