| Name | PTK2 |
| ID | Q05397 |
| Role | substrate |
| Enzymatic Domains |
FERM 35-355 PROSITE-ProRule
Protein kinase 422-680 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT1 | PTK2 | Thr700 | MESRRQAtVSWDSGG | phosphorylation up-regulates activity | 31138602 | SIGNOR-279777 |
| PTK2 | PTK2 | Tyr407 | IIDEEDTyTMPSTRD | phosphorylation up-regulates | 15694384 | SIGNOR-133837 |
| AKT1 | PTK2 | Ser517 | FLQVRKYsLDLASLI | phosphorylation up-regulates activity | 31138602 | SIGNOR-279774 |
| INSR | PTK2 | Tyr577 | YMEDSTYyKASKGKL | phosphorylation up-regulates activity | 9507031 | SIGNOR-251324 |
| MET | PTK2 | Tyr577 | YMEDSTYyKASKGKL | phosphorylation up-regulates | 16782899 | SIGNOR-147195 |
| PTPN1 | PTK2 | Tyr397 | SVSETDDyAEIIDEE | dephosphorylation down-regulates activity | 16291744 | SIGNOR-248431 |
| DUSP3 | PTK2 | – | dephosphorylation down-regulates activity | 28759036 | SIGNOR-277033 | |
| FER | PTK2 | Tyr577 | YMEDSTYyKASKGKL | phosphorylation up-regulates activity | 19339212 | SIGNOR-279409 |
| PTK6 | PTK2 | Tyr861 | PIGNQHIyQPVGKPD | phosphorylation up-regulates activity | 23027128 | SIGNOR-278428 |
| PTPN12 | PTK2 | Tyr397 | SVSETDDyAEIIDEE | dephosphorylation down-regulates activity | 19595712 | SIGNOR-248661 |
| CDK5 | PTK2 | Ser732 | SSEGFYPsPQHMVQT | phosphorylation up-regulates | 12941275 | SIGNOR-86223 |
| PTPRG | PTK2 | Tyr577 | YMEDSTYyKASKGKL | dephosphorylation down-regulates activity | 25624455 | SIGNOR-254718 |
| SRC | PTK2 | Tyr576 | RYMEDSTyYKASKGK | phosphorylation up-regulates | 15735019 | SIGNOR-150484 |
| PTPRG | PTK2 | Tyr861 | PIGNQHIyQPVGKPD | dephosphorylation down-regulates activity | 25624455 | SIGNOR-254720 |
| PTPN12 | PTK2 | – | dephosphorylation down-regulates | 11432829 | SIGNOR-109035 | |
| PTK2B | PTK2 | Tyr407 | IIDEEDTyTMPSTRD | phosphorylation up-regulates | 16760434 | SIGNOR-147070 |
| PTK2 | PTK2 | Tyr576 | RYMEDSTyYKASKGK | phosphorylation up-regulates | 15694384 | SIGNOR-133841 |
| AKT1 | PTK2 | Thr700 | MESRRQAtVSWDSGG | phosphorylation up-regulates activity | 23264741 | SIGNOR-276436 |
| RET | PTK2 | Tyr925 | DRSNDKVyENVTGLV | phosphorylation up-regulates | 21454698 | SIGNOR-173021 |
| PTPRG | PTK2 | Tyr397 | SVSETDDyAEIIDEE | dephosphorylation up-regulates activity | 25624455 | SIGNOR-254717 |
| PTK2 | PTK2 | Tyr397 | SVSETDDyAEIIDEE | phosphorylation up-regulates | 17828307 | SIGNOR-157763 |
| PTEN | PTK2 | Tyr397 | SVSETDDyAEIIDEE | dephosphorylation down-regulates activity | 10400703 | SIGNOR-248547 |
| PDGFRB | PTK2 | Tyr5 | yLDPNLNH | phosphorylation up-regulates | 20802513 | SIGNOR-167662 |
| PTK2 | PTK2 | Tyr576 | RYMEDSTyYKASKGK | phosphorylation up-regulates | 7529876 | SIGNOR-27875 |
| FYN | PTK2 | Tyr397 | SVSETDDyAEIIDEE | phosphorylation up-regulates activity | 19917775 | SIGNOR-278441 |
| RET | PTK2 | Tyr577 | YMEDSTYyKASKGKL | phosphorylation up-regulates | 21454698 | SIGNOR-173017 |
| PDGFRA | PTK2 | Tyr194 | ALEKKSNyEVLEKDV | phosphorylation up-regulates activity | 20802513 | SIGNOR-259400 |
| SRC | PTK2 | Tyr407 | IIDEEDTyTMPSTRD | phosphorylation up-regulates | 15735019 | SIGNOR-150480 |
| MET | PTK2 | Tyr397 | SVSETDDyAEIIDEE | phosphorylation up-regulates | 16782899 | SIGNOR-147183 |
| SRC | PTK2 | Tyr861 | PIGNQHIyQPVGKPD | phosphorylation up-regulates | 15735019 | SIGNOR-150492 |
| ACP1 | PTK2 | – | dephosphorylation down-regulates activity | 12815062 | SIGNOR-277064 | |
| PTPRG | PTK2 | Tyr576 | RYMEDSTyYKASKGK | dephosphorylation up-regulates activity | 25624455 | SIGNOR-254719 |
| RTKs | PTK2 | – | phosphorylation up-regulates activity | 30889378 | SIGNOR-259030 | |
| MET | PTK2 | Tyr925 | DRSNDKVyENVTGLV | phosphorylation up-regulates | 16782899 | SIGNOR-147203 |
| PTK2 | PTK2 | Tyr577 | YMEDSTYyKASKGKL | phosphorylation up-regulates | 15694384 | SIGNOR-133845 |
| FGR | PTK2 | Tyr925 | DRSNDKVyENVTGLV | phosphorylation up-regulates | 12387730 | SIGNOR-94405 |
| MET | PTK2 | Tyr194 | ALEKKSNyEVLEKDV | phosphorylation up-regulates | 16782899 | SIGNOR-147179 |
| SRC | PTK2 | Tyr861 | PIGNQHIyQPVGKPD | phosphorylation up-regulates | 17289681 | SIGNOR-152971 |
| CAMK2A | PTK2 | Ser843 | DVRLSRGsIDREDGS | phosphorylation up-regulates | 15845548 | SIGNOR-135631 |
| SRC | PTK2 | Tyr742 | HMVQTNHyQVSGYPG | phosphorylation up-regulates | 17289681 | SIGNOR-152967 |
| AKT1 | PTK2 | Ser695 | EERMRMEsRRQATVS | phosphorylation up-regulates activity | 23264741 | SIGNOR-276437 |
| MET | PTK2 | Tyr861 | PIGNQHIyQPVGKPD | phosphorylation up-regulates | 16782899 | SIGNOR-147199 |
| LRRK2 | PTK2 | Thr474 | KFLQEALtMRQFDHP | phosphorylation down-regulates activity | 26365310 | SIGNOR-278281 |
| SRC | PTK2 | – | phosphorylation up-regulates | 17828307 | SIGNOR-157767 | |
| AURKA | PTK2 | – | phosphorylation up-regulates activity | 25501815 | SIGNOR-280188 | |
| CRK | PTK2 | Tyr397 | SVSETDDyAEIIDEE | phosphorylation up-regulates activity | 11314030 | SIGNOR-250777 |
| SRC | PTK2 | Tyr397 | SVSETDDyAEIIDEE | phosphorylation up-regulates | 15735019 | SIGNOR-150476 |
| PTK2 | PTK2 | Tyr861 | PIGNQHIyQPVGKPD | phosphorylation up-regulates | 15694384 | SIGNOR-133849 |
| PTK2 | PTK2 | Tyr577 | YMEDSTYyKASKGKL | phosphorylation up-regulates | 7529876 | SIGNOR-27879 |
| MAPK7 | PTK2 | Tyr397 | SVSETDDyAEIIDEE | phosphorylation up-regulates activity | 33981002 | SIGNOR-279304 |
| AKT1 | PTK2 | Ser601 | INFRRFTsASDVWMF | phosphorylation up-regulates activity | 31138602 | SIGNOR-279775 |
| AKT1 | PTK2 | Ser695 | EERMRMEsRRQATVS | phosphorylation up-regulates activity | 31138602 | SIGNOR-279776 |
| EGFR | PTK2 | Tyr5 | yLDPNLNH | phosphorylation up-regulates | 20802513 | SIGNOR-167650 |
| SRC | PTK2 | Tyr577 | YMEDSTYyKASKGKL | phosphorylation up-regulates | 15735019 | SIGNOR-134212 |
| RET | PTK2 | Tyr576 | RYMEDSTyYKASKGK | phosphorylation up-regulates | 21454698 | SIGNOR-173013 |
| PTPN1 | PTK2 | – | dephosphorylation down-regulates | 16291744 | SIGNOR-141637 | |
| MET | PTK2 | Tyr407 | IIDEEDTyTMPSTRD | phosphorylation up-regulates | 16782899 | SIGNOR-147187 |
| MELK | PTK2 | – | phosphorylation up-regulates activity | 24885567 | SIGNOR-279230 | |
| PTK2 | PTK2 | Tyr397 | SVSETDDyAEIIDEE | phosphorylation up-regulates | 10816598 | SIGNOR-77434 |
| BMX | PTK2 | Tyr577 | YMEDSTYyKASKGKL | phosphorylation up-regulates | 23716717 | SIGNOR-202139 |
| ERBB2 | PTK2 | Tyr397 | SVSETDDyAEIIDEE | phosphorylation up-regulates activity | 27638858 | SIGNOR-278475 |
| MET | PTK2 | Tyr576 | RYMEDSTyYKASKGK | phosphorylation up-regulates | 16782899 | SIGNOR-147191 |
| MAPK7 | PTK2 | Ser910 | KLQPQEIsPPPTANL | phosphorylation up-regulates quantity | 32144580 | SIGNOR-279305 |
| PTPN11 | PTK2 | Tyr577 | YMEDSTYyKASKGKL | dephosphorylation down-regulates | 16920701 | SIGNOR-148926 |
| MET | PTK2 | Tyr194 | ALEKKSNyEVLEKDV | phosphorylation up-regulates | 20802513 | SIGNOR-167654 |
| EGFR | PTK2 | Tyr194 | ALEKKSNyEVLEKDV | phosphorylation up-regulates | 20802513 | SIGNOR-167646 |
| INSR | PTK2 | Tyr576 | RYMEDSTyYKASKGK | phosphorylation up-regulates activity | 9507031 | SIGNOR-251323 |
| PDGFRB | PTK2 | Tyr194 | ALEKKSNyEVLEKDV | phosphorylation up-regulates | 20802513 | SIGNOR-167658 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT1 | phosphorylation up-regulates → | PTK2 PThr700 | phosphorylation up-regulates → | PTK2 | 31138602 | SIGNOR-279777 |
| PTK2 | phosphorylation up-regulates → | PTK2 PTyr407 | phosphorylation up-regulates → | PTK2 | 15694384 | SIGNOR-133837 |
| AKT1 | phosphorylation up-regulates → | PTK2 PSer517 | phosphorylation up-regulates → | PTK2 | 31138602 | SIGNOR-279774 |
| INSR | phosphorylation up-regulates → | PTK2 PTyr577 | phosphorylation up-regulates → | PTK2 | 9507031 | SIGNOR-251324 |
| MET | phosphorylation up-regulates → | PTK2 PTyr577 | phosphorylation up-regulates → | PTK2 | 16782899 | SIGNOR-147195 |
| PTPN1 | dephosphorylation down-regulates ⊣ | PTK2 PTyr397 | dephosphorylation up-regulates → | PTK2 | 16291744 | SIGNOR-248431 |
| FER | phosphorylation up-regulates → | PTK2 PTyr577 | phosphorylation up-regulates → | PTK2 | 19339212 | SIGNOR-279409 |
| PTK6 | phosphorylation up-regulates → | PTK2 PTyr861 | phosphorylation up-regulates → | PTK2 | 23027128 | SIGNOR-278428 |
| PTPN12 | dephosphorylation down-regulates ⊣ | PTK2 PTyr397 | dephosphorylation up-regulates → | PTK2 | 19595712 | SIGNOR-248661 |
| CDK5 | phosphorylation up-regulates → | PTK2 PSer732 | phosphorylation up-regulates → | PTK2 | 12941275 | SIGNOR-86223 |
| PTPRG | dephosphorylation down-regulates ⊣ | PTK2 PTyr577 | dephosphorylation up-regulates → | PTK2 | 25624455 | SIGNOR-254718 |
| SRC | phosphorylation up-regulates → | PTK2 PTyr576 | phosphorylation up-regulates → | PTK2 | 15735019 | SIGNOR-150484 |
| PTPRG | dephosphorylation down-regulates ⊣ | PTK2 PTyr861 | dephosphorylation up-regulates → | PTK2 | 25624455 | SIGNOR-254720 |
| PTK2B | phosphorylation up-regulates → | PTK2 PTyr407 | phosphorylation up-regulates → | PTK2 | 16760434 | SIGNOR-147070 |
| PTK2 | phosphorylation up-regulates → | PTK2 PTyr576 | phosphorylation up-regulates → | PTK2 | 15694384 | SIGNOR-133841 |
| AKT1 | phosphorylation up-regulates → | PTK2 PThr700 | phosphorylation up-regulates → | PTK2 | 23264741 | SIGNOR-276436 |
| RET | phosphorylation up-regulates → | PTK2 PTyr925 | phosphorylation up-regulates → | PTK2 | 21454698 | SIGNOR-173021 |
| PTPRG | dephosphorylation down-regulates ⊣ | PTK2 PTyr397 | dephosphorylation down-regulates ⊣ | PTK2 | 25624455 | SIGNOR-254717 |
| PTK2 | phosphorylation up-regulates → | PTK2 PTyr397 | phosphorylation up-regulates → | PTK2 | 17828307 | SIGNOR-157763 |
| PTEN | dephosphorylation down-regulates ⊣ | PTK2 PTyr397 | dephosphorylation up-regulates → | PTK2 | 10400703 | SIGNOR-248547 |
| PDGFRB | phosphorylation up-regulates → | PTK2 PTyr5 | phosphorylation up-regulates → | PTK2 | 20802513 | SIGNOR-167662 |
| PTK2 | phosphorylation up-regulates → | PTK2 PTyr576 | phosphorylation up-regulates → | PTK2 | 7529876 | SIGNOR-27875 |
| FYN | phosphorylation up-regulates → | PTK2 PTyr397 | phosphorylation up-regulates → | PTK2 | 19917775 | SIGNOR-278441 |
| RET | phosphorylation up-regulates → | PTK2 PTyr577 | phosphorylation up-regulates → | PTK2 | 21454698 | SIGNOR-173017 |
| PDGFRA | phosphorylation up-regulates → | PTK2 PTyr194 | phosphorylation up-regulates → | PTK2 | 20802513 | SIGNOR-259400 |
| SRC | phosphorylation up-regulates → | PTK2 PTyr407 | phosphorylation up-regulates → | PTK2 | 15735019 | SIGNOR-150480 |
| MET | phosphorylation up-regulates → | PTK2 PTyr397 | phosphorylation up-regulates → | PTK2 | 16782899 | SIGNOR-147183 |
| SRC | phosphorylation up-regulates → | PTK2 PTyr861 | phosphorylation up-regulates → | PTK2 | 15735019 | SIGNOR-150492 |
| PTPRG | dephosphorylation down-regulates ⊣ | PTK2 PTyr576 | dephosphorylation down-regulates ⊣ | PTK2 | 25624455 | SIGNOR-254719 |
| MET | phosphorylation up-regulates → | PTK2 PTyr925 | phosphorylation up-regulates → | PTK2 | 16782899 | SIGNOR-147203 |
| PTK2 | phosphorylation up-regulates → | PTK2 PTyr577 | phosphorylation up-regulates → | PTK2 | 15694384 | SIGNOR-133845 |
| FGR | phosphorylation up-regulates → | PTK2 PTyr925 | phosphorylation up-regulates → | PTK2 | 12387730 | SIGNOR-94405 |
| MET | phosphorylation up-regulates → | PTK2 PTyr194 | phosphorylation up-regulates → | PTK2 | 16782899 | SIGNOR-147179 |
| SRC | phosphorylation up-regulates → | PTK2 PTyr861 | phosphorylation up-regulates → | PTK2 | 17289681 | SIGNOR-152971 |
| CAMK2A | phosphorylation up-regulates → | PTK2 PSer843 | phosphorylation up-regulates → | PTK2 | 15845548 | SIGNOR-135631 |
| SRC | phosphorylation up-regulates → | PTK2 PTyr742 | phosphorylation up-regulates → | PTK2 | 17289681 | SIGNOR-152967 |
| AKT1 | phosphorylation up-regulates → | PTK2 PSer695 | phosphorylation up-regulates → | PTK2 | 23264741 | SIGNOR-276437 |
| MET | phosphorylation up-regulates → | PTK2 PTyr861 | phosphorylation up-regulates → | PTK2 | 16782899 | SIGNOR-147199 |
| LRRK2 | phosphorylation up-regulates → | PTK2 PThr474 | phosphorylation down-regulates ⊣ | PTK2 | 26365310 | SIGNOR-278281 |
| CRK | phosphorylation up-regulates → | PTK2 PTyr397 | phosphorylation up-regulates → | PTK2 | 11314030 | SIGNOR-250777 |
| SRC | phosphorylation up-regulates → | PTK2 PTyr397 | phosphorylation up-regulates → | PTK2 | 15735019 | SIGNOR-150476 |
| PTK2 | phosphorylation up-regulates → | PTK2 PTyr861 | phosphorylation up-regulates → | PTK2 | 15694384 | SIGNOR-133849 |
| PTK2 | phosphorylation up-regulates → | PTK2 PTyr577 | phosphorylation up-regulates → | PTK2 | 7529876 | SIGNOR-27879 |
| MAPK7 | phosphorylation up-regulates → | PTK2 PTyr397 | phosphorylation up-regulates → | PTK2 | 33981002 | SIGNOR-279304 |
| AKT1 | phosphorylation up-regulates → | PTK2 PSer601 | phosphorylation up-regulates → | PTK2 | 31138602 | SIGNOR-279775 |
| AKT1 | phosphorylation up-regulates → | PTK2 PSer695 | phosphorylation up-regulates → | PTK2 | 31138602 | SIGNOR-279776 |
| EGFR | phosphorylation up-regulates → | PTK2 PTyr5 | phosphorylation up-regulates → | PTK2 | 20802513 | SIGNOR-167650 |
| SRC | phosphorylation up-regulates → | PTK2 PTyr577 | phosphorylation up-regulates → | PTK2 | 15735019 | SIGNOR-134212 |
| RET | phosphorylation up-regulates → | PTK2 PTyr576 | phosphorylation up-regulates → | PTK2 | 21454698 | SIGNOR-173013 |
| MET | phosphorylation up-regulates → | PTK2 PTyr407 | phosphorylation up-regulates → | PTK2 | 16782899 | SIGNOR-147187 |
| PTK2 | phosphorylation up-regulates → | PTK2 PTyr397 | phosphorylation up-regulates → | PTK2 | 10816598 | SIGNOR-77434 |
| BMX | phosphorylation up-regulates → | PTK2 PTyr577 | phosphorylation up-regulates → | PTK2 | 23716717 | SIGNOR-202139 |
| ERBB2 | phosphorylation up-regulates → | PTK2 PTyr397 | phosphorylation up-regulates → | PTK2 | 27638858 | SIGNOR-278475 |
| MET | phosphorylation up-regulates → | PTK2 PTyr576 | phosphorylation up-regulates → | PTK2 | 16782899 | SIGNOR-147191 |
| MAPK7 | phosphorylation up-regulates → | PTK2 PSer910 | phosphorylation up-regulates → | PTK2 | 32144580 | SIGNOR-279305 |
| PTPN11 | dephosphorylation down-regulates ⊣ | PTK2 PTyr577 | dephosphorylation up-regulates → | PTK2 | 16920701 | SIGNOR-148926 |
| MET | phosphorylation up-regulates → | PTK2 PTyr194 | phosphorylation up-regulates → | PTK2 | 20802513 | SIGNOR-167654 |
| EGFR | phosphorylation up-regulates → | PTK2 PTyr194 | phosphorylation up-regulates → | PTK2 | 20802513 | SIGNOR-167646 |
| INSR | phosphorylation up-regulates → | PTK2 PTyr576 | phosphorylation up-regulates → | PTK2 | 9507031 | SIGNOR-251323 |
| PDGFRB | phosphorylation up-regulates → | PTK2 PTyr194 | phosphorylation up-regulates → | PTK2 | 20802513 | SIGNOR-167658 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AKT1 | phosphorylation → up-regulates activity | PTK2 | SIGNOR-279777 |
| PTK2 | phosphorylation → up-regulates | PTK2 | SIGNOR-133837 |
| AKT1 | phosphorylation → up-regulates activity | PTK2 | SIGNOR-279774 |
| INSR | phosphorylation → up-regulates activity | PTK2 | SIGNOR-251324 |
| MET | phosphorylation → up-regulates | PTK2 | SIGNOR-147195 |
| PTPN1 | dephosphorylation → down-regulates activity | PTK2 | SIGNOR-248431 |
| DUSP3 | dephosphorylation → down-regulates activity | PTK2 | SIGNOR-277033 |
| FER | phosphorylation → up-regulates activity | PTK2 | SIGNOR-279409 |
| PTK6 | phosphorylation → up-regulates activity | PTK2 | SIGNOR-278428 |
| PTPN12 | dephosphorylation → down-regulates activity | PTK2 | SIGNOR-248661 |
| CDK5 | phosphorylation → up-regulates | PTK2 | SIGNOR-86223 |
| PTPRG | dephosphorylation → down-regulates activity | PTK2 | SIGNOR-254718 |
| SRC | phosphorylation → up-regulates | PTK2 | SIGNOR-150484 |
| PTPRG | dephosphorylation → down-regulates activity | PTK2 | SIGNOR-254720 |
| PTPN12 | dephosphorylation down-regulates | PTK2 | SIGNOR-109035 |
| PTK2B | phosphorylation → up-regulates | PTK2 | SIGNOR-147070 |
| PTK2 | phosphorylation → up-regulates | PTK2 | SIGNOR-133841 |
| AKT1 | phosphorylation → up-regulates activity | PTK2 | SIGNOR-276436 |
| RET | phosphorylation → up-regulates | PTK2 | SIGNOR-173021 |
| PTPRG | dephosphorylation → up-regulates activity | PTK2 | SIGNOR-254717 |
| PTK2 | phosphorylation → up-regulates | PTK2 | SIGNOR-157763 |
| PTEN | dephosphorylation → down-regulates activity | PTK2 | SIGNOR-248547 |
| PDGFRB | phosphorylation → up-regulates | PTK2 | SIGNOR-167662 |
| PTK2 | phosphorylation → up-regulates | PTK2 | SIGNOR-27875 |
| FYN | phosphorylation → up-regulates activity | PTK2 | SIGNOR-278441 |
| RET | phosphorylation → up-regulates | PTK2 | SIGNOR-173017 |
| PDGFRA | phosphorylation → up-regulates activity | PTK2 | SIGNOR-259400 |
| SRC | phosphorylation → up-regulates | PTK2 | SIGNOR-150480 |
| MET | phosphorylation → up-regulates | PTK2 | SIGNOR-147183 |
| SRC | phosphorylation → up-regulates | PTK2 | SIGNOR-150492 |
| ACP1 | dephosphorylation → down-regulates activity | PTK2 | SIGNOR-277064 |
| PTPRG | dephosphorylation → up-regulates activity | PTK2 | SIGNOR-254719 |
| RTKs | phosphorylation → up-regulates activity | PTK2 | SIGNOR-259030 |
| MET | phosphorylation → up-regulates | PTK2 | SIGNOR-147203 |
| PTK2 | phosphorylation → up-regulates | PTK2 | SIGNOR-133845 |
| FGR | phosphorylation → up-regulates | PTK2 | SIGNOR-94405 |
| MET | phosphorylation → up-regulates | PTK2 | SIGNOR-147179 |
| SRC | phosphorylation → up-regulates | PTK2 | SIGNOR-152971 |
| CAMK2A | phosphorylation → up-regulates | PTK2 | SIGNOR-135631 |
| SRC | phosphorylation → up-regulates | PTK2 | SIGNOR-152967 |
| AKT1 | phosphorylation → up-regulates activity | PTK2 | SIGNOR-276437 |
| MET | phosphorylation → up-regulates | PTK2 | SIGNOR-147199 |
| LRRK2 | phosphorylation → down-regulates activity | PTK2 | SIGNOR-278281 |
| SRC | phosphorylation → up-regulates | PTK2 | SIGNOR-157767 |
| AURKA | phosphorylation → up-regulates activity | PTK2 | SIGNOR-280188 |
| CRK | phosphorylation → up-regulates activity | PTK2 | SIGNOR-250777 |
| SRC | phosphorylation → up-regulates | PTK2 | SIGNOR-150476 |
| PTK2 | phosphorylation → up-regulates | PTK2 | SIGNOR-133849 |
| PTK2 | phosphorylation → up-regulates | PTK2 | SIGNOR-27879 |
| MAPK7 | phosphorylation → up-regulates activity | PTK2 | SIGNOR-279304 |
| AKT1 | phosphorylation → up-regulates activity | PTK2 | SIGNOR-279775 |
| AKT1 | phosphorylation → up-regulates activity | PTK2 | SIGNOR-279776 |
| EGFR | phosphorylation → up-regulates | PTK2 | SIGNOR-167650 |
| SRC | phosphorylation → up-regulates | PTK2 | SIGNOR-134212 |
| RET | phosphorylation → up-regulates | PTK2 | SIGNOR-173013 |
| PTPN1 | dephosphorylation down-regulates | PTK2 | SIGNOR-141637 |
| MET | phosphorylation → up-regulates | PTK2 | SIGNOR-147187 |
| MELK | phosphorylation → up-regulates activity | PTK2 | SIGNOR-279230 |
| PTK2 | phosphorylation → up-regulates | PTK2 | SIGNOR-77434 |
| BMX | phosphorylation → up-regulates | PTK2 | SIGNOR-202139 |
| ERBB2 | phosphorylation → up-regulates activity | PTK2 | SIGNOR-278475 |
| MET | phosphorylation → up-regulates | PTK2 | SIGNOR-147191 |
| MAPK7 | phosphorylation → up-regulates quantity | PTK2 | SIGNOR-279305 |
| PTPN11 | dephosphorylation down-regulates | PTK2 | SIGNOR-148926 |
| MET | phosphorylation → up-regulates | PTK2 | SIGNOR-167654 |
| EGFR | phosphorylation → up-regulates | PTK2 | SIGNOR-167646 |
| INSR | phosphorylation → up-regulates activity | PTK2 | SIGNOR-251323 |
| PDGFRB | phosphorylation → up-regulates | PTK2 | SIGNOR-167658 |