| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| BRAF | MAP2K1 | Ser222 | LIDSMANsFVGTRSY | phosphorylation up-regulates activity | 8413257 | SIGNOR-39054 |
| MOS | MAP2K1 | Ser222 | LIDSMANsFVGTRSY | phosphorylation up-regulates activity | 7731726 | SIGNOR-260920 |
| MAP3K21 | MAP2K1 | Ser222 | LIDSMANsFVGTRSY | phosphorylation up-regulates activity | 23319808 | SIGNOR-260768 |
| MAP3K1 | MAP2K1 | Ser222 | LIDSMANsFVGTRSY | phosphorylation up-regulates activity | 8131746 | SIGNOR-235564 |
| ARAF | MAP2K1 | Ser222 | LIDSMANsFVGTRSY | phosphorylation up-regulates | 8621729 | SIGNOR-235944 |
| PDPK1 | MAP2K1 | Ser222 | LIDSMANsFVGTRSY | phosphorylation up-regulates activity | 15175348 | SIGNOR-236633 |
| RAF1 | MAP2K1 | Ser222 | LIDSMANsFVGTRSY | phosphorylation up-regulates activity | 10359597 | SIGNOR-235991 |
| MAP3K8 | MAP2K1 | Ser222 | LIDSMANsFVGTRSY | phosphorylation up-regulates | 8131746 | SIGNOR-36449 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| BRAF | phosphorylation up-regulates → | MAP2K1 PSer222 | phosphorylation up-regulates → | MAP2K1 | 8413257 | SIGNOR-39054 |
| MOS | phosphorylation up-regulates → | MAP2K1 PSer222 | phosphorylation up-regulates → | MAP2K1 | 7731726 | SIGNOR-260920 |
| MAP3K21 | phosphorylation up-regulates → | MAP2K1 PSer222 | phosphorylation up-regulates → | MAP2K1 | 23319808 | SIGNOR-260768 |
| MAP3K1 | phosphorylation up-regulates → | MAP2K1 PSer222 | phosphorylation up-regulates → | MAP2K1 | 8131746 | SIGNOR-235564 |
| ARAF | phosphorylation up-regulates → | MAP2K1 PSer222 | phosphorylation up-regulates → | MAP2K1 | 8621729 | SIGNOR-235944 |
| PDPK1 | phosphorylation up-regulates → | MAP2K1 PSer222 | phosphorylation up-regulates → | MAP2K1 | 15175348 | SIGNOR-236633 |
| RAF1 | phosphorylation up-regulates → | MAP2K1 PSer222 | phosphorylation up-regulates → | MAP2K1 | 10359597 | SIGNOR-235991 |
| MAP3K8 | phosphorylation up-regulates → | MAP2K1 PSer222 | phosphorylation up-regulates → | MAP2K1 | 8131746 | SIGNOR-36449 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| BRAF | phosphorylation → up-regulates activity | MAP2K1 | SIGNOR-39054 |
| MOS | phosphorylation → up-regulates activity | MAP2K1 | SIGNOR-260920 |
| MAP3K21 | phosphorylation → up-regulates activity | MAP2K1 | SIGNOR-260768 |
| MAP3K1 | phosphorylation → up-regulates activity | MAP2K1 | SIGNOR-235564 |
| ARAF | phosphorylation → up-regulates | MAP2K1 | SIGNOR-235944 |
| PDPK1 | phosphorylation → up-regulates activity | MAP2K1 | SIGNOR-236633 |
| RAF1 | phosphorylation → up-regulates activity | MAP2K1 | SIGNOR-235991 |
| MAP3K8 | phosphorylation → up-regulates | MAP2K1 | SIGNOR-36449 |
