Entity Details

Name	SP3
ID	Q02447
Role	substrate
Enzymatic Domains
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Data Summary

PTM Format

SIGNOR Summary

Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
PPP1CA	SP3	–		dephosphorylation down-regulates activity	12684058	SIGNOR-251953
MAPK3	SP3	Ser73 View in OncoXplorer	CSKIGPPsPGDDEEE	phosphorylation up-regulates	17685427	SIGNOR-157276
Gbeta	SP3	–		phosphorylation up-regulates	17685427	SIGNOR-270053
ERK1/2	SP3	–		phosphorylation up-regulates	17685427	SIGNOR-270165
MAPK1	SP3	Ser73 View in OncoXplorer	CSKIGPPsPGDDEEE	phosphorylation up-regulates	17685427	SIGNOR-157272
PP1	SP3	–		dephosphorylation down-regulates activity	12684058	SIGNOR-264652

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
MAPK3	phosphorylation up-regulates →	SP3 PSer73	phosphorylation up-regulates →	SP3	17685427	SIGNOR-157276
MAPK1	phosphorylation up-regulates →	SP3 PSer73	phosphorylation up-regulates →	SP3	17685427	SIGNOR-157272

Regulator	Mechanism/Effect	Target	SIGNOR-ID
PPP1CA	dephosphorylation → down-regulates activity	SP3	SIGNOR-251953
MAPK3	phosphorylation → up-regulates	SP3	SIGNOR-157276
Gbeta	phosphorylation → up-regulates	SP3	SIGNOR-270053
ERK1/2	phosphorylation → up-regulates	SP3	SIGNOR-270165
MAPK1	phosphorylation → up-regulates	SP3	SIGNOR-157272
PP1	dephosphorylation → down-regulates activity	SP3	SIGNOR-264652