| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| BRAF | MAP2K1 | Ser248 | SVQSDIWsMGLSLVE | phosphorylation up-regulates activity | 8413257 | SIGNOR-39058 |
| MAP3K8 | MAP2K1 | Ser248 | SVQSDIWsMGLSLVE | phosphorylation up-regulates | 8131746 | SIGNOR-36457 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| BRAF | phosphorylation up-regulates → | MAP2K1 PSer248 | phosphorylation up-regulates → | MAP2K1 | 8413257 | SIGNOR-39058 |
| MAP3K8 | phosphorylation up-regulates → | MAP2K1 PSer248 | phosphorylation up-regulates → | MAP2K1 | 8131746 | SIGNOR-36457 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| BRAF | phosphorylation → up-regulates activity | MAP2K1 | SIGNOR-39058 |
| MAP3K8 | phosphorylation → up-regulates | MAP2K1 | SIGNOR-36457 |