| Name | DNM1 |
| ID | Q05193 |
| Role | substrate |
| Enzymatic Domains |
Dynamin-type G 28-294 PROSITE-ProRule
PH 519-625 PROSITE-ProRule
GED 659-750 PROSITE-ProRule |
View in  |
|
| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| DYRK1A | DNM1 | Ser857 | ASPSRPEsPRPPFDL | phosphorylation down-regulates | 15287745 | SIGNOR-127444 |
| CDK5 | DNM1 | Ser774 | SVPAGRRsPTSSPTP | phosphorylation up-regulates activity | 12855954 | SIGNOR-250661 |
| SRC | DNM1 | Tyr231 | LLPLRRGyIGVVNRS | phosphorylation up-regulates activity | 9880482 | SIGNOR-247124 |
| PRKCA | DNM1 | Ser795 | VPPARPGsRGPAPGP | phosphorylation unknown | 10766777 | SIGNOR-249039 |
| SRC | DNM1 | Tyr597 | NTEQRNVyKDYRQLE | phosphorylation up-regulates activity | 12011079 | SIGNOR-247129 |
| DYRK1A | DNM1 | Ser795 | VPPARPGsRGPAPGP | phosphorylation down-regulates | 15287745 | SIGNOR-127440 |
| CDK5 | DNM1 | Ser778 | GRRSPTSsPTPQRRA | phosphorylation up-regulates activity | 12855954 | SIGNOR-250662 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| DYRK1A | phosphorylation up-regulates → | DNM1 PSer857 | phosphorylation down-regulates ⊣ | DNM1 | 15287745 | SIGNOR-127444 |
| CDK5 | phosphorylation up-regulates → | DNM1 PSer774 | phosphorylation up-regulates → | DNM1 | 12855954 | SIGNOR-250661 |
| SRC | phosphorylation up-regulates → | DNM1 PTyr231 | phosphorylation up-regulates → | DNM1 | 9880482 | SIGNOR-247124 |
| PRKCA | phosphorylation up-regulates → | DNM1 PSer795 | phosphorylation down-regulates ⊣ | DNM1 | 10766777 | SIGNOR-249039 |
| SRC | phosphorylation up-regulates → | DNM1 PTyr597 | phosphorylation up-regulates → | DNM1 | 12011079 | SIGNOR-247129 |
| DYRK1A | phosphorylation up-regulates → | DNM1 PSer795 | phosphorylation down-regulates ⊣ | DNM1 | 15287745 | SIGNOR-127440 |
| CDK5 | phosphorylation up-regulates → | DNM1 PSer778 | phosphorylation up-regulates → | DNM1 | 12855954 | SIGNOR-250662 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| DYRK1A | phosphorylation down-regulates | DNM1 | SIGNOR-127444 |
| CDK5 | phosphorylation → up-regulates activity | DNM1 | SIGNOR-250661 |
| SRC | phosphorylation → up-regulates activity | DNM1 | SIGNOR-247124 |
| PRKCA | phosphorylation → unknown | DNM1 | SIGNOR-249039 |
| SRC | phosphorylation → up-regulates activity | DNM1 | SIGNOR-247129 |
| DYRK1A | phosphorylation down-regulates | DNM1 | SIGNOR-127440 |
| CDK5 | phosphorylation → up-regulates activity | DNM1 | SIGNOR-250662 |