| Name | PTK2 |
| ID | Q05397 |
| Role | kinase |
| Enzymatic Domains |
FERM 35-355 PROSITE-ProRule
Protein kinase 422-680 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTK2 | ARHGAP42 | Tyr376 | MDGKEPIyTLPAIIS | phosphorylation up-regulates activity | 32331391 | SIGNOR-280097 |
| PTK2 | WASL | – | phosphorylation up-regulates activity | 24290759 | SIGNOR-278977 | |
| PTK2 | PLD2 | – | phosphorylation up-regulates activity | 32843133 | SIGNOR-279480 | |
| PTK2 | ACTN4 | Tyr31 | GGGSMGDyMAQEDDW | phosphorylation down-regulates | 23454549 | SIGNOR-192195 |
| PTK2 | ACTN4 | Tyr4 | yHAANQSY | phosphorylation down-regulates | 23454549 | SIGNOR-192199 |
| PTK2 | ACTN4 | Tyr265 | MTYVSSFyHAFSGAQ | phosphorylation up-regulates | 23454549 | SIGNOR-192191 |
| PTK2 | TRIO | Tyr2796 | KDNFDSFySEVAELG | phosphorylation up-regulates activity | 12551902 | SIGNOR-249188 |
| PTK2 | RET | Tyr905 | DVYEEDSyVKRSQGR | phosphorylation up-regulates | 21454698 | SIGNOR-173009 |
| PTK2 | IGF1R | – | phosphorylation up-regulates quantity | 19545541 | SIGNOR-279565 | |
| PTK2 | ACTN1 | Tyr12 | DSQQTNDyMQPEEDW | phosphorylation down-regulates | 23454549 | SIGNOR-192126 |
| PTK2 | ACTN1 | Tyr12 | DSQQTNDyMQPEEDW | phosphorylation down-regulates activity | 11369769 | SIGNOR-108329 |
| PTK2 | SRC | Tyr419 | RLIEDNEyTARQGAK | phosphorylation up-regulates activity | 17828307 | SIGNOR-278452 |
| PTK2 | ATP2B4 | Tyr1176 | LDGEVTPyANTNNNA | phosphorylation up-regulates activity | 12540962 | SIGNOR-263194 |
| PTK2 | MYL9 | – | phosphorylation up-regulates activity | 32452639 | SIGNOR-280098 | |
| PTK2 | SHC1 | Tyr427 | ELFDDPSyVNVQNLD | phosphorylation up-regulates activity | 9566877 | SIGNOR-259854 |
| PTK2 | CTNNB1 | Tyr142 | AVVNLINyQDDAELA | phosphorylation unknown | 22264731 | SIGNOR-261946 |
| PTK2 | YAP1 | – | phosphorylation up-regulates activity | 33498611 | SIGNOR-280099 | |
| PTK2 | PXN | Tyr118 | VGEEEHVySFPNKQK | phosphorylation up-regulates activity | 15688067 | SIGNOR-28243 |
| PTK2 | PXN | Tyr31 | FLSEETPySYPTGNH | phosphorylation up-regulates activity | 15688067 | SIGNOR-28247 |
| PTK2 | GSK3B | – | phosphorylation up-regulates activity | 25472995 | SIGNOR-278986 | |
| PTK2 | BCAR1 | Tyr664 | EGGWMEDyDYVHLQG | phosphorylation unknown | 11604500 | SIGNOR-249111 |
| PTK2 | BCAR1 | Tyr666 | GWMEDYDyVHLQGKE | phosphorylation unknown | 11604500 | SIGNOR-249112 |
| PTK2 | RAC1 | – | phosphorylation up-regulates activity | 22163037 | SIGNOR-279652 | |
| PTK2 | PTK2 | Tyr397 | SVSETDDyAEIIDEE | phosphorylation up-regulates | 10816598 | SIGNOR-77434 |
| PTK2 | PTK2 | Tyr407 | IIDEEDTyTMPSTRD | phosphorylation up-regulates | 15694384 | SIGNOR-133837 |
| PTK2 | PTK2 | Tyr576 | RYMEDSTyYKASKGK | phosphorylation up-regulates | 15694384 | SIGNOR-133841 |
| PTK2 | PTK2 | Tyr577 | YMEDSTYyKASKGKL | phosphorylation up-regulates | 15694384 | SIGNOR-133845 |
| PTK2 | PTK2 | Tyr861 | PIGNQHIyQPVGKPD | phosphorylation up-regulates | 15694384 | SIGNOR-133849 |
| PTK2 | PTK2 | Tyr397 | SVSETDDyAEIIDEE | phosphorylation up-regulates | 17828307 | SIGNOR-157763 |
| PTK2 | PTK2 | Tyr576 | RYMEDSTyYKASKGK | phosphorylation up-regulates | 7529876 | SIGNOR-27875 |
| PTK2 | PTK2 | Tyr577 | YMEDSTYyKASKGKL | phosphorylation up-regulates | 7529876 | SIGNOR-27879 |
| PTK2 | CTTN | Tyr421 | RLPSSPVyEDAASFK | phosphorylation down-regulates activity | 22952866 | SIGNOR-278284 |
| PTK2 | CTTN | Tyr470 | AYATEAVyESAEAPG | phosphorylation down-regulates activity | 22952866 | SIGNOR-278283 |
| PTK2 | CTTN | Tyr486 | YPAEDSTyDEYENDL | phosphorylation down-regulates activity | 22952866 | SIGNOR-278285 |
| PTK2 | ARHGEF28 | – | phosphorylation up-regulates activity | 21643014 | SIGNOR-279271 | |
| PTK2 | SH3GL1 | Tyr315 | QPSCKALyDFEPEND | phosphorylation unknown | 16054026 | SIGNOR-139146 |
| PTK2 | NANOG | Tyr174 | QKASAPTyPSLYSSY | phosphorylation up-regulates activity | 22493428 | SIGNOR-276410 |
| PTK2 | NANOG | Tyr35 | ICGPEENyPSLQMSS | phosphorylation up-regulates activity | 22493428 | SIGNOR-276409 |
| PTK2 | ARHGEF12 | – | phosphorylation up-regulates activity | 19273616 | SIGNOR-279310 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTK2 | phosphorylation up-regulates → | ARHGAP42 PTyr376 | phosphorylation up-regulates → | ARHGAP42 | 32331391 | SIGNOR-280097 |
| PTK2 | phosphorylation up-regulates → | ACTN4 PTyr31 | phosphorylation down-regulates ⊣ | ACTN4 | 23454549 | SIGNOR-192195 |
| PTK2 | phosphorylation up-regulates → | ACTN4 PTyr4 | phosphorylation down-regulates ⊣ | ACTN4 | 23454549 | SIGNOR-192199 |
| PTK2 | phosphorylation up-regulates → | ACTN4 PTyr265 | phosphorylation up-regulates → | ACTN4 | 23454549 | SIGNOR-192191 |
| PTK2 | phosphorylation up-regulates → | TRIO PTyr2796 | phosphorylation up-regulates → | TRIO | 12551902 | SIGNOR-249188 |
| PTK2 | phosphorylation up-regulates → | RET PTyr905 | phosphorylation up-regulates → | RET | 21454698 | SIGNOR-173009 |
| PTK2 | phosphorylation up-regulates → | ACTN1 PTyr12 | phosphorylation down-regulates ⊣ | ACTN1 | 23454549 | SIGNOR-192126 |
| PTK2 | phosphorylation up-regulates → | ACTN1 PTyr12 | phosphorylation down-regulates ⊣ | ACTN1 | 11369769 | SIGNOR-108329 |
| PTK2 | phosphorylation up-regulates → | SRC PTyr419 | phosphorylation up-regulates → | SRC | 17828307 | SIGNOR-278452 |
| PTK2 | phosphorylation up-regulates → | ATP2B4 PTyr1176 | phosphorylation up-regulates → | ATP2B4 | 12540962 | SIGNOR-263194 |
| PTK2 | phosphorylation up-regulates → | SHC1 PTyr427 | phosphorylation up-regulates → | SHC1 | 9566877 | SIGNOR-259854 |
| PTK2 | phosphorylation up-regulates → | CTNNB1 PTyr142 | phosphorylation down-regulates ⊣ | CTNNB1 | 22264731 | SIGNOR-261946 |
| PTK2 | phosphorylation up-regulates → | PXN PTyr118 | phosphorylation up-regulates → | PXN | 15688067 | SIGNOR-28243 |
| PTK2 | phosphorylation up-regulates → | PXN PTyr31 | phosphorylation up-regulates → | PXN | 15688067 | SIGNOR-28247 |
| PTK2 | phosphorylation up-regulates → | BCAR1 PTyr664 | phosphorylation down-regulates ⊣ | BCAR1 | 11604500 | SIGNOR-249111 |
| PTK2 | phosphorylation up-regulates → | BCAR1 PTyr666 | phosphorylation down-regulates ⊣ | BCAR1 | 11604500 | SIGNOR-249112 |
| PTK2 | phosphorylation up-regulates → | PTK2 PTyr397 | phosphorylation up-regulates → | PTK2 | 10816598 | SIGNOR-77434 |
| PTK2 | phosphorylation up-regulates → | PTK2 PTyr407 | phosphorylation up-regulates → | PTK2 | 15694384 | SIGNOR-133837 |
| PTK2 | phosphorylation up-regulates → | PTK2 PTyr576 | phosphorylation up-regulates → | PTK2 | 15694384 | SIGNOR-133841 |
| PTK2 | phosphorylation up-regulates → | PTK2 PTyr577 | phosphorylation up-regulates → | PTK2 | 15694384 | SIGNOR-133845 |
| PTK2 | phosphorylation up-regulates → | PTK2 PTyr861 | phosphorylation up-regulates → | PTK2 | 15694384 | SIGNOR-133849 |
| PTK2 | phosphorylation up-regulates → | PTK2 PTyr397 | phosphorylation up-regulates → | PTK2 | 17828307 | SIGNOR-157763 |
| PTK2 | phosphorylation up-regulates → | PTK2 PTyr576 | phosphorylation up-regulates → | PTK2 | 7529876 | SIGNOR-27875 |
| PTK2 | phosphorylation up-regulates → | PTK2 PTyr577 | phosphorylation up-regulates → | PTK2 | 7529876 | SIGNOR-27879 |
| PTK2 | phosphorylation up-regulates → | CTTN PTyr421 | phosphorylation down-regulates ⊣ | CTTN | 22952866 | SIGNOR-278284 |
| PTK2 | phosphorylation up-regulates → | CTTN PTyr470 | phosphorylation down-regulates ⊣ | CTTN | 22952866 | SIGNOR-278283 |
| PTK2 | phosphorylation up-regulates → | CTTN PTyr486 | phosphorylation down-regulates ⊣ | CTTN | 22952866 | SIGNOR-278285 |
| PTK2 | phosphorylation up-regulates → | SH3GL1 PTyr315 | phosphorylation down-regulates ⊣ | SH3GL1 | 16054026 | SIGNOR-139146 |
| PTK2 | phosphorylation up-regulates → | NANOG PTyr174 | phosphorylation up-regulates → | NANOG | 22493428 | SIGNOR-276410 |
| PTK2 | phosphorylation up-regulates → | NANOG PTyr35 | phosphorylation up-regulates → | NANOG | 22493428 | SIGNOR-276409 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTK2 | phosphorylation → up-regulates activity | ARHGAP42 | SIGNOR-280097 |
| PTK2 | phosphorylation → up-regulates activity | WASL | SIGNOR-278977 |
| PTK2 | phosphorylation → up-regulates activity | PLD2 | SIGNOR-279480 |
| PTK2 | phosphorylation down-regulates | ACTN4 | SIGNOR-192195 |
| PTK2 | phosphorylation down-regulates | ACTN4 | SIGNOR-192199 |
| PTK2 | phosphorylation → up-regulates | ACTN4 | SIGNOR-192191 |
| PTK2 | phosphorylation → up-regulates activity | TRIO | SIGNOR-249188 |
| PTK2 | phosphorylation → up-regulates | RET | SIGNOR-173009 |
| PTK2 | phosphorylation → up-regulates quantity | IGF1R | SIGNOR-279565 |
| PTK2 | phosphorylation down-regulates | ACTN1 | SIGNOR-192126 |
| PTK2 | phosphorylation → down-regulates activity | ACTN1 | SIGNOR-108329 |
| PTK2 | phosphorylation → up-regulates activity | SRC | SIGNOR-278452 |
| PTK2 | phosphorylation → up-regulates activity | ATP2B4 | SIGNOR-263194 |
| PTK2 | phosphorylation → up-regulates activity | MYL9 | SIGNOR-280098 |
| PTK2 | phosphorylation → up-regulates activity | SHC1 | SIGNOR-259854 |
| PTK2 | phosphorylation → unknown | CTNNB1 | SIGNOR-261946 |
| PTK2 | phosphorylation → up-regulates activity | YAP1 | SIGNOR-280099 |
| PTK2 | phosphorylation → up-regulates activity | PXN | SIGNOR-28243 |
| PTK2 | phosphorylation → up-regulates activity | PXN | SIGNOR-28247 |
| PTK2 | phosphorylation → up-regulates activity | GSK3B | SIGNOR-278986 |
| PTK2 | phosphorylation → unknown | BCAR1 | SIGNOR-249111 |
| PTK2 | phosphorylation → unknown | BCAR1 | SIGNOR-249112 |
| PTK2 | phosphorylation → up-regulates activity | RAC1 | SIGNOR-279652 |
| PTK2 | phosphorylation → up-regulates | PTK2 | SIGNOR-77434 |
| PTK2 | phosphorylation → up-regulates | PTK2 | SIGNOR-133837 |
| PTK2 | phosphorylation → up-regulates | PTK2 | SIGNOR-133841 |
| PTK2 | phosphorylation → up-regulates | PTK2 | SIGNOR-133845 |
| PTK2 | phosphorylation → up-regulates | PTK2 | SIGNOR-133849 |
| PTK2 | phosphorylation → up-regulates | PTK2 | SIGNOR-157763 |
| PTK2 | phosphorylation → up-regulates | PTK2 | SIGNOR-27875 |
| PTK2 | phosphorylation → up-regulates | PTK2 | SIGNOR-27879 |
| PTK2 | phosphorylation → down-regulates activity | CTTN | SIGNOR-278284 |
| PTK2 | phosphorylation → down-regulates activity | CTTN | SIGNOR-278283 |
| PTK2 | phosphorylation → down-regulates activity | CTTN | SIGNOR-278285 |
| PTK2 | phosphorylation → up-regulates activity | ARHGEF28 | SIGNOR-279271 |
| PTK2 | phosphorylation → unknown | SH3GL1 | SIGNOR-139146 |
| PTK2 | phosphorylation → up-regulates activity | NANOG | SIGNOR-276410 |
| PTK2 | phosphorylation → up-regulates activity | NANOG | SIGNOR-276409 |
| PTK2 | phosphorylation → up-regulates activity | ARHGEF12 | SIGNOR-279310 |