| Name | BTK |
| ID | Q06187 |
| Role | kinase |
| Enzymatic Domains |
PH 3-133 PROSITE-ProRule
SH3 214-274 PROSITE-ProRule
SH2 281-377 PROSITE-ProRule
Protein kinase 402-655 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| BTK | WIPF1 | Tyr468 | DLPPPEPyVQTTKSY | phosphorylation up-regulates activity | 25413351 | SIGNOR-279801 |
| BTK | PLCG2 | Tyr753 | ERDINSLyDVSRMYV | phosphorylation up-regulates | 11606584 | SIGNOR-111069 |
| BTK | PLCG2 | Tyr759 | LYDVSRMyVDPSEIN | phosphorylation up-regulates | 11606584 | SIGNOR-111073 |
| BTK | PLCG2 | Tyr1197 | LESEEELySSCRQLR | phosphorylation up-regulates activity | 11507089 | SIGNOR-109746 |
| BTK | PLCG2 | Tyr1217 | LNNQLFLyDTHQNLR | phosphorylation up-regulates activity | 11507089 | SIGNOR-109750 |
| BTK | PLCG2 | Tyr753 | ERDINSLyDVSRMYV | phosphorylation up-regulates activity | 11507089 | SIGNOR-109754 |
| BTK | PLCG2 | Tyr759 | LYDVSRMyVDPSEIN | phosphorylation up-regulates activity | 11507089 | SIGNOR-109758 |
| BTK | PLCG1 | – | phosphorylation up-regulates activity | 31431692 | SIGNOR-279444 | |
| BTK | STAT3 | – | phosphorylation down-regulates activity | 9751072 | SIGNOR-279011 | |
| BTK | STAT5A | Tyr694 | LAKAVDGyVKPQIKQ | phosphorylation up-regulates activity | 11413148 | SIGNOR-250603 |
| BTK | TEC | Tyr206 | RLERGQEyLILEKND | phosphorylation up-regulates | 12573241 | SIGNOR-98086 |
| BTK | WAS | Tyr291 | AETSKLIyDFIEDQG | phosphorylation unknown | 10068673 | SIGNOR-86004 |
| BTK | WAS | Tyr291 | AETSKLIyDFIEDQG | phosphorylation up-regulates activity | 10068673 | SIGNOR-273958 |
| BTK | BMX | Tyr216 | SSTSLAQyDSNSKKI | phosphorylation up-regulates | 12573241 | SIGNOR-98028 |
| BTK | BMX | Tyr224 | DSNSKKIyGSQPNFN | phosphorylation up-regulates | 12573241 | SIGNOR-98032 |
| BTK | GTF2I | – | phosphorylation up-regulates | 9012831 | SIGNOR-46060 | |
| BTK | GTF2I | Tyr248 | EESEDPDyYQYNIQA | phosphorylation up-regulates activity | 11373296 | SIGNOR-108338 |
| BTK | GTF2I | Tyr398 | QSHVEDLyVEGLPEG | phosphorylation up-regulates activity | 11373296 | SIGNOR-108342 |
| BTK | GTF2I | Tyr503 | EAHPNDLyVEGLPEN | phosphorylation up-regulates activity | 11373296 | SIGNOR-108346 |
| BTK | MDM2 | – | phosphorylation down-regulates activity | 29290977 | SIGNOR-278330 | |
| BTK | RELA | – | phosphorylation up-regulates activity | 26018652 | SIGNOR-280197 | |
| BTK | BTK | Tyr551 | RYVLDDEyTSSVGSK | phosphorylation up-regulates | 8630736 | SIGNOR-41480 |
| BTK | ITK | Tyr180 | ETVVIALyDYQTNDP | phosphorylation up-regulates | 12573241 | SIGNOR-98036 |
| BTK | IKZF1 | Ser214 | GRSYKQRsSLEEHKE | phosphorylation up-regulates activity | 23977012 | SIGNOR-279443 |
| BTK | IKZF1 | Ser215 | RSYKQRSsLEEHKER | phosphorylation up-regulates activity | 23977012 | SIGNOR-279442 |
| BTK | CNN3 | – | phosphorylation up-regulates quantity | 26046660 | SIGNOR-280196 | |
| BTK | DDX41 | Tyr414 | DVIQEVEyVKEEAKM | phosphorylation up-regulates activity | 25704810 | SIGNOR-266404 |
| BTK | DAPP1 | Tyr139 | KVEEPSIyESVRVHT | phosphorylation up-regulates activity | 10880360 | SIGNOR-249313 |
| BTK | DAPP1 | Tyr139 | KVEEPSIyESVRVHT | phosphorylation up-regulates activity | 11524430 | SIGNOR-250602 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| BTK | phosphorylation up-regulates → | WIPF1 PTyr468 | phosphorylation up-regulates → | WIPF1 | 25413351 | SIGNOR-279801 |
| BTK | phosphorylation up-regulates → | PLCG2 PTyr753 | phosphorylation up-regulates → | PLCG2 | 11606584 | SIGNOR-111069 |
| BTK | phosphorylation up-regulates → | PLCG2 PTyr759 | phosphorylation up-regulates → | PLCG2 | 11606584 | SIGNOR-111073 |
| BTK | phosphorylation up-regulates → | PLCG2 PTyr1197 | phosphorylation up-regulates → | PLCG2 | 11507089 | SIGNOR-109746 |
| BTK | phosphorylation up-regulates → | PLCG2 PTyr1217 | phosphorylation up-regulates → | PLCG2 | 11507089 | SIGNOR-109750 |
| BTK | phosphorylation up-regulates → | PLCG2 PTyr753 | phosphorylation up-regulates → | PLCG2 | 11507089 | SIGNOR-109754 |
| BTK | phosphorylation up-regulates → | PLCG2 PTyr759 | phosphorylation up-regulates → | PLCG2 | 11507089 | SIGNOR-109758 |
| BTK | phosphorylation up-regulates → | STAT5A PTyr694 | phosphorylation up-regulates → | STAT5A | 11413148 | SIGNOR-250603 |
| BTK | phosphorylation up-regulates → | TEC PTyr206 | phosphorylation up-regulates → | TEC | 12573241 | SIGNOR-98086 |
| BTK | phosphorylation up-regulates → | WAS PTyr291 | phosphorylation down-regulates ⊣ | WAS | 10068673 | SIGNOR-86004 |
| BTK | phosphorylation up-regulates → | WAS PTyr291 | phosphorylation up-regulates → | WAS | 10068673 | SIGNOR-273958 |
| BTK | phosphorylation up-regulates → | BMX PTyr216 | phosphorylation up-regulates → | BMX | 12573241 | SIGNOR-98028 |
| BTK | phosphorylation up-regulates → | BMX PTyr224 | phosphorylation up-regulates → | BMX | 12573241 | SIGNOR-98032 |
| BTK | phosphorylation up-regulates → | GTF2I PTyr248 | phosphorylation up-regulates → | GTF2I | 11373296 | SIGNOR-108338 |
| BTK | phosphorylation up-regulates → | GTF2I PTyr398 | phosphorylation up-regulates → | GTF2I | 11373296 | SIGNOR-108342 |
| BTK | phosphorylation up-regulates → | GTF2I PTyr503 | phosphorylation up-regulates → | GTF2I | 11373296 | SIGNOR-108346 |
| BTK | phosphorylation up-regulates → | BTK PTyr551 | phosphorylation up-regulates → | BTK | 8630736 | SIGNOR-41480 |
| BTK | phosphorylation up-regulates → | ITK PTyr180 | phosphorylation up-regulates → | ITK | 12573241 | SIGNOR-98036 |
| BTK | phosphorylation up-regulates → | IKZF1 PSer214 | phosphorylation up-regulates → | IKZF1 | 23977012 | SIGNOR-279443 |
| BTK | phosphorylation up-regulates → | IKZF1 PSer215 | phosphorylation up-regulates → | IKZF1 | 23977012 | SIGNOR-279442 |
| BTK | phosphorylation up-regulates → | DDX41 PTyr414 | phosphorylation up-regulates → | DDX41 | 25704810 | SIGNOR-266404 |
| BTK | phosphorylation up-regulates → | DAPP1 PTyr139 | phosphorylation up-regulates → | DAPP1 | 10880360 | SIGNOR-249313 |
| BTK | phosphorylation up-regulates → | DAPP1 PTyr139 | phosphorylation up-regulates → | DAPP1 | 11524430 | SIGNOR-250602 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| BTK | phosphorylation → up-regulates activity | WIPF1 | SIGNOR-279801 |
| BTK | phosphorylation → up-regulates | PLCG2 | SIGNOR-111069 |
| BTK | phosphorylation → up-regulates | PLCG2 | SIGNOR-111073 |
| BTK | phosphorylation → up-regulates activity | PLCG2 | SIGNOR-109746 |
| BTK | phosphorylation → up-regulates activity | PLCG2 | SIGNOR-109750 |
| BTK | phosphorylation → up-regulates activity | PLCG2 | SIGNOR-109754 |
| BTK | phosphorylation → up-regulates activity | PLCG2 | SIGNOR-109758 |
| BTK | phosphorylation → up-regulates activity | PLCG1 | SIGNOR-279444 |
| BTK | phosphorylation → down-regulates activity | STAT3 | SIGNOR-279011 |
| BTK | phosphorylation → up-regulates activity | STAT5A | SIGNOR-250603 |
| BTK | phosphorylation → up-regulates | TEC | SIGNOR-98086 |
| BTK | phosphorylation → unknown | WAS | SIGNOR-86004 |
| BTK | phosphorylation → up-regulates activity | WAS | SIGNOR-273958 |
| BTK | phosphorylation → up-regulates | BMX | SIGNOR-98028 |
| BTK | phosphorylation → up-regulates | BMX | SIGNOR-98032 |
| BTK | phosphorylation → up-regulates | GTF2I | SIGNOR-46060 |
| BTK | phosphorylation → up-regulates activity | GTF2I | SIGNOR-108338 |
| BTK | phosphorylation → up-regulates activity | GTF2I | SIGNOR-108342 |
| BTK | phosphorylation → up-regulates activity | GTF2I | SIGNOR-108346 |
| BTK | phosphorylation → down-regulates activity | MDM2 | SIGNOR-278330 |
| BTK | phosphorylation → up-regulates activity | RELA | SIGNOR-280197 |
| BTK | phosphorylation → up-regulates | BTK | SIGNOR-41480 |
| BTK | phosphorylation → up-regulates | ITK | SIGNOR-98036 |
| BTK | phosphorylation → up-regulates activity | IKZF1 | SIGNOR-279443 |
| BTK | phosphorylation → up-regulates activity | IKZF1 | SIGNOR-279442 |
| BTK | phosphorylation → up-regulates quantity | CNN3 | SIGNOR-280196 |
| BTK | phosphorylation → up-regulates activity | DDX41 | SIGNOR-266404 |
| BTK | phosphorylation → up-regulates activity | DAPP1 | SIGNOR-249313 |
| BTK | phosphorylation → up-regulates activity | DAPP1 | SIGNOR-250602 |