| Name | PRKCQ |
| ID | Q04759 |
| Role | kinase |
| Enzymatic Domains |
C2 1-107 PROSITE-ProRule
Protein kinase 380-634 PROSITE-ProRule
AGC-kinase C-terminal 635-706 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCQ | WIPF1 | Ser488 | RNESRSGsNRRERGA | phosphorylation up-regulates activity | 12504004 | SIGNOR-249181 |
| PRKCQ | KDM1A | Ser111 | TPEGRRTsRRKRAKV | phosphorylation down-regulates activity | 29311580 | SIGNOR-279104 |
| PRKCQ | FOSL1 | Thr217 | LEPEALHtPTLMTTP | phosphorylation up-regulates activity | 27816489 | SIGNOR-260878 |
| PRKCQ | FOSL1 | Thr227 | LEPEALHtPTLMTTP | phosphorylation up-regulates activity | 27816489 | SIGNOR-260879 |
| PRKCQ | CBL | – | phosphorylation up-regulates activity | 26284074 | SIGNOR-274144 | |
| PRKCQ | MSN | Thr558 | LGRDKYKtLRQIRQG | phosphorylation unknown | 9856983 | SIGNOR-249013 |
| PRKCQ | PTPN6 | Ser591 | DKEKSKGsLKRK | phosphorylation down-regulates activity | 35258455 | SIGNOR-277590 |
| PRKCQ | NOS3 | Thr495 | TGITRKKtFKEVANA | phosphorylation down-regulates activity | 24379783 | SIGNOR-251636 |
| PRKCQ | ICAM3 | Ser518 | REHQRSGsYHVREES | phosphorylation up-regulates activity | 9268366 | SIGNOR-248979 |
| PRKCQ | PTPN7 | Ser246 | QYQEERRsVKHILFS | phosphorylation up-regulates activity | 16479000 | SIGNOR-276045 |
| PRKCQ | IRS1 | Ser1101 | GCRRRHSsETFSSTP | phosphorylation down-regulates activity | 15364919 | SIGNOR-260906 |
| PRKCQ | GRM5 | Ser840 | VRSAFTTsTVVRMHV | phosphorylation up-regulates activity | 15894802 | SIGNOR-249283 |
| PRKCQ | GRM5 | Thr841 | RSAFTTStVVRMHVG | phosphorylation up-regulates activity | 15894802 | SIGNOR-249290 |
| PRKCQ | HSF1 | – | phosphorylation up-regulates | 23352416 | SIGNOR-200576 | |
| PRKCQ | PRKCQ | Thr219 | SAINSREtMFHKERF | phosphorylation up-regulates activity | 16252004 | SIGNOR-249298 |
| PRKCQ | ARHGEF6 | Ser225 | KSSERPLsPKAVKGF | phosphorylation up-regulates activity | 25694429 | SIGNOR-272169 |
| PRKCQ | ARHGEF6 | Ser488 | LSASPRMsGFIYQGK | phosphorylation up-regulates activity | 25694429 | SIGNOR-272168 |
| PRKCQ | HABP4 | Thr354 | RKPANDItSQLEINF | phosphorylation down-regulates activity | 14699138 | SIGNOR-249250 |
| PRKCQ | HABP4 | Thr375 | GRGARGGtRGGRGRI | phosphorylation down-regulates activity | 14699138 | SIGNOR-249256 |
| PRKCQ | RASGRP3 | Thr133 | YDWMRRVtQRKKVSK | phosphorylation up-regulates | 15545601 | SIGNOR-130490 |
| PRKCQ | CARD11 | Ser893 | SPRLSRAsFLFGQLL | phosphorylation down-regulates activity | 35230873 | SIGNOR-276298 |
| PRKCQ | CARD11 | Ser644 | NLMFRKFsLERPFRP | phosphorylation up-regulates activity | 21157432 | SIGNOR-249193 |
| PRKCQ | STK39 | Ser309 | MMKKYGKsFRKLLSL | phosphorylation up-regulates activity | 14988727 | SIGNOR-276006 |
| PRKCQ | STK39 | Ser323 | LCLQKDPsKRPTAAE | phosphorylation up-regulates activity | 14988727 | SIGNOR-276007 |
| PRKCQ | TBK1 | Ser716 | HILERFGsLTMDGGL | phosphorylation up-regulates activity | 31792381 | SIGNOR-272472 |
| PRKCQ | RAPGEF2 | Ser960 | KKRVRRSsFLNAKKL | phosphorylation up-regulates | 18796635 | SIGNOR-181186 |
| PRKCQ | MGluR | – | phosphorylation up-regulates activity | 15894802 | SIGNOR-270273 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCQ | phosphorylation up-regulates → | WIPF1 PSer488 | phosphorylation up-regulates → | WIPF1 | 12504004 | SIGNOR-249181 |
| PRKCQ | phosphorylation up-regulates → | KDM1A PSer111 | phosphorylation down-regulates ⊣ | KDM1A | 29311580 | SIGNOR-279104 |
| PRKCQ | phosphorylation up-regulates → | FOSL1 PThr217 | phosphorylation up-regulates → | FOSL1 | 27816489 | SIGNOR-260878 |
| PRKCQ | phosphorylation up-regulates → | FOSL1 PThr227 | phosphorylation up-regulates → | FOSL1 | 27816489 | SIGNOR-260879 |
| PRKCQ | phosphorylation up-regulates → | MSN PThr558 | phosphorylation down-regulates ⊣ | MSN | 9856983 | SIGNOR-249013 |
| PRKCQ | phosphorylation up-regulates → | PTPN6 PSer591 | phosphorylation down-regulates ⊣ | PTPN6 | 35258455 | SIGNOR-277590 |
| PRKCQ | phosphorylation up-regulates → | NOS3 PThr495 | phosphorylation down-regulates ⊣ | NOS3 | 24379783 | SIGNOR-251636 |
| PRKCQ | phosphorylation up-regulates → | ICAM3 PSer518 | phosphorylation up-regulates → | ICAM3 | 9268366 | SIGNOR-248979 |
| PRKCQ | phosphorylation up-regulates → | PTPN7 PSer246 | phosphorylation up-regulates → | PTPN7 | 16479000 | SIGNOR-276045 |
| PRKCQ | phosphorylation up-regulates → | IRS1 PSer1101 | phosphorylation down-regulates ⊣ | IRS1 | 15364919 | SIGNOR-260906 |
| PRKCQ | phosphorylation up-regulates → | GRM5 PSer840 | phosphorylation up-regulates → | GRM5 | 15894802 | SIGNOR-249283 |
| PRKCQ | phosphorylation up-regulates → | GRM5 PThr841 | phosphorylation up-regulates → | GRM5 | 15894802 | SIGNOR-249290 |
| PRKCQ | phosphorylation up-regulates → | PRKCQ PThr219 | phosphorylation up-regulates → | PRKCQ | 16252004 | SIGNOR-249298 |
| PRKCQ | phosphorylation up-regulates → | ARHGEF6 PSer225 | phosphorylation up-regulates → | ARHGEF6 | 25694429 | SIGNOR-272169 |
| PRKCQ | phosphorylation up-regulates → | ARHGEF6 PSer488 | phosphorylation up-regulates → | ARHGEF6 | 25694429 | SIGNOR-272168 |
| PRKCQ | phosphorylation up-regulates → | HABP4 PThr354 | phosphorylation down-regulates ⊣ | HABP4 | 14699138 | SIGNOR-249250 |
| PRKCQ | phosphorylation up-regulates → | HABP4 PThr375 | phosphorylation down-regulates ⊣ | HABP4 | 14699138 | SIGNOR-249256 |
| PRKCQ | phosphorylation up-regulates → | RASGRP3 PThr133 | phosphorylation up-regulates → | RASGRP3 | 15545601 | SIGNOR-130490 |
| PRKCQ | phosphorylation up-regulates → | CARD11 PSer893 | phosphorylation down-regulates ⊣ | CARD11 | 35230873 | SIGNOR-276298 |
| PRKCQ | phosphorylation up-regulates → | CARD11 PSer644 | phosphorylation up-regulates → | CARD11 | 21157432 | SIGNOR-249193 |
| PRKCQ | phosphorylation up-regulates → | STK39 PSer309 | phosphorylation up-regulates → | STK39 | 14988727 | SIGNOR-276006 |
| PRKCQ | phosphorylation up-regulates → | STK39 PSer323 | phosphorylation up-regulates → | STK39 | 14988727 | SIGNOR-276007 |
| PRKCQ | phosphorylation up-regulates → | TBK1 PSer716 | phosphorylation up-regulates → | TBK1 | 31792381 | SIGNOR-272472 |
| PRKCQ | phosphorylation up-regulates → | RAPGEF2 PSer960 | phosphorylation up-regulates → | RAPGEF2 | 18796635 | SIGNOR-181186 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKCQ | phosphorylation → up-regulates activity | WIPF1 | SIGNOR-249181 |
| PRKCQ | phosphorylation → down-regulates activity | KDM1A | SIGNOR-279104 |
| PRKCQ | phosphorylation → up-regulates activity | FOSL1 | SIGNOR-260878 |
| PRKCQ | phosphorylation → up-regulates activity | FOSL1 | SIGNOR-260879 |
| PRKCQ | phosphorylation → up-regulates activity | CBL | SIGNOR-274144 |
| PRKCQ | phosphorylation → unknown | MSN | SIGNOR-249013 |
| PRKCQ | phosphorylation → down-regulates activity | PTPN6 | SIGNOR-277590 |
| PRKCQ | phosphorylation → down-regulates activity | NOS3 | SIGNOR-251636 |
| PRKCQ | phosphorylation → up-regulates activity | ICAM3 | SIGNOR-248979 |
| PRKCQ | phosphorylation → up-regulates activity | PTPN7 | SIGNOR-276045 |
| PRKCQ | phosphorylation → down-regulates activity | IRS1 | SIGNOR-260906 |
| PRKCQ | phosphorylation → up-regulates activity | GRM5 | SIGNOR-249283 |
| PRKCQ | phosphorylation → up-regulates activity | GRM5 | SIGNOR-249290 |
| PRKCQ | phosphorylation → up-regulates | HSF1 | SIGNOR-200576 |
| PRKCQ | phosphorylation → up-regulates activity | PRKCQ | SIGNOR-249298 |
| PRKCQ | phosphorylation → up-regulates activity | ARHGEF6 | SIGNOR-272169 |
| PRKCQ | phosphorylation → up-regulates activity | ARHGEF6 | SIGNOR-272168 |
| PRKCQ | phosphorylation → down-regulates activity | HABP4 | SIGNOR-249250 |
| PRKCQ | phosphorylation → down-regulates activity | HABP4 | SIGNOR-249256 |
| PRKCQ | phosphorylation → up-regulates | RASGRP3 | SIGNOR-130490 |
| PRKCQ | phosphorylation → down-regulates activity | CARD11 | SIGNOR-276298 |
| PRKCQ | phosphorylation → up-regulates activity | CARD11 | SIGNOR-249193 |
| PRKCQ | phosphorylation → up-regulates activity | STK39 | SIGNOR-276006 |
| PRKCQ | phosphorylation → up-regulates activity | STK39 | SIGNOR-276007 |
| PRKCQ | phosphorylation → up-regulates activity | TBK1 | SIGNOR-272472 |
| PRKCQ | phosphorylation → up-regulates | RAPGEF2 | SIGNOR-181186 |
| PRKCQ | phosphorylation → up-regulates activity | MGluR | SIGNOR-270273 |