Entity Details

Name RAF1_Ser218
ID Q02750
Role residue
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
MAP3K8MAP2K1Ser218VSGQLIDsMANSFVGphosphorylation
up-regulates		15466476SIGNOR-129690
RAF1MAP2K1Ser218VSGQLIDsMANSFVGphosphorylation
up-regulates activity		10359597SIGNOR-235987
ARAFMAP2K1Ser218VSGQLIDsMANSFVGphosphorylation
up-regulates		8621729SIGNOR-236451
MAP3K1MAP2K1Ser218VSGQLIDsMANSFVGphosphorylation
up-regulates activity		8131746SIGNOR-235587
BRAFMAP2K1Ser218VSGQLIDsMANSFVGphosphorylation
up-regulates activity		8131746SIGNOR-235475
MAP3K21MAP2K1Ser218VSGQLIDsMANSFVGphosphorylation
up-regulates activity		23319808SIGNOR-260767
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
MAP3K8phosphorylation
up-regulates
→
MAP2K1
PSer218		phosphorylation
up-regulates
→		MAP2K115466476SIGNOR-129690
RAF1phosphorylation
up-regulates
→
MAP2K1
PSer218		phosphorylation
up-regulates
→		MAP2K110359597SIGNOR-235987
ARAFphosphorylation
up-regulates
→
MAP2K1
PSer218		phosphorylation
up-regulates
→		MAP2K18621729SIGNOR-236451
MAP3K1phosphorylation
up-regulates
→
MAP2K1
PSer218		phosphorylation
up-regulates
→		MAP2K18131746SIGNOR-235587
BRAFphosphorylation
up-regulates
→
MAP2K1
PSer218		phosphorylation
up-regulates
→		MAP2K18131746SIGNOR-235475
MAP3K21phosphorylation
up-regulates
→
MAP2K1
PSer218		phosphorylation
up-regulates
→		MAP2K123319808SIGNOR-260767
Regulator Mechanism/Effect Target SIGNOR-ID
MAP3K8phosphorylation
→
up-regulates 		MAP2K1SIGNOR-129690
RAF1phosphorylation
→
up-regulates activity 		MAP2K1SIGNOR-235987
ARAFphosphorylation
→
up-regulates 		MAP2K1SIGNOR-236451
MAP3K1phosphorylation
→
up-regulates activity 		MAP2K1SIGNOR-235587
BRAFphosphorylation
→
up-regulates activity 		MAP2K1SIGNOR-235475
MAP3K21phosphorylation
→
up-regulates activity 		MAP2K1SIGNOR-260767