| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| RPS6K | MXD1 | Ser145 | IERIRMDsIGSTVSS | phosphorylation down-regulates | 18451027 | SIGNOR-252811 |
| RPS6KB2 | MXD1 | Ser145 | IERIRMDsIGSTVSS | phosphorylation down-regulates | 18451027 | SIGNOR-178594 |
| RPS6KB1 | MXD1 | Ser145 | IERIRMDsIGSTVSS | phosphorylation down-regulates | 18451027 | SIGNOR-178590 |
| RPS6KA1 | MXD1 | Ser145 | IERIRMDsIGSTVSS | phosphorylation down-regulates | 18451027 | SIGNOR-178586 |
| AKT | MXD1 | Ser145 | IERIRMDsIGSTVSS | phosphorylation down-regulates | 19526459 | SIGNOR-186130 |
| AKT1 | MXD1 | Ser145 | IERIRMDsIGSTVSS | phosphorylation down-regulates | 19526459 | SIGNOR-252525 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| RPS6K | phosphorylation up-regulates → | MXD1 PSer145 | phosphorylation down-regulates ⊣ | MXD1 | 18451027 | SIGNOR-252811 |
| RPS6KB2 | phosphorylation up-regulates → | MXD1 PSer145 | phosphorylation down-regulates ⊣ | MXD1 | 18451027 | SIGNOR-178594 |
| RPS6KB1 | phosphorylation up-regulates → | MXD1 PSer145 | phosphorylation down-regulates ⊣ | MXD1 | 18451027 | SIGNOR-178590 |
| RPS6KA1 | phosphorylation up-regulates → | MXD1 PSer145 | phosphorylation down-regulates ⊣ | MXD1 | 18451027 | SIGNOR-178586 |
| AKT | phosphorylation up-regulates → | MXD1 PSer145 | phosphorylation down-regulates ⊣ | MXD1 | 19526459 | SIGNOR-186130 |
| AKT1 | phosphorylation up-regulates → | MXD1 PSer145 | phosphorylation down-regulates ⊣ | MXD1 | 19526459 | SIGNOR-252525 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| RPS6K | phosphorylation down-regulates | MXD1 | SIGNOR-252811 |
| RPS6KB2 | phosphorylation down-regulates | MXD1 | SIGNOR-178594 |
| RPS6KB1 | phosphorylation down-regulates | MXD1 | SIGNOR-178590 |
| RPS6KA1 | phosphorylation down-regulates | MXD1 | SIGNOR-178586 |
| AKT | phosphorylation down-regulates | MXD1 | SIGNOR-186130 |
| AKT1 | phosphorylation down-regulates | MXD1 | SIGNOR-252525 |
