| Name | NOTCH2 |
| ID | Q04721 |
| Role | substrate |
| Enzymatic Domains |
EGF-like 1 26-63 PROSITE-ProRule
EGF-like 2 64-102 PROSITE-ProRule
EGF-like 3 105-143 PROSITE-ProRule
EGF-like 4 144-180 PROSITE-ProRule
EGF-like 5; calcium-binding 182-219 PROSITE-ProRule
EGF-like 6 221-258 PROSITE-ProRule
EGF-like 7; calcium-binding 260-296 PROSITE-ProRule
EGF-like 8; calcium-binding 298-336 PROSITE-ProRule
EGF-like 9; calcium-binding 338-374 PROSITE-ProRule
EGF-like 10 375-413 PROSITE-ProRule
EGF-like 11; calcium-binding 415-454 PROSITE-ProRule
EGF-like 12; calcium-binding 456-492 PROSITE-ProRule
EGF-like 13; calcium-binding 494-530 PROSITE-ProRule
EGF-like 14; calcium-binding 532-568 PROSITE-ProRule
EGF-like 15; calcium-binding 570-605 PROSITE-ProRule
EGF-like 16; calcium-binding 607-643 PROSITE-ProRule
EGF-like 17; calcium-binding 645-680 PROSITE-ProRule
EGF-like 18; calcium-binding 682-718 PROSITE-ProRule
EGF-like 19 720-755 PROSITE-ProRule
EGF-like 20; calcium-binding 757-793 PROSITE-ProRule
EGF-like 21; calcium-binding 795-831 PROSITE-ProRule
EGF-like 22 833-871 PROSITE-ProRule
EGF-like 23; calcium-binding 873-909 PROSITE-ProRule
EGF-like 24; calcium-binding 911-947 PROSITE-ProRule
EGF-like 25; calcium-binding 949-985 PROSITE-ProRule
EGF-like 26; calcium-binding 987-1023 PROSITE-ProRule
EGF-like 27; calcium-binding 1025-1061 PROSITE-ProRule
EGF-like 28 1063-1099 PROSITE-ProRule
EGF-like 29 1101-1147 Notice: Undefined index: source in /home/prisca/signor/PhosphoSIGNOR/results/getDomains.php on line 17 Notice: Undefined index: source in /home/prisca/signor/PhosphoSIGNOR/results/getDomains.php on line 20 Notice: Undefined index: source in /home/prisca/signor/PhosphoSIGNOR/results/getDomains.php on line 23 Notice: Undefined index: source in /home/prisca/signor/PhosphoSIGNOR/results/getDomains.php on line 26
EGF-like 30; calcium-binding 1149-1185 PROSITE-ProRule
EGF-like 31; calcium-binding 1187-1223 PROSITE-ProRule
EGF-like 32; calcium-binding 1225-1262 PROSITE-ProRule
EGF-like 33 1264-1302 PROSITE-ProRule
EGF-like 34 1304-1343 PROSITE-ProRule
EGF-like 35 1374-1412 PROSITE-ProRule |
View in  |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3B | NOTCH2 | Ser2070 | DEYNVTPsPPGTVLT | phosphorylation down-regulates activity | 12794074 | SIGNOR-251254 |
| GSK3B | NOTCH2 | Thr2068 | LLDEYNVtPSPPGTV | phosphorylation down-regulates activity | 12794074 | SIGNOR-101570 |
| GSK3B | NOTCH2 | Ser2093 | GPNRSFLsLKHTPMG | phosphorylation down-regulates activity | 12794074 | SIGNOR-251253 |
| GSK3B | NOTCH2 | Thr2074 | VTPSPPGtVLTSALS | phosphorylation down-regulates activity | 12794074 | SIGNOR-101574 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3B | phosphorylation up-regulates → | NOTCH2 PSer2070 | phosphorylation down-regulates ⊣ | NOTCH2 | 12794074 | SIGNOR-251254 |
| GSK3B | phosphorylation up-regulates → | NOTCH2 PThr2068 | phosphorylation down-regulates ⊣ | NOTCH2 | 12794074 | SIGNOR-101570 |
| GSK3B | phosphorylation up-regulates → | NOTCH2 PSer2093 | phosphorylation down-regulates ⊣ | NOTCH2 | 12794074 | SIGNOR-251253 |
| GSK3B | phosphorylation up-regulates → | NOTCH2 PThr2074 | phosphorylation down-regulates ⊣ | NOTCH2 | 12794074 | SIGNOR-101574 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| GSK3B | phosphorylation → down-regulates activity | NOTCH2 | SIGNOR-251254 |
| GSK3B | phosphorylation → down-regulates activity | NOTCH2 | SIGNOR-101570 |
| GSK3B | phosphorylation → down-regulates activity | NOTCH2 | SIGNOR-251253 |
| GSK3B | phosphorylation → down-regulates activity | NOTCH2 | SIGNOR-101574 |