| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPRG | PTK2 | Tyr576 | RYMEDSTyYKASKGK | dephosphorylation up-regulates activity | 25624455 | SIGNOR-254719 |
| RET | PTK2 | Tyr576 | RYMEDSTyYKASKGK | phosphorylation up-regulates | 21454698 | SIGNOR-173013 |
| MET | PTK2 | Tyr576 | RYMEDSTyYKASKGK | phosphorylation up-regulates | 16782899 | SIGNOR-147191 |
| INSR | PTK2 | Tyr576 | RYMEDSTyYKASKGK | phosphorylation up-regulates activity | 9507031 | SIGNOR-251323 |
| PTK2 | PTK2 | Tyr576 | RYMEDSTyYKASKGK | phosphorylation up-regulates | 7529876 | SIGNOR-27875 |
| SRC | PTK2 | Tyr576 | RYMEDSTyYKASKGK | phosphorylation up-regulates | 15735019 | SIGNOR-150484 |
| PTK2 | PTK2 | Tyr576 | RYMEDSTyYKASKGK | phosphorylation up-regulates | 15694384 | SIGNOR-133841 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPRG | dephosphorylation down-regulates ⊣ | PTK2 PTyr576 | dephosphorylation down-regulates ⊣ | PTK2 | 25624455 | SIGNOR-254719 |
| RET | phosphorylation up-regulates → | PTK2 PTyr576 | phosphorylation up-regulates → | PTK2 | 21454698 | SIGNOR-173013 |
| MET | phosphorylation up-regulates → | PTK2 PTyr576 | phosphorylation up-regulates → | PTK2 | 16782899 | SIGNOR-147191 |
| INSR | phosphorylation up-regulates → | PTK2 PTyr576 | phosphorylation up-regulates → | PTK2 | 9507031 | SIGNOR-251323 |
| PTK2 | phosphorylation up-regulates → | PTK2 PTyr576 | phosphorylation up-regulates → | PTK2 | 7529876 | SIGNOR-27875 |
| SRC | phosphorylation up-regulates → | PTK2 PTyr576 | phosphorylation up-regulates → | PTK2 | 15735019 | SIGNOR-150484 |
| PTK2 | phosphorylation up-regulates → | PTK2 PTyr576 | phosphorylation up-regulates → | PTK2 | 15694384 | SIGNOR-133841 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPRG | dephosphorylation → up-regulates activity | PTK2 | SIGNOR-254719 |
| RET | phosphorylation → up-regulates | PTK2 | SIGNOR-173013 |
| MET | phosphorylation → up-regulates | PTK2 | SIGNOR-147191 |
| INSR | phosphorylation → up-regulates activity | PTK2 | SIGNOR-251323 |
| PTK2 | phosphorylation → up-regulates | PTK2 | SIGNOR-27875 |
| SRC | phosphorylation → up-regulates | PTK2 | SIGNOR-150484 |
| PTK2 | phosphorylation → up-regulates | PTK2 | SIGNOR-133841 |
