| Name | APLP2 |
| ID | Q06481 |
| Role | substrate |
| Enzymatic Domains |
E1 46-205 PROSITE-ProRule
BPTI/Kunitz inhibitor 306-364 PROSITE-ProRule
E2 373-564 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK8 | APLP2 | Thr736 | VEVDPMLtPEERHLN | phosphorylation up-regulates | 14970211 | SIGNOR-122196 |
| CDK1 | APLP2 | Thr736 | VEVDPMLtPEERHLN | phosphorylation unknown | 9109675 | SIGNOR-47483 |
| PRKCA | APLP2 | Thr723 | LRKRQYGtISHGIVE | phosphorylation unknown | 9109675 | SIGNOR-248970 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK8 | phosphorylation up-regulates → | APLP2 PThr736 | phosphorylation up-regulates → | APLP2 | 14970211 | SIGNOR-122196 |
| CDK1 | phosphorylation up-regulates → | APLP2 PThr736 | phosphorylation down-regulates ⊣ | APLP2 | 9109675 | SIGNOR-47483 |
| PRKCA | phosphorylation up-regulates → | APLP2 PThr723 | phosphorylation down-regulates ⊣ | APLP2 | 9109675 | SIGNOR-248970 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK8 | phosphorylation → up-regulates | APLP2 | SIGNOR-122196 |
| CDK1 | phosphorylation → unknown | APLP2 | SIGNOR-47483 |
| PRKCA | phosphorylation → unknown | APLP2 | SIGNOR-248970 |