| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CyclinB/CDK1 | AKAP12 | Thr767 | ESFKRLVtPRKKSKS | phosphorylation up-regulates activity | 23063527 | SIGNOR-271840 |
| ATR | AKAP12 | Ser732 | TDGILAGsQEHDPGQ | phosphorylation up-regulates activity | 27683220 | SIGNOR-278292 |
| PRKACA | AKAP12 | Ser772 | LVTPRKKsKSKLEEK | phosphorylation up-regulates activity | 14657015 | SIGNOR-271842 |
| PRKACA | AKAP12 | Ser627 | KKRVRRPsESDKEDE | phosphorylation up-regulates activity | 14657015 | SIGNOR-271841 |
| CDK1 | AKAP12 | Thr767 | ESFKRLVtPRKKSKS | phosphorylation up-regulates activity | 23063527 | SIGNOR-271839 |
| PRKACA | AKAP12 | Ser696 | KKRARRGsSSDEEGG | phosphorylation up-regulates activity | 14657015 | SIGNOR-271843 |
| PRKACA | AKAP12 | Ser698 | RARRGSSsDEEGGPK | phosphorylation up-regulates activity | 14657015 | SIGNOR-271844 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CyclinB/CDK1 | phosphorylation up-regulates → | AKAP12 PThr767 | phosphorylation up-regulates → | AKAP12 | 23063527 | SIGNOR-271840 |
| ATR | phosphorylation up-regulates → | AKAP12 PSer732 | phosphorylation up-regulates → | AKAP12 | 27683220 | SIGNOR-278292 |
| PRKACA | phosphorylation up-regulates → | AKAP12 PSer772 | phosphorylation up-regulates → | AKAP12 | 14657015 | SIGNOR-271842 |
| PRKACA | phosphorylation up-regulates → | AKAP12 PSer627 | phosphorylation up-regulates → | AKAP12 | 14657015 | SIGNOR-271841 |
| CDK1 | phosphorylation up-regulates → | AKAP12 PThr767 | phosphorylation up-regulates → | AKAP12 | 23063527 | SIGNOR-271839 |
| PRKACA | phosphorylation up-regulates → | AKAP12 PSer696 | phosphorylation up-regulates → | AKAP12 | 14657015 | SIGNOR-271843 |
| PRKACA | phosphorylation up-regulates → | AKAP12 PSer698 | phosphorylation up-regulates → | AKAP12 | 14657015 | SIGNOR-271844 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CyclinB/CDK1 | phosphorylation → up-regulates activity | AKAP12 | SIGNOR-271840 |
| ATR | phosphorylation → up-regulates activity | AKAP12 | SIGNOR-278292 |
| PRKACA | phosphorylation → up-regulates activity | AKAP12 | SIGNOR-271842 |
| PRKACA | phosphorylation → up-regulates activity | AKAP12 | SIGNOR-271841 |
| CDK1 | phosphorylation → up-regulates activity | AKAP12 | SIGNOR-271839 |
| PRKACA | phosphorylation → up-regulates activity | AKAP12 | SIGNOR-271843 |
| PRKACA | phosphorylation → up-regulates activity | AKAP12 | SIGNOR-271844 |
