| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTK2 | PTK2 | Tyr861 | PIGNQHIyQPVGKPD | phosphorylation up-regulates | 15694384 | SIGNOR-133849 |
| PTK6 | PTK2 | Tyr861 | PIGNQHIyQPVGKPD | phosphorylation up-regulates activity | 23027128 | SIGNOR-278428 |
| PTPRG | PTK2 | Tyr861 | PIGNQHIyQPVGKPD | dephosphorylation down-regulates activity | 25624455 | SIGNOR-254720 |
| SRC | PTK2 | Tyr861 | PIGNQHIyQPVGKPD | phosphorylation up-regulates | 15735019 | SIGNOR-150492 |
| SRC | PTK2 | Tyr861 | PIGNQHIyQPVGKPD | phosphorylation up-regulates | 17289681 | SIGNOR-152971 |
| MET | PTK2 | Tyr861 | PIGNQHIyQPVGKPD | phosphorylation up-regulates | 16782899 | SIGNOR-147199 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTK2 | phosphorylation up-regulates → | PTK2 PTyr861 | phosphorylation up-regulates → | PTK2 | 15694384 | SIGNOR-133849 |
| PTK6 | phosphorylation up-regulates → | PTK2 PTyr861 | phosphorylation up-regulates → | PTK2 | 23027128 | SIGNOR-278428 |
| PTPRG | dephosphorylation down-regulates ⊣ | PTK2 PTyr861 | dephosphorylation up-regulates → | PTK2 | 25624455 | SIGNOR-254720 |
| SRC | phosphorylation up-regulates → | PTK2 PTyr861 | phosphorylation up-regulates → | PTK2 | 15735019 | SIGNOR-150492 |
| SRC | phosphorylation up-regulates → | PTK2 PTyr861 | phosphorylation up-regulates → | PTK2 | 17289681 | SIGNOR-152971 |
| MET | phosphorylation up-regulates → | PTK2 PTyr861 | phosphorylation up-regulates → | PTK2 | 16782899 | SIGNOR-147199 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTK2 | phosphorylation → up-regulates | PTK2 | SIGNOR-133849 |
| PTK6 | phosphorylation → up-regulates activity | PTK2 | SIGNOR-278428 |
| PTPRG | dephosphorylation → down-regulates activity | PTK2 | SIGNOR-254720 |
| SRC | phosphorylation → up-regulates | PTK2 | SIGNOR-150492 |
| SRC | phosphorylation → up-regulates | PTK2 | SIGNOR-152971 |
| MET | phosphorylation → up-regulates | PTK2 | SIGNOR-147199 |
