Entity Details

Name EEF1A2
ID Q05639
Role substrate
Enzymatic Domains
tr-type G 5-242
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
MAPK8EEF1A2Ser205GDNMLEPsPNMPWFKphosphorylation
down-regulates quantity by destabilization		23608534SIGNOR-276491
BRAFEEF1A2Ser21GHVDSGKsTTTGHLIphosphorylation
down-regulates quantity by destabilization		22378069SIGNOR-276406
RAF1EEF1A2Ser21GHVDSGKsTTTGHLIphosphorylation
down-regulates quantity by destabilization		22378069SIGNOR-276407
PRKCBEEF1A2Ser53AAEMGKGsFKYAWVLphosphorylation
up-regulates activity		20923971SIGNOR-263166
MAPK8EEF1A2Ser358GQISAGYsPVIDCHTphosphorylation
down-regulates quantity by destabilization		23608534SIGNOR-276492
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
MAPK8phosphorylation
up-regulates
→
EEF1A2
PSer205		phosphorylation
down-regulates
⊣		EEF1A223608534SIGNOR-276491
BRAFphosphorylation
up-regulates
→
EEF1A2
PSer21		phosphorylation
down-regulates
⊣		EEF1A222378069SIGNOR-276406
RAF1phosphorylation
up-regulates
→
EEF1A2
PSer21		phosphorylation
down-regulates
⊣		EEF1A222378069SIGNOR-276407
PRKCBphosphorylation
up-regulates
→
EEF1A2
PSer53		phosphorylation
up-regulates
→		EEF1A220923971SIGNOR-263166
MAPK8phosphorylation
up-regulates
→
EEF1A2
PSer358		phosphorylation
down-regulates
⊣		EEF1A223608534SIGNOR-276492
Regulator Mechanism/Effect Target SIGNOR-ID
MAPK8phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		EEF1A2SIGNOR-276491
BRAFphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		EEF1A2SIGNOR-276406
RAF1phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		EEF1A2SIGNOR-276407
PRKCBphosphorylation
→
up-regulates activity 		EEF1A2SIGNOR-263166
MAPK8phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		EEF1A2SIGNOR-276492