Entity Details

Name UBE3A
ID Q05086
Role substrate
Enzymatic Domains
HECT 776-875
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
ABL1UBE3ATyr659GDSHPVLyQSLKDLLphosphorylation
down-regulates activity		23581475SIGNOR-260930
PRKACAUBE3AThr508MYSERRItVLYSLVQphosphorylation
down-regulates activity		26255772SIGNOR-236899
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
ABL1phosphorylation
up-regulates
→
UBE3A
PTyr659		phosphorylation
down-regulates
⊣		UBE3A23581475SIGNOR-260930
PRKACAphosphorylation
up-regulates
→
UBE3A
PThr508		phosphorylation
down-regulates
⊣		UBE3A26255772SIGNOR-236899
Regulator Mechanism/Effect Target SIGNOR-ID
ABL1phosphorylation
→
down-regulates activity 		UBE3ASIGNOR-260930
PRKACAphosphorylation
→
down-regulates activity 		UBE3ASIGNOR-236899