| Name | MAP2K1 |
| ID | Q02750 |
| Role | substrate |
| Enzymatic Domains |
Protein kinase 68-361 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| BRAF | MAP2K1 | Ser222 | LIDSMANsFVGTRSY | phosphorylation up-regulates activity | 8413257 | SIGNOR-39054 |
| MAP2K1 | MAP2K1 | Ser304 | LSSYGMDsRPPMAIF | phosphorylation up-regulates activity | 8226933 | SIGNOR-251415 |
| CDK5/CDK5R1 | MAP2K1 | Thr286 | VEGDAAEtPPRPRTP | phosphorylation down-regulates activity | 11684694 | SIGNOR-250653 |
| MAP3K8 | MAP2K1 | Ser222 | LIDSMANsFVGTRSY | phosphorylation up-regulates | 8131746 | SIGNOR-36449 |
| RAF1 | MAP2K1 | Ser222 | LIDSMANsFVGTRSY | phosphorylation up-regulates activity | 10359597 | SIGNOR-235991 |
| CDK1 | MAP2K1 | Thr286 | VEGDAAEtPPRPRTP | phosphorylation down-regulates | 8114697 | SIGNOR-36112 |
| ARAF | MAP2K1 | Ser222 | LIDSMANsFVGTRSY | phosphorylation up-regulates | 8621729 | SIGNOR-235944 |
| MAP3K8 | MAP2K1 | Ser218 | VSGQLIDsMANSFVG | phosphorylation up-regulates | 15466476 | SIGNOR-129690 |
| RAF1 | MAP2K1 | Ser218 | VSGQLIDsMANSFVG | phosphorylation up-regulates activity | 10359597 | SIGNOR-235987 |
| ERK1/2 | MAP2K1 | Thr292 | ETPPRPRtPGRPLSS | phosphorylation down-regulates activity | 14993270 | SIGNOR-244557 |
| PDPK1 | MAP2K1 | Ser222 | LIDSMANsFVGTRSY | phosphorylation up-regulates activity | 15175348 | SIGNOR-236633 |
| MAP3K8 | MAP2K1 | Ser244 | GTHYSVQsDIWSMGL | phosphorylation up-regulates | 8131746 | SIGNOR-36453 |
| PAK | MAP2K1 | Ser298 | RTPGRPLsSYGMDSR | phosphorylation up-regulates | 16129686 | SIGNOR-140039 |
| MOS | MAP2K1 | Ser222 | LIDSMANsFVGTRSY | phosphorylation up-regulates activity | 7731726 | SIGNOR-260920 |
| MAPK1 | MAP2K1 | Thr292 | ETPPRPRtPGRPLSS | phosphorylation down-regulates activity | 14993270 | SIGNOR-236335 |
| PAK1 | MAP2K1 | Ser298 | RTPGRPLsSYGMDSR | phosphorylation up-regulates activity | 12876277 | SIGNOR-236002 |
| ERK1/2 | MAP2K1 | Thr386 | IGLNQPStPTHAAGV | phosphorylation down-regulates activity | 10567369 | SIGNOR-244561 |
| MAP3K2 | MAP2K1 | – | phosphorylation up-regulates | 11343802 | SIGNOR-107692 | |
| ARAF | MAP2K1 | Ser218 | VSGQLIDsMANSFVG | phosphorylation up-regulates | 8621729 | SIGNOR-236451 |
| MAPK1 | MAP2K1 | Thr386 | IGLNQPStPTHAAGV | phosphorylation down-regulates activity | 10567369 | SIGNOR-236498 |
| MAP3K1 | MAP2K1 | Ser222 | LIDSMANsFVGTRSY | phosphorylation up-regulates activity | 8131746 | SIGNOR-235564 |
| MAP3K1 | MAP2K1 | Ser218 | VSGQLIDsMANSFVG | phosphorylation up-regulates activity | 8131746 | SIGNOR-235587 |
| BRAF | MAP2K1 | Ser252 | DIWSMGLsLVEMAVG | phosphorylation up-regulates activity | 8413257 | SIGNOR-39062 |
| BRAF | MAP2K1 | Ser248 | SVQSDIWsMGLSLVE | phosphorylation up-regulates activity | 8413257 | SIGNOR-39058 |
| BRAF | MAP2K1 | Ser218 | VSGQLIDsMANSFVG | phosphorylation up-regulates activity | 8131746 | SIGNOR-235475 |
| PPP2CA | MAP2K1 | – | dephosphorylation down-regulates | 20626350 | SIGNOR-166649 | |
| MAP3K8 | MAP2K1 | Ser248 | SVQSDIWsMGLSLVE | phosphorylation up-regulates | 8131746 | SIGNOR-36457 |
| MAP3K21 | MAP2K1 | Ser218 | VSGQLIDsMANSFVG | phosphorylation up-regulates activity | 23319808 | SIGNOR-260767 |
| MAP3K11 | MAP2K1 | – | phosphorylation up-regulates activity | 12738796 | SIGNOR-280019 | |
| MAP3K21 | MAP2K1 | Ser222 | LIDSMANsFVGTRSY | phosphorylation up-regulates activity | 23319808 | SIGNOR-260768 |
| CDK1 | MAP2K1 | Thr292 | ETPPRPRtPGRPLSS | phosphorylation down-regulates | 8114697 | SIGNOR-36116 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| BRAF | phosphorylation up-regulates → | MAP2K1 PSer222 | phosphorylation up-regulates → | MAP2K1 | 8413257 | SIGNOR-39054 |
| MAP2K1 | phosphorylation up-regulates → | MAP2K1 PSer304 | phosphorylation up-regulates → | MAP2K1 | 8226933 | SIGNOR-251415 |
| CDK5/CDK5R1 | phosphorylation up-regulates → | MAP2K1 PThr286 | phosphorylation down-regulates ⊣ | MAP2K1 | 11684694 | SIGNOR-250653 |
| MAP3K8 | phosphorylation up-regulates → | MAP2K1 PSer222 | phosphorylation up-regulates → | MAP2K1 | 8131746 | SIGNOR-36449 |
| RAF1 | phosphorylation up-regulates → | MAP2K1 PSer222 | phosphorylation up-regulates → | MAP2K1 | 10359597 | SIGNOR-235991 |
| CDK1 | phosphorylation up-regulates → | MAP2K1 PThr286 | phosphorylation down-regulates ⊣ | MAP2K1 | 8114697 | SIGNOR-36112 |
| ARAF | phosphorylation up-regulates → | MAP2K1 PSer222 | phosphorylation up-regulates → | MAP2K1 | 8621729 | SIGNOR-235944 |
| MAP3K8 | phosphorylation up-regulates → | MAP2K1 PSer218 | phosphorylation up-regulates → | MAP2K1 | 15466476 | SIGNOR-129690 |
| RAF1 | phosphorylation up-regulates → | MAP2K1 PSer218 | phosphorylation up-regulates → | MAP2K1 | 10359597 | SIGNOR-235987 |
| ERK1/2 | phosphorylation up-regulates → | MAP2K1 PThr292 | phosphorylation down-regulates ⊣ | MAP2K1 | 14993270 | SIGNOR-244557 |
| PDPK1 | phosphorylation up-regulates → | MAP2K1 PSer222 | phosphorylation up-regulates → | MAP2K1 | 15175348 | SIGNOR-236633 |
| MAP3K8 | phosphorylation up-regulates → | MAP2K1 PSer244 | phosphorylation up-regulates → | MAP2K1 | 8131746 | SIGNOR-36453 |
| PAK | phosphorylation up-regulates → | MAP2K1 PSer298 | phosphorylation up-regulates → | MAP2K1 | 16129686 | SIGNOR-140039 |
| MOS | phosphorylation up-regulates → | MAP2K1 PSer222 | phosphorylation up-regulates → | MAP2K1 | 7731726 | SIGNOR-260920 |
| MAPK1 | phosphorylation up-regulates → | MAP2K1 PThr292 | phosphorylation down-regulates ⊣ | MAP2K1 | 14993270 | SIGNOR-236335 |
| PAK1 | phosphorylation up-regulates → | MAP2K1 PSer298 | phosphorylation up-regulates → | MAP2K1 | 12876277 | SIGNOR-236002 |
| ERK1/2 | phosphorylation up-regulates → | MAP2K1 PThr386 | phosphorylation down-regulates ⊣ | MAP2K1 | 10567369 | SIGNOR-244561 |
| ARAF | phosphorylation up-regulates → | MAP2K1 PSer218 | phosphorylation up-regulates → | MAP2K1 | 8621729 | SIGNOR-236451 |
| MAPK1 | phosphorylation up-regulates → | MAP2K1 PThr386 | phosphorylation down-regulates ⊣ | MAP2K1 | 10567369 | SIGNOR-236498 |
| MAP3K1 | phosphorylation up-regulates → | MAP2K1 PSer222 | phosphorylation up-regulates → | MAP2K1 | 8131746 | SIGNOR-235564 |
| MAP3K1 | phosphorylation up-regulates → | MAP2K1 PSer218 | phosphorylation up-regulates → | MAP2K1 | 8131746 | SIGNOR-235587 |
| BRAF | phosphorylation up-regulates → | MAP2K1 PSer252 | phosphorylation up-regulates → | MAP2K1 | 8413257 | SIGNOR-39062 |
| BRAF | phosphorylation up-regulates → | MAP2K1 PSer248 | phosphorylation up-regulates → | MAP2K1 | 8413257 | SIGNOR-39058 |
| BRAF | phosphorylation up-regulates → | MAP2K1 PSer218 | phosphorylation up-regulates → | MAP2K1 | 8131746 | SIGNOR-235475 |
| MAP3K8 | phosphorylation up-regulates → | MAP2K1 PSer248 | phosphorylation up-regulates → | MAP2K1 | 8131746 | SIGNOR-36457 |
| MAP3K21 | phosphorylation up-regulates → | MAP2K1 PSer218 | phosphorylation up-regulates → | MAP2K1 | 23319808 | SIGNOR-260767 |
| MAP3K21 | phosphorylation up-regulates → | MAP2K1 PSer222 | phosphorylation up-regulates → | MAP2K1 | 23319808 | SIGNOR-260768 |
| CDK1 | phosphorylation up-regulates → | MAP2K1 PThr292 | phosphorylation down-regulates ⊣ | MAP2K1 | 8114697 | SIGNOR-36116 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| BRAF | phosphorylation → up-regulates activity | MAP2K1 | SIGNOR-39054 |
| MAP2K1 | phosphorylation → up-regulates activity | MAP2K1 | SIGNOR-251415 |
| CDK5/CDK5R1 | phosphorylation → down-regulates activity | MAP2K1 | SIGNOR-250653 |
| MAP3K8 | phosphorylation → up-regulates | MAP2K1 | SIGNOR-36449 |
| RAF1 | phosphorylation → up-regulates activity | MAP2K1 | SIGNOR-235991 |
| CDK1 | phosphorylation down-regulates | MAP2K1 | SIGNOR-36112 |
| ARAF | phosphorylation → up-regulates | MAP2K1 | SIGNOR-235944 |
| MAP3K8 | phosphorylation → up-regulates | MAP2K1 | SIGNOR-129690 |
| RAF1 | phosphorylation → up-regulates activity | MAP2K1 | SIGNOR-235987 |
| ERK1/2 | phosphorylation → down-regulates activity | MAP2K1 | SIGNOR-244557 |
| PDPK1 | phosphorylation → up-regulates activity | MAP2K1 | SIGNOR-236633 |
| MAP3K8 | phosphorylation → up-regulates | MAP2K1 | SIGNOR-36453 |
| PAK | phosphorylation → up-regulates | MAP2K1 | SIGNOR-140039 |
| MOS | phosphorylation → up-regulates activity | MAP2K1 | SIGNOR-260920 |
| MAPK1 | phosphorylation → down-regulates activity | MAP2K1 | SIGNOR-236335 |
| PAK1 | phosphorylation → up-regulates activity | MAP2K1 | SIGNOR-236002 |
| ERK1/2 | phosphorylation → down-regulates activity | MAP2K1 | SIGNOR-244561 |
| MAP3K2 | phosphorylation → up-regulates | MAP2K1 | SIGNOR-107692 |
| ARAF | phosphorylation → up-regulates | MAP2K1 | SIGNOR-236451 |
| MAPK1 | phosphorylation → down-regulates activity | MAP2K1 | SIGNOR-236498 |
| MAP3K1 | phosphorylation → up-regulates activity | MAP2K1 | SIGNOR-235564 |
| MAP3K1 | phosphorylation → up-regulates activity | MAP2K1 | SIGNOR-235587 |
| BRAF | phosphorylation → up-regulates activity | MAP2K1 | SIGNOR-39062 |
| BRAF | phosphorylation → up-regulates activity | MAP2K1 | SIGNOR-39058 |
| BRAF | phosphorylation → up-regulates activity | MAP2K1 | SIGNOR-235475 |
| PPP2CA | dephosphorylation down-regulates | MAP2K1 | SIGNOR-166649 |
| MAP3K8 | phosphorylation → up-regulates | MAP2K1 | SIGNOR-36457 |
| MAP3K21 | phosphorylation → up-regulates activity | MAP2K1 | SIGNOR-260767 |
| MAP3K11 | phosphorylation → up-regulates activity | MAP2K1 | SIGNOR-280019 |
| MAP3K21 | phosphorylation → up-regulates activity | MAP2K1 | SIGNOR-260768 |
| CDK1 | phosphorylation down-regulates | MAP2K1 | SIGNOR-36116 |