| Name | BTK |
| ID | Q06187 |
| Role | substrate |
| Enzymatic Domains |
PH 3-133 PROSITE-ProRule
SH3 214-274 PROSITE-ProRule
SH2 281-377 PROSITE-ProRule
Protein kinase 402-655 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPRG | BTK | Tyr223 | LKKVVALyDYMPMNA | dephosphorylation down-regulates activity | 25624455 | SIGNOR-254694 |
| TEC | BTK | Tyr223 | LKKVVALyDYMPMNA | phosphorylation down-regulates activity | 12573241 | SIGNOR-246652 |
| PIK3CA | BTK | – | phosphorylation up-regulates activity | 10201980 | SIGNOR-249610 | |
| PRKCB | BTK | Ser180 | GSLKPGSsHRKTKKP | phosphorylation down-regulates activity | 11598012 | SIGNOR-249110 |
| ABL1 | BTK | Tyr223 | LKKVVALyDYMPMNA | phosphorylation down-regulates activity | 12445832 | SIGNOR-260801 |
| ITK | BTK | Tyr223 | LKKVVALyDYMPMNA | phosphorylation down-regulates activity | 12573241 | SIGNOR-251333 |
| LYN | BTK | Tyr551 | RYVLDDEyTSSVGSK | phosphorylation up-regulates | 8630736 | SIGNOR-41607 |
| PI3K | BTK | – | phosphorylation up-regulates activity | 10201980 | SIGNOR-252709 | |
| ABL1 | BTK | Tyr223 | LKKVVALyDYMPMNA | phosphorylation unknown | 12445832 | SIGNOR-245278 |
| AKT1 | BTK | Ser51 | FERGRRGsKKGSIDV | phosphorylation down-regulates quantity by destabilization | 23754751 | SIGNOR-276466 |
| SRC | BTK | Tyr551 | RYVLDDEyTSSVGSK | phosphorylation up-regulates activity | 8629002 | SIGNOR-251100 |
| BTK | BTK | Tyr551 | RYVLDDEyTSSVGSK | phosphorylation up-regulates | 8630736 | SIGNOR-41480 |
| JAK2 | BTK | – | phosphorylation up-regulates activity | 15007095 | SIGNOR-279196 | |
| SYK | BTK | Tyr551 | RYVLDDEyTSSVGSK | phosphorylation up-regulates activity | 11226282 | SIGNOR-247586 |
| AKT1 | BTK | Thr495 | EMRHRFQtQQLLEMC | phosphorylation down-regulates quantity by destabilization | 23754751 | SIGNOR-276465 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPRG | dephosphorylation down-regulates ⊣ | BTK PTyr223 | dephosphorylation up-regulates → | BTK | 25624455 | SIGNOR-254694 |
| TEC | phosphorylation up-regulates → | BTK PTyr223 | phosphorylation down-regulates ⊣ | BTK | 12573241 | SIGNOR-246652 |
| PRKCB | phosphorylation up-regulates → | BTK PSer180 | phosphorylation down-regulates ⊣ | BTK | 11598012 | SIGNOR-249110 |
| ABL1 | phosphorylation up-regulates → | BTK PTyr223 | phosphorylation down-regulates ⊣ | BTK | 12445832 | SIGNOR-260801 |
| ITK | phosphorylation up-regulates → | BTK PTyr223 | phosphorylation down-regulates ⊣ | BTK | 12573241 | SIGNOR-251333 |
| LYN | phosphorylation up-regulates → | BTK PTyr551 | phosphorylation up-regulates → | BTK | 8630736 | SIGNOR-41607 |
| ABL1 | phosphorylation up-regulates → | BTK PTyr223 | phosphorylation down-regulates ⊣ | BTK | 12445832 | SIGNOR-245278 |
| AKT1 | phosphorylation up-regulates → | BTK PSer51 | phosphorylation down-regulates ⊣ | BTK | 23754751 | SIGNOR-276466 |
| SRC | phosphorylation up-regulates → | BTK PTyr551 | phosphorylation up-regulates → | BTK | 8629002 | SIGNOR-251100 |
| BTK | phosphorylation up-regulates → | BTK PTyr551 | phosphorylation up-regulates → | BTK | 8630736 | SIGNOR-41480 |
| SYK | phosphorylation up-regulates → | BTK PTyr551 | phosphorylation up-regulates → | BTK | 11226282 | SIGNOR-247586 |
| AKT1 | phosphorylation up-regulates → | BTK PThr495 | phosphorylation down-regulates ⊣ | BTK | 23754751 | SIGNOR-276465 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPRG | dephosphorylation → down-regulates activity | BTK | SIGNOR-254694 |
| TEC | phosphorylation → down-regulates activity | BTK | SIGNOR-246652 |
| PIK3CA | phosphorylation → up-regulates activity | BTK | SIGNOR-249610 |
| PRKCB | phosphorylation → down-regulates activity | BTK | SIGNOR-249110 |
| ABL1 | phosphorylation → down-regulates activity | BTK | SIGNOR-260801 |
| ITK | phosphorylation → down-regulates activity | BTK | SIGNOR-251333 |
| LYN | phosphorylation → up-regulates | BTK | SIGNOR-41607 |
| PI3K | phosphorylation → up-regulates activity | BTK | SIGNOR-252709 |
| ABL1 | phosphorylation → unknown | BTK | SIGNOR-245278 |
| AKT1 | phosphorylation down-regulates quantity by destabilization | BTK | SIGNOR-276466 |
| SRC | phosphorylation → up-regulates activity | BTK | SIGNOR-251100 |
| BTK | phosphorylation → up-regulates | BTK | SIGNOR-41480 |
| JAK2 | phosphorylation → up-regulates activity | BTK | SIGNOR-279196 |
| SYK | phosphorylation → up-regulates activity | BTK | SIGNOR-247586 |
| AKT1 | phosphorylation down-regulates quantity by destabilization | BTK | SIGNOR-276465 |