Entity Details

Name TOP2B
ID Q02880
Role substrate
Enzymatic Domains
Toprim 476-593
PROSITE-ProRule
Topo IIA-type catalytic 736-1189
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
ATMTOP2BSer1135HDDSSSDsGTPSGPDphosphorylation
down-regulates quantity by destabilization		32015321SIGNOR-277510
CSNK1DTOP2BSer1132QNQHDDSsSDSGTPSphosphorylation
down-regulates quantity by destabilization		32015321SIGNOR-277509
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
ATMphosphorylation
up-regulates
→
TOP2B
PSer1135		phosphorylation
down-regulates
⊣		TOP2B32015321SIGNOR-277510
CSNK1Dphosphorylation
up-regulates
→
TOP2B
PSer1132		phosphorylation
down-regulates
⊣		TOP2B32015321SIGNOR-277509
Regulator Mechanism/Effect Target SIGNOR-ID
ATMphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		TOP2BSIGNOR-277510
CSNK1Dphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		TOP2BSIGNOR-277509