| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ABL1 | BTK | Tyr223 | LKKVVALyDYMPMNA | phosphorylation down-regulates activity | 12445832 | SIGNOR-260801 |
| ITK | BTK | Tyr223 | LKKVVALyDYMPMNA | phosphorylation down-regulates activity | 12573241 | SIGNOR-251333 |
| ABL1 | BTK | Tyr223 | LKKVVALyDYMPMNA | phosphorylation unknown | 12445832 | SIGNOR-245278 |
| PTPRG | BTK | Tyr223 | LKKVVALyDYMPMNA | dephosphorylation down-regulates activity | 25624455 | SIGNOR-254694 |
| TEC | BTK | Tyr223 | LKKVVALyDYMPMNA | phosphorylation down-regulates activity | 12573241 | SIGNOR-246652 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ABL1 | phosphorylation up-regulates → | BTK PTyr223 | phosphorylation down-regulates ⊣ | BTK | 12445832 | SIGNOR-260801 |
| ITK | phosphorylation up-regulates → | BTK PTyr223 | phosphorylation down-regulates ⊣ | BTK | 12573241 | SIGNOR-251333 |
| ABL1 | phosphorylation up-regulates → | BTK PTyr223 | phosphorylation down-regulates ⊣ | BTK | 12445832 | SIGNOR-245278 |
| PTPRG | dephosphorylation down-regulates ⊣ | BTK PTyr223 | dephosphorylation up-regulates → | BTK | 25624455 | SIGNOR-254694 |
| TEC | phosphorylation up-regulates → | BTK PTyr223 | phosphorylation down-regulates ⊣ | BTK | 12573241 | SIGNOR-246652 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| ABL1 | phosphorylation → down-regulates activity | BTK | SIGNOR-260801 |
| ITK | phosphorylation → down-regulates activity | BTK | SIGNOR-251333 |
| ABL1 | phosphorylation → unknown | BTK | SIGNOR-245278 |
| PTPRG | dephosphorylation → down-regulates activity | BTK | SIGNOR-254694 |
| TEC | phosphorylation → down-regulates activity | BTK | SIGNOR-246652 |
