| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CRK | PTK2 | Tyr397 | SVSETDDyAEIIDEE | phosphorylation up-regulates activity | 11314030 | SIGNOR-250777 |
| PTK2 | PTK2 | Tyr397 | SVSETDDyAEIIDEE | phosphorylation up-regulates | 10816598 | SIGNOR-77434 |
| MAPK7 | PTK2 | Tyr397 | SVSETDDyAEIIDEE | phosphorylation up-regulates activity | 33981002 | SIGNOR-279304 |
| SRC | PTK2 | Tyr397 | SVSETDDyAEIIDEE | phosphorylation up-regulates | 15735019 | SIGNOR-150476 |
| FYN | PTK2 | Tyr397 | SVSETDDyAEIIDEE | phosphorylation up-regulates activity | 19917775 | SIGNOR-278441 |
| PTPN12 | PTK2 | Tyr397 | SVSETDDyAEIIDEE | dephosphorylation down-regulates activity | 19595712 | SIGNOR-248661 |
| PTPRG | PTK2 | Tyr397 | SVSETDDyAEIIDEE | dephosphorylation up-regulates activity | 25624455 | SIGNOR-254717 |
| PTK2 | PTK2 | Tyr397 | SVSETDDyAEIIDEE | phosphorylation up-regulates | 17828307 | SIGNOR-157763 |
| PTEN | PTK2 | Tyr397 | SVSETDDyAEIIDEE | dephosphorylation down-regulates activity | 10400703 | SIGNOR-248547 |
| MET | PTK2 | Tyr397 | SVSETDDyAEIIDEE | phosphorylation up-regulates | 16782899 | SIGNOR-147183 |
| PTPN1 | PTK2 | Tyr397 | SVSETDDyAEIIDEE | dephosphorylation down-regulates activity | 16291744 | SIGNOR-248431 |
| ERBB2 | PTK2 | Tyr397 | SVSETDDyAEIIDEE | phosphorylation up-regulates activity | 27638858 | SIGNOR-278475 |
| RHOA | PTK2 | Tyr397 | SVSETDDyAEIIDEE | phosphorylation up-regulates activity | 12087088 | SIGNOR-282607 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CRK | phosphorylation up-regulates → | PTK2 PTyr397 | phosphorylation up-regulates → | PTK2 | 11314030 | SIGNOR-250777 |
| PTK2 | phosphorylation up-regulates → | PTK2 PTyr397 | phosphorylation up-regulates → | PTK2 | 10816598 | SIGNOR-77434 |
| MAPK7 | phosphorylation up-regulates → | PTK2 PTyr397 | phosphorylation up-regulates → | PTK2 | 33981002 | SIGNOR-279304 |
| SRC | phosphorylation up-regulates → | PTK2 PTyr397 | phosphorylation up-regulates → | PTK2 | 15735019 | SIGNOR-150476 |
| FYN | phosphorylation up-regulates → | PTK2 PTyr397 | phosphorylation up-regulates → | PTK2 | 19917775 | SIGNOR-278441 |
| PTPN12 | dephosphorylation down-regulates ⊣ | PTK2 PTyr397 | dephosphorylation up-regulates → | PTK2 | 19595712 | SIGNOR-248661 |
| PTPRG | dephosphorylation down-regulates ⊣ | PTK2 PTyr397 | dephosphorylation down-regulates ⊣ | PTK2 | 25624455 | SIGNOR-254717 |
| PTK2 | phosphorylation up-regulates → | PTK2 PTyr397 | phosphorylation up-regulates → | PTK2 | 17828307 | SIGNOR-157763 |
| PTEN | dephosphorylation down-regulates ⊣ | PTK2 PTyr397 | dephosphorylation up-regulates → | PTK2 | 10400703 | SIGNOR-248547 |
| MET | phosphorylation up-regulates → | PTK2 PTyr397 | phosphorylation up-regulates → | PTK2 | 16782899 | SIGNOR-147183 |
| PTPN1 | dephosphorylation down-regulates ⊣ | PTK2 PTyr397 | dephosphorylation up-regulates → | PTK2 | 16291744 | SIGNOR-248431 |
| ERBB2 | phosphorylation up-regulates → | PTK2 PTyr397 | phosphorylation up-regulates → | PTK2 | 27638858 | SIGNOR-278475 |
| RHOA | phosphorylation up-regulates → | PTK2 PTyr397 | phosphorylation up-regulates → | PTK2 | 12087088 | SIGNOR-282607 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CRK | phosphorylation → up-regulates activity | PTK2 | SIGNOR-250777 |
| PTK2 | phosphorylation → up-regulates | PTK2 | SIGNOR-77434 |
| MAPK7 | phosphorylation → up-regulates activity | PTK2 | SIGNOR-279304 |
| SRC | phosphorylation → up-regulates | PTK2 | SIGNOR-150476 |
| FYN | phosphorylation → up-regulates activity | PTK2 | SIGNOR-278441 |
| PTPN12 | dephosphorylation → down-regulates activity | PTK2 | SIGNOR-248661 |
| PTPRG | dephosphorylation → up-regulates activity | PTK2 | SIGNOR-254717 |
| PTK2 | phosphorylation → up-regulates | PTK2 | SIGNOR-157763 |
| PTEN | dephosphorylation → down-regulates activity | PTK2 | SIGNOR-248547 |
| MET | phosphorylation → up-regulates | PTK2 | SIGNOR-147183 |
| PTPN1 | dephosphorylation → down-regulates activity | PTK2 | SIGNOR-248431 |
| ERBB2 | phosphorylation → up-regulates activity | PTK2 | SIGNOR-278475 |
| RHOA | phosphorylation → up-regulates activity | PTK2 | SIGNOR-282607 |
