| Name | MEF2C |
| ID | Q06413 |
| Role | substrate |
| Enzymatic Domains |
MADS-box 3-57 PROSITE-ProRule |
View in  |
|
| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK14 | MEF2C | – | phosphorylation up-regulates activity | 21902831 | SIGNOR-176551 | |
| MYLK3 | MEF2C | Thr80 | NEPHESRtNSDIVET | phosphorylation up-regulates activity | 21556048 | SIGNOR-264565 |
| CSNK2A1 | MEF2C | Ser59 | NKLFQYAsTDMDKVL | phosphorylation up-regulates activity | 8663403 | SIGNOR-250914 |
| MAPK14 | MEF2C | Thr300 | TPVVSVAtPTLPGQG | phosphorylation up-regulates activity | 9858528 | SIGNOR-62796 |
| MAPK14 | MEF2C | Ser387 | LSLPSTQsLNIKSEP | phosphorylation up-regulates activity | 9858528 | SIGNOR-62788 |
| MYLK2 | MEF2C | Thr80 | NEPHESRtNSDIVET | phosphorylation up-regulates activity | 21556048 | SIGNOR-238118 |
| MAPK11 | MEF2C | – | phosphorylation up-regulates activity | 10330143 | SIGNOR-280025 | |
| CyclinB/CDK1 | MEF2C | Ser396 | NIKSEPVsPPRDRTT | phosphorylation down-regulates activity | 16478538 | SIGNOR-250719 |
| HIPK2 | MEF2C | – | phosphorylation down-regulates activity | 23620283 | SIGNOR-279192 | |
| MAPK14 | MEF2C | Thr293 | QSAQSLAtPVVSVAT | phosphorylation up-regulates activity | 9858528 | SIGNOR-62792 |
| MAPK7 | MEF2C | Ser387 | LSLPSTQsLNIKSEP | phosphorylation up-regulates | 9384584 | SIGNOR-53545 |
| MAPK14 | MEF2C | Thr293 | QSAQSLAtPVVSVAT | phosphorylation up-regulates activity | 9069290 | SIGNOR-47136 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MYLK3 | phosphorylation up-regulates → | MEF2C PThr80 | phosphorylation up-regulates → | MEF2C | 21556048 | SIGNOR-264565 |
| CSNK2A1 | phosphorylation up-regulates → | MEF2C PSer59 | phosphorylation up-regulates → | MEF2C | 8663403 | SIGNOR-250914 |
| MAPK14 | phosphorylation up-regulates → | MEF2C PThr300 | phosphorylation up-regulates → | MEF2C | 9858528 | SIGNOR-62796 |
| MAPK14 | phosphorylation up-regulates → | MEF2C PSer387 | phosphorylation up-regulates → | MEF2C | 9858528 | SIGNOR-62788 |
| MYLK2 | phosphorylation up-regulates → | MEF2C PThr80 | phosphorylation up-regulates → | MEF2C | 21556048 | SIGNOR-238118 |
| CyclinB/CDK1 | phosphorylation up-regulates → | MEF2C PSer396 | phosphorylation down-regulates ⊣ | MEF2C | 16478538 | SIGNOR-250719 |
| MAPK14 | phosphorylation up-regulates → | MEF2C PThr293 | phosphorylation up-regulates → | MEF2C | 9858528 | SIGNOR-62792 |
| MAPK7 | phosphorylation up-regulates → | MEF2C PSer387 | phosphorylation up-regulates → | MEF2C | 9384584 | SIGNOR-53545 |
| MAPK14 | phosphorylation up-regulates → | MEF2C PThr293 | phosphorylation up-regulates → | MEF2C | 9069290 | SIGNOR-47136 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK14 | phosphorylation → up-regulates activity | MEF2C | SIGNOR-176551 |
| MYLK3 | phosphorylation → up-regulates activity | MEF2C | SIGNOR-264565 |
| CSNK2A1 | phosphorylation → up-regulates activity | MEF2C | SIGNOR-250914 |
| MAPK14 | phosphorylation → up-regulates activity | MEF2C | SIGNOR-62796 |
| MAPK14 | phosphorylation → up-regulates activity | MEF2C | SIGNOR-62788 |
| MYLK2 | phosphorylation → up-regulates activity | MEF2C | SIGNOR-238118 |
| MAPK11 | phosphorylation → up-regulates activity | MEF2C | SIGNOR-280025 |
| CyclinB/CDK1 | phosphorylation → down-regulates activity | MEF2C | SIGNOR-250719 |
| HIPK2 | phosphorylation → down-regulates activity | MEF2C | SIGNOR-279192 |
| MAPK14 | phosphorylation → up-regulates activity | MEF2C | SIGNOR-62792 |
| MAPK7 | phosphorylation → up-regulates | MEF2C | SIGNOR-53545 |
| MAPK14 | phosphorylation → up-regulates activity | MEF2C | SIGNOR-47136 |