| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PDGFRA | PTK2 | Tyr194 | ALEKKSNyEVLEKDV | phosphorylation up-regulates activity | 20802513 | SIGNOR-259400 |
| MET | PTK2 | Tyr194 | ALEKKSNyEVLEKDV | phosphorylation up-regulates | 16782899 | SIGNOR-147179 |
| MET | PTK2 | Tyr194 | ALEKKSNyEVLEKDV | phosphorylation up-regulates | 20802513 | SIGNOR-167654 |
| EGFR | PTK2 | Tyr194 | ALEKKSNyEVLEKDV | phosphorylation up-regulates | 20802513 | SIGNOR-167646 |
| PDGFRB | PTK2 | Tyr194 | ALEKKSNyEVLEKDV | phosphorylation up-regulates | 20802513 | SIGNOR-167658 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PDGFRA | phosphorylation up-regulates → | PTK2 PTyr194 | phosphorylation up-regulates → | PTK2 | 20802513 | SIGNOR-259400 |
| MET | phosphorylation up-regulates → | PTK2 PTyr194 | phosphorylation up-regulates → | PTK2 | 16782899 | SIGNOR-147179 |
| MET | phosphorylation up-regulates → | PTK2 PTyr194 | phosphorylation up-regulates → | PTK2 | 20802513 | SIGNOR-167654 |
| EGFR | phosphorylation up-regulates → | PTK2 PTyr194 | phosphorylation up-regulates → | PTK2 | 20802513 | SIGNOR-167646 |
| PDGFRB | phosphorylation up-regulates → | PTK2 PTyr194 | phosphorylation up-regulates → | PTK2 | 20802513 | SIGNOR-167658 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PDGFRA | phosphorylation → up-regulates activity | PTK2 | SIGNOR-259400 |
| MET | phosphorylation → up-regulates | PTK2 | SIGNOR-147179 |
| MET | phosphorylation → up-regulates | PTK2 | SIGNOR-167654 |
| EGFR | phosphorylation → up-regulates | PTK2 | SIGNOR-167646 |
| PDGFRB | phosphorylation → up-regulates | PTK2 | SIGNOR-167658 |
