| Name | MAP2K1 |
| ID | Q02750 |
| Role | kinase |
| Enzymatic Domains |
Protein kinase 68-361 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAP2K1 | RAF1 | Ser338 | RPRGQRDsSYYWEIE | phosphorylation up-regulates activity | 23360980 | SIGNOR-279627 |
| MAP2K1 | TAL1 | Ser122 | DGRMVQLsPPALAAP | phosphorylation down-regulates | 11904294 | SIGNOR-116149 |
| MAP2K1 | MAPK3 | – | phosphorylation up-regulates | 12270934 | SIGNOR-210176 | |
| MAP2K1 | MAPK3 | Thr202 | HDHTGFLtEYVATRW | phosphorylation up-regulates | 9677429 | SIGNOR-59153 |
| MAP2K1 | MAPK3 | Tyr204 | HTGFLTEyVATRWYR | phosphorylation up-regulates | 9677429 | SIGNOR-59157 |
| MAP2K1 | MAPK3 | – | phosphorylation up-regulates activity | 11730323 | SIGNOR-258994 | |
| MAP2K1 | MAPK1 | – | phosphorylation up-regulates activity | 11730323 | SIGNOR-258993 | |
| MAP2K1 | MAPK1 | Thr185 | HDHTGFLtEYVATRW | phosphorylation up-regulates activity | 11971971 | SIGNOR-236447 |
| MAP2K1 | MAPK1 | Tyr187 | HTGFLTEyVATRWYR | phosphorylation up-regulates activity | 11971971 | SIGNOR-235937 |
| MAP2K1 | MAPK1 | – | phosphorylation up-regulates activity | 12270934 | SIGNOR-235940 | |
| MAP2K1 | ARRB2 | Thr382 | EFDTNYAtDDDIVFE | phosphorylation up-regulates activity | 28169830 | SIGNOR-252027 |
| MAP2K1 | IRS1 | Ser307 | TRRSRTEsITATSPA | phosphorylation down-regulates | 11160134 | SIGNOR-236611 |
| MAP2K1 | GSK3B | Tyr216 | RGEPNVSyICSRYYR | phosphorylation up-regulates activity | 15020233 | SIGNOR-236622 |
| MAP2K1 | CASP9 | Thr125 | PEVLRPEtPRPVDIG | phosphorylation down-regulates activity | 12792650 | SIGNOR-249385 |
| MAP2K1 | HSF1 | Ser241 | VHGSGPYsAPSPAYS | phosphorylation up-regulates activity | 35080342 | SIGNOR-279208 |
| MAP2K1 | HSF1 | Ser326 | SSVDTLLsPTALIDS | phosphorylation up-regulates activity | 35080342 | SIGNOR-279209 |
| MAP2K1 | HSF1 | Ser344 | ESEPAPAsVTALTDA | phosphorylation up-regulates activity | 35080342 | SIGNOR-279210 |
| MAP2K1 | HSF1 | Ser363 | DTEGRPPsPPPTSTP | phosphorylation up-regulates activity | 35080342 | SIGNOR-279211 |
| MAP2K1 | MYT1 | – | phosphorylation down-regulates activity | 23241949 | SIGNOR-279052 | |
| MAP2K1 | MAP2K1 | Ser304 | LSSYGMDsRPPMAIF | phosphorylation up-regulates activity | 8226933 | SIGNOR-251415 |
| MAP2K1 | TET2 | Ser1107 | VLNNFIEsPSKLLDT | phosphorylation up-regulates quantity by stabilization | 38461173 | SIGNOR-277891 |
| MAP2K1 | MYRF | – | phosphorylation down-regulates activity | 30496175 | SIGNOR-279416 | |
| MAP2K1 | ERK1/2 | – | phosphorylation up-regulates activity | 11730323 | SIGNOR-258992 | |
| MAP2K1 | ERK1/2 | – | phosphorylation up-regulates activity | 12270934 | SIGNOR-235352 | |
| MAP2K1 | Gbeta | – | phosphorylation up-regulates | 12270934 | SIGNOR-269909 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAP2K1 | phosphorylation up-regulates → | RAF1 PSer338 | phosphorylation up-regulates → | RAF1 | 23360980 | SIGNOR-279627 |
| MAP2K1 | phosphorylation up-regulates → | TAL1 PSer122 | phosphorylation down-regulates ⊣ | TAL1 | 11904294 | SIGNOR-116149 |
| MAP2K1 | phosphorylation up-regulates → | MAPK3 PThr202 | phosphorylation up-regulates → | MAPK3 | 9677429 | SIGNOR-59153 |
| MAP2K1 | phosphorylation up-regulates → | MAPK3 PTyr204 | phosphorylation up-regulates → | MAPK3 | 9677429 | SIGNOR-59157 |
| MAP2K1 | phosphorylation up-regulates → | MAPK1 PThr185 | phosphorylation up-regulates → | MAPK1 | 11971971 | SIGNOR-236447 |
| MAP2K1 | phosphorylation up-regulates → | MAPK1 PTyr187 | phosphorylation up-regulates → | MAPK1 | 11971971 | SIGNOR-235937 |
| MAP2K1 | phosphorylation up-regulates → | ARRB2 PThr382 | phosphorylation up-regulates → | ARRB2 | 28169830 | SIGNOR-252027 |
| MAP2K1 | phosphorylation up-regulates → | IRS1 PSer307 | phosphorylation down-regulates ⊣ | IRS1 | 11160134 | SIGNOR-236611 |
| MAP2K1 | phosphorylation up-regulates → | GSK3B PTyr216 | phosphorylation up-regulates → | GSK3B | 15020233 | SIGNOR-236622 |
| MAP2K1 | phosphorylation up-regulates → | CASP9 PThr125 | phosphorylation down-regulates ⊣ | CASP9 | 12792650 | SIGNOR-249385 |
| MAP2K1 | phosphorylation up-regulates → | HSF1 PSer241 | phosphorylation up-regulates → | HSF1 | 35080342 | SIGNOR-279208 |
| MAP2K1 | phosphorylation up-regulates → | HSF1 PSer326 | phosphorylation up-regulates → | HSF1 | 35080342 | SIGNOR-279209 |
| MAP2K1 | phosphorylation up-regulates → | HSF1 PSer344 | phosphorylation up-regulates → | HSF1 | 35080342 | SIGNOR-279210 |
| MAP2K1 | phosphorylation up-regulates → | HSF1 PSer363 | phosphorylation up-regulates → | HSF1 | 35080342 | SIGNOR-279211 |
| MAP2K1 | phosphorylation up-regulates → | MAP2K1 PSer304 | phosphorylation up-regulates → | MAP2K1 | 8226933 | SIGNOR-251415 |
| MAP2K1 | phosphorylation up-regulates → | TET2 PSer1107 | phosphorylation up-regulates → | TET2 | 38461173 | SIGNOR-277891 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAP2K1 | phosphorylation → up-regulates activity | RAF1 | SIGNOR-279627 |
| MAP2K1 | phosphorylation down-regulates | TAL1 | SIGNOR-116149 |
| MAP2K1 | phosphorylation → up-regulates | MAPK3 | SIGNOR-210176 |
| MAP2K1 | phosphorylation → up-regulates | MAPK3 | SIGNOR-59153 |
| MAP2K1 | phosphorylation → up-regulates | MAPK3 | SIGNOR-59157 |
| MAP2K1 | phosphorylation → up-regulates activity | MAPK3 | SIGNOR-258994 |
| MAP2K1 | phosphorylation → up-regulates activity | MAPK1 | SIGNOR-258993 |
| MAP2K1 | phosphorylation → up-regulates activity | MAPK1 | SIGNOR-236447 |
| MAP2K1 | phosphorylation → up-regulates activity | MAPK1 | SIGNOR-235937 |
| MAP2K1 | phosphorylation → up-regulates activity | MAPK1 | SIGNOR-235940 |
| MAP2K1 | phosphorylation → up-regulates activity | ARRB2 | SIGNOR-252027 |
| MAP2K1 | phosphorylation down-regulates | IRS1 | SIGNOR-236611 |
| MAP2K1 | phosphorylation → up-regulates activity | GSK3B | SIGNOR-236622 |
| MAP2K1 | phosphorylation → down-regulates activity | CASP9 | SIGNOR-249385 |
| MAP2K1 | phosphorylation → up-regulates activity | HSF1 | SIGNOR-279208 |
| MAP2K1 | phosphorylation → up-regulates activity | HSF1 | SIGNOR-279209 |
| MAP2K1 | phosphorylation → up-regulates activity | HSF1 | SIGNOR-279210 |
| MAP2K1 | phosphorylation → up-regulates activity | HSF1 | SIGNOR-279211 |
| MAP2K1 | phosphorylation → down-regulates activity | MYT1 | SIGNOR-279052 |
| MAP2K1 | phosphorylation → up-regulates activity | MAP2K1 | SIGNOR-251415 |
| MAP2K1 | phosphorylation → up-regulates quantity by stabilization | TET2 | SIGNOR-277891 |
| MAP2K1 | phosphorylation → down-regulates activity | MYRF | SIGNOR-279416 |
| MAP2K1 | phosphorylation → up-regulates activity | ERK1/2 | SIGNOR-258992 |
| MAP2K1 | phosphorylation → up-regulates activity | ERK1/2 | SIGNOR-235352 |
| MAP2K1 | phosphorylation → up-regulates | Gbeta | SIGNOR-269909 |