| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK1 | CREM | Ser277 | ASPGSLHsPQQLAEE | phosphorylation down-regulates quantity by destabilization | 11466319 | SIGNOR-275979 |
| MAPK3 | CREM | Ser277 | ASPGSLHsPQQLAEE | phosphorylation down-regulates quantity by destabilization | 11466319 | SIGNOR-275978 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK1 | phosphorylation up-regulates → | CREM PSer277 | phosphorylation down-regulates ⊣ | CREM | 11466319 | SIGNOR-275979 |
| MAPK3 | phosphorylation up-regulates → | CREM PSer277 | phosphorylation down-regulates ⊣ | CREM | 11466319 | SIGNOR-275978 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDK1 | phosphorylation![]() down-regulates quantity by destabilization | CREM | SIGNOR-275979 |
| MAPK3 | phosphorylation![]() down-regulates quantity by destabilization | CREM | SIGNOR-275978 |