| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| INSR | PTK2 | Tyr577 | YMEDSTYyKASKGKL | phosphorylation up-regulates activity | 9507031 | SIGNOR-251324 |
| FER | PTK2 | Tyr577 | YMEDSTYyKASKGKL | phosphorylation up-regulates activity | 19339212 | SIGNOR-279409 |
| BMX | PTK2 | Tyr577 | YMEDSTYyKASKGKL | phosphorylation up-regulates | 23716717 | SIGNOR-202139 |
| PTK2 | PTK2 | Tyr577 | YMEDSTYyKASKGKL | phosphorylation up-regulates | 15694384 | SIGNOR-133845 |
| MET | PTK2 | Tyr577 | YMEDSTYyKASKGKL | phosphorylation up-regulates | 16782899 | SIGNOR-147195 |
| PTPN11 | PTK2 | Tyr577 | YMEDSTYyKASKGKL | dephosphorylation down-regulates | 16920701 | SIGNOR-148926 |
| RET | PTK2 | Tyr577 | YMEDSTYyKASKGKL | phosphorylation up-regulates | 21454698 | SIGNOR-173017 |
| SRC | PTK2 | Tyr577 | YMEDSTYyKASKGKL | phosphorylation up-regulates | 15735019 | SIGNOR-134212 |
| PTPRG | PTK2 | Tyr577 | YMEDSTYyKASKGKL | dephosphorylation down-regulates activity | 25624455 | SIGNOR-254718 |
| PTK2 | PTK2 | Tyr577 | YMEDSTYyKASKGKL | phosphorylation up-regulates | 7529876 | SIGNOR-27879 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| INSR | phosphorylation up-regulates → | PTK2 PTyr577 | phosphorylation up-regulates → | PTK2 | 9507031 | SIGNOR-251324 |
| FER | phosphorylation up-regulates → | PTK2 PTyr577 | phosphorylation up-regulates → | PTK2 | 19339212 | SIGNOR-279409 |
| BMX | phosphorylation up-regulates → | PTK2 PTyr577 | phosphorylation up-regulates → | PTK2 | 23716717 | SIGNOR-202139 |
| PTK2 | phosphorylation up-regulates → | PTK2 PTyr577 | phosphorylation up-regulates → | PTK2 | 15694384 | SIGNOR-133845 |
| MET | phosphorylation up-regulates → | PTK2 PTyr577 | phosphorylation up-regulates → | PTK2 | 16782899 | SIGNOR-147195 |
| PTPN11 | dephosphorylation down-regulates ⊣ | PTK2 PTyr577 | dephosphorylation up-regulates → | PTK2 | 16920701 | SIGNOR-148926 |
| RET | phosphorylation up-regulates → | PTK2 PTyr577 | phosphorylation up-regulates → | PTK2 | 21454698 | SIGNOR-173017 |
| SRC | phosphorylation up-regulates → | PTK2 PTyr577 | phosphorylation up-regulates → | PTK2 | 15735019 | SIGNOR-134212 |
| PTPRG | dephosphorylation down-regulates ⊣ | PTK2 PTyr577 | dephosphorylation up-regulates → | PTK2 | 25624455 | SIGNOR-254718 |
| PTK2 | phosphorylation up-regulates → | PTK2 PTyr577 | phosphorylation up-regulates → | PTK2 | 7529876 | SIGNOR-27879 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| INSR | phosphorylation → up-regulates activity | PTK2 | SIGNOR-251324 |
| FER | phosphorylation → up-regulates activity | PTK2 | SIGNOR-279409 |
| BMX | phosphorylation → up-regulates | PTK2 | SIGNOR-202139 |
| PTK2 | phosphorylation → up-regulates | PTK2 | SIGNOR-133845 |
| MET | phosphorylation → up-regulates | PTK2 | SIGNOR-147195 |
| PTPN11 | dephosphorylation down-regulates | PTK2 | SIGNOR-148926 |
| RET | phosphorylation → up-regulates | PTK2 | SIGNOR-173017 |
| SRC | phosphorylation → up-regulates | PTK2 | SIGNOR-134212 |
| PTPRG | dephosphorylation → down-regulates activity | PTK2 | SIGNOR-254718 |
| PTK2 | phosphorylation → up-regulates | PTK2 | SIGNOR-27879 |
