| Name | TEK |
| ID | Q02763 |
| Role | substrate |
| Enzymatic Domains |
Ig-like C2-type 1 44-123
EGF-like 1 210-252 PROSITE-ProRule
EGF-like 2 254-299 PROSITE-ProRule
EGF-like 3 301-341 PROSITE-ProRule
Ig-like C2-type 2 350-440
Fibronectin type-III 1 447-541 PROSITE-ProRule
Fibronectin type-III 2 545-636 PROSITE-ProRule
Fibronectin type-III 3 641-735 PROSITE-ProRule
Protein kinase 824-1096 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| TEK | TEK | Tyr1048 | GMTCAELyEKLPQGY | phosphorylation up-regulates activity | 11513602 | SIGNOR-109786 |
| TEK | TEK | Tyr992 | LSRGQEVyVKKTMGR | phosphorylation up-regulates activity | 11513602 | SIGNOR-109790 |
| TEK | TEK | Tyr897 | GACEHRGyLYLAIEY | phosphorylation down-regulates activity | 11080633 | SIGNOR-246662 |
| TEK | TEK | Tyr1108 | TYVNTTLyEKFTYAG | phosphorylation up-regulates activity | 20973951 | SIGNOR-259833 |
| TEK | TEK | Tyr1102 | MLEERKTyVNTTLYE | phosphorylation up-regulates activity | 20973951 | SIGNOR-259834 |
| PTPRB | TEK | – | dephosphorylation down-regulates activity | 34417472 | SIGNOR-277059 | |
| TEK | TEK | Tyr1102 | MLEERKTyVNTTLYE | phosphorylation up-regulates activity | 12082108 | SIGNOR-246657 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| TEK | phosphorylation up-regulates → | TEK PTyr1048 | phosphorylation up-regulates → | TEK | 11513602 | SIGNOR-109786 |
| TEK | phosphorylation up-regulates → | TEK PTyr992 | phosphorylation up-regulates → | TEK | 11513602 | SIGNOR-109790 |
| TEK | phosphorylation up-regulates → | TEK PTyr897 | phosphorylation down-regulates ⊣ | TEK | 11080633 | SIGNOR-246662 |
| TEK | phosphorylation up-regulates → | TEK PTyr1108 | phosphorylation up-regulates → | TEK | 20973951 | SIGNOR-259833 |
| TEK | phosphorylation up-regulates → | TEK PTyr1102 | phosphorylation up-regulates → | TEK | 20973951 | SIGNOR-259834 |
| TEK | phosphorylation up-regulates → | TEK PTyr1102 | phosphorylation up-regulates → | TEK | 12082108 | SIGNOR-246657 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| TEK | phosphorylation → up-regulates activity | TEK | SIGNOR-109786 |
| TEK | phosphorylation → up-regulates activity | TEK | SIGNOR-109790 |
| TEK | phosphorylation → down-regulates activity | TEK | SIGNOR-246662 |
| TEK | phosphorylation → up-regulates activity | TEK | SIGNOR-259833 |
| TEK | phosphorylation → up-regulates activity | TEK | SIGNOR-259834 |
| PTPRB | dephosphorylation → down-regulates activity | TEK | SIGNOR-277059 |
| TEK | phosphorylation → up-regulates activity | TEK | SIGNOR-246657 |