Entity Details

Name TYRO3
ID Q06418
Role kinase
Enzymatic Domains
Ig-like C2-type 1 41-128
Ig-like C2-type 2 139-220
Fibronectin type-III 1 227-320
PROSITE-ProRule
Fibronectin type-III 2 325-416
PROSITE-ProRule
Protein kinase 518-790
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
TYRO3FOXO3–phosphorylation
down-regulates activity		21291561SIGNOR-279669
TYRO3CBLBTyr133KEGKERMyEEQSQDRphosphorylation
up-regulates activity		31531847SIGNOR-279576
TYRO3CBLBTyr363TQEQYELyCEMGSTFphosphorylation
up-regulates activity		31531847SIGNOR-279577
TYRO3MLKLTyr376DRVKSTAyLSPQELEphosphorylation
up-regulates quantity by stabilization		31230815SIGNOR-274120
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
TYRO3phosphorylation
up-regulates
→
CBLB
PTyr133		phosphorylation
up-regulates
→		CBLB31531847SIGNOR-279576
TYRO3phosphorylation
up-regulates
→
CBLB
PTyr363		phosphorylation
up-regulates
→		CBLB31531847SIGNOR-279577
TYRO3phosphorylation
up-regulates
→
MLKL
PTyr376		phosphorylation
up-regulates
→		MLKL31230815SIGNOR-274120
Regulator Mechanism/Effect Target SIGNOR-ID
TYRO3phosphorylation
→
down-regulates activity 		FOXO3SIGNOR-279669
TYRO3phosphorylation
→
up-regulates activity 		CBLBSIGNOR-279576
TYRO3phosphorylation
→
up-regulates activity 		CBLBSIGNOR-279577
TYRO3phosphorylation
→
up-regulates quantity by stabilization 		MLKLSIGNOR-274120