| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| SYK | BTK | Tyr551 | RYVLDDEyTSSVGSK | phosphorylation up-regulates activity | 11226282 | SIGNOR-247586 |
| LYN | BTK | Tyr551 | RYVLDDEyTSSVGSK | phosphorylation up-regulates | 8630736 | SIGNOR-41607 |
| SRC | BTK | Tyr551 | RYVLDDEyTSSVGSK | phosphorylation up-regulates activity | 8629002 | SIGNOR-251100 |
| BTK | BTK | Tyr551 | RYVLDDEyTSSVGSK | phosphorylation up-regulates | 8630736 | SIGNOR-41480 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| SYK | phosphorylation up-regulates → | BTK PTyr551 | phosphorylation up-regulates → | BTK | 11226282 | SIGNOR-247586 |
| LYN | phosphorylation up-regulates → | BTK PTyr551 | phosphorylation up-regulates → | BTK | 8630736 | SIGNOR-41607 |
| SRC | phosphorylation up-regulates → | BTK PTyr551 | phosphorylation up-regulates → | BTK | 8629002 | SIGNOR-251100 |
| BTK | phosphorylation up-regulates → | BTK PTyr551 | phosphorylation up-regulates → | BTK | 8630736 | SIGNOR-41480 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| SYK | phosphorylation → up-regulates activity | BTK | SIGNOR-247586 |
| LYN | phosphorylation → up-regulates | BTK | SIGNOR-41607 |
| SRC | phosphorylation → up-regulates activity | BTK | SIGNOR-251100 |
| BTK | phosphorylation → up-regulates | BTK | SIGNOR-41480 |