| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK5/CDK5R1 | MAP2K1 | Thr286 | VEGDAAEtPPRPRTP | phosphorylation down-regulates activity | 11684694 | SIGNOR-250653 |
| CDK1 | MAP2K1 | Thr286 | VEGDAAEtPPRPRTP | phosphorylation down-regulates | 8114697 | SIGNOR-36112 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK5/CDK5R1 | phosphorylation up-regulates → | MAP2K1 PThr286 | phosphorylation down-regulates ⊣ | MAP2K1 | 11684694 | SIGNOR-250653 |
| CDK1 | phosphorylation up-regulates → | MAP2K1 PThr286 | phosphorylation down-regulates ⊣ | MAP2K1 | 8114697 | SIGNOR-36112 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDK5/CDK5R1 | phosphorylation → down-regulates activity | MAP2K1 | SIGNOR-250653 |
| CDK1 | phosphorylation down-regulates | MAP2K1 | SIGNOR-36112 |
