Entity Details

Name TEK
ID Q02763
Role kinase
Enzymatic Domains
Ig-like C2-type 1 44-123
EGF-like 1 210-252
PROSITE-ProRule
EGF-like 2 254-299
PROSITE-ProRule
EGF-like 3 301-341
PROSITE-ProRule
Ig-like C2-type 2 350-440
Fibronectin type-III 1 447-541
PROSITE-ProRule
Fibronectin type-III 2 545-636
PROSITE-ProRule
Fibronectin type-III 3 641-735
PROSITE-ProRule
Protein kinase 824-1096
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
TEKTIE1–phosphorylation
up-regulates activity		15851516SIGNOR-279769
TEKSTAT1Tyr701DGPKGTGyIKTELISphosphorylation
up-regulates activity		18401423SIGNOR-279131
TEKTEKTyr897GACEHRGyLYLAIEYphosphorylation
down-regulates activity		11080633SIGNOR-246662
TEKTEKTyr1048GMTCAELyEKLPQGYphosphorylation
up-regulates activity		11513602SIGNOR-109786
TEKTEKTyr992LSRGQEVyVKKTMGRphosphorylation
up-regulates activity		11513602SIGNOR-109790
TEKTEKTyr1102MLEERKTyVNTTLYEphosphorylation
up-regulates activity		12082108SIGNOR-246657
TEKTEKTyr1102MLEERKTyVNTTLYEphosphorylation
up-regulates activity		20973951SIGNOR-259834
TEKTEKTyr1108TYVNTTLyEKFTYAGphosphorylation
up-regulates activity		20973951SIGNOR-259833
TEKGRB14–phosphorylation
up-regulates activity		20973951SIGNOR-279300
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
TEKphosphorylation
up-regulates
→
STAT1
PTyr701		phosphorylation
up-regulates
→		STAT118401423SIGNOR-279131
TEKphosphorylation
up-regulates
→
TEK
PTyr897		phosphorylation
down-regulates
⊣		TEK11080633SIGNOR-246662
TEKphosphorylation
up-regulates
→
TEK
PTyr1048		phosphorylation
up-regulates
→		TEK11513602SIGNOR-109786
TEKphosphorylation
up-regulates
→
TEK
PTyr992		phosphorylation
up-regulates
→		TEK11513602SIGNOR-109790
TEKphosphorylation
up-regulates
→
TEK
PTyr1102		phosphorylation
up-regulates
→		TEK12082108SIGNOR-246657
TEKphosphorylation
up-regulates
→
TEK
PTyr1102		phosphorylation
up-regulates
→		TEK20973951SIGNOR-259834
TEKphosphorylation
up-regulates
→
TEK
PTyr1108		phosphorylation
up-regulates
→		TEK20973951SIGNOR-259833
Regulator Mechanism/Effect Target SIGNOR-ID
TEKphosphorylation
→
up-regulates activity 		TIE1SIGNOR-279769
TEKphosphorylation
→
up-regulates activity 		STAT1SIGNOR-279131
TEKphosphorylation
→
down-regulates activity 		TEKSIGNOR-246662
TEKphosphorylation
→
up-regulates activity 		TEKSIGNOR-109786
TEKphosphorylation
→
up-regulates activity 		TEKSIGNOR-109790
TEKphosphorylation
→
up-regulates activity 		TEKSIGNOR-246657
TEKphosphorylation
→
up-regulates activity 		TEKSIGNOR-259834
TEKphosphorylation
→
up-regulates activity 		TEKSIGNOR-259833
TEKphosphorylation
→
up-regulates activity 		GRB14SIGNOR-279300