| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK2 | RAD51 | – | phosphorylation down-regulates quantity by destabilization | 25927241 | SIGNOR-280213 | |
| CHEK1 | RAD51 | Thr309 | LRKGRGEtRICKIYD | phosphorylation up-regulates | 15665856 | SIGNOR-133375 |
| ABL1 | RAD51 | Tyr54 | HTVEAVAyAPKKELI | phosphorylation down-regulates | 9461559 | SIGNOR-55482 |
| ABL1 | RAD51 | Tyr315 | ETRICKIyDSPCLPE | phosphorylation up-regulates activity | 10212258 | SIGNOR-251434 |
| ABL1 | RAD51 | – | phosphorylation up-regulates | 10212258 | SIGNOR-67069 | |
| PLK1 | RAD51 | Ser14 | LEANADTsVEEESFG | phosphorylation up-regulates activity | 26811421 | SIGNOR-278187 |
| BCR-ABL | RAD51 | Tyr315 | ETRICKIyDSPCLPE | phosphorylation up-regulates activity | 11684015 | SIGNOR-271707 |
| ABL1 | RAD51 | Tyr315 | ETRICKIyDSPCLPE | phosphorylation up-regulates activity | 10212258 | SIGNOR-247594 |
| ABL1 | RAD51 | Tyr315 | ETRICKIyDSPCLPE | phosphorylation up-regulates activity | 10212258 | SIGNOR-260777 |
| ABL1 | RAD51 | Tyr315 | ETRICKIyDSPCLPE | phosphorylation up-regulates activity | 11684015 | SIGNOR-247599 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CHEK1 | phosphorylation up-regulates → | RAD51 PThr309 | phosphorylation up-regulates → | RAD51 | 15665856 | SIGNOR-133375 |
| ABL1 | phosphorylation up-regulates → | RAD51 PTyr54 | phosphorylation down-regulates ⊣ | RAD51 | 9461559 | SIGNOR-55482 |
| ABL1 | phosphorylation up-regulates → | RAD51 PTyr315 | phosphorylation up-regulates → | RAD51 | 10212258 | SIGNOR-251434 |
| PLK1 | phosphorylation up-regulates → | RAD51 PSer14 | phosphorylation up-regulates → | RAD51 | 26811421 | SIGNOR-278187 |
| BCR-ABL | phosphorylation up-regulates → | RAD51 PTyr315 | phosphorylation up-regulates → | RAD51 | 11684015 | SIGNOR-271707 |
| ABL1 | phosphorylation up-regulates → | RAD51 PTyr315 | phosphorylation up-regulates → | RAD51 | 10212258 | SIGNOR-247594 |
| ABL1 | phosphorylation up-regulates → | RAD51 PTyr315 | phosphorylation up-regulates → | RAD51 | 10212258 | SIGNOR-260777 |
| ABL1 | phosphorylation up-regulates → | RAD51 PTyr315 | phosphorylation up-regulates → | RAD51 | 11684015 | SIGNOR-247599 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDK2 | phosphorylation down-regulates quantity by destabilization | RAD51 | SIGNOR-280213 |
| CHEK1 | phosphorylation → up-regulates | RAD51 | SIGNOR-133375 |
| ABL1 | phosphorylation down-regulates | RAD51 | SIGNOR-55482 |
| ABL1 | phosphorylation → up-regulates activity | RAD51 | SIGNOR-251434 |
| ABL1 | phosphorylation → up-regulates | RAD51 | SIGNOR-67069 |
| PLK1 | phosphorylation → up-regulates activity | RAD51 | SIGNOR-278187 |
| BCR-ABL | phosphorylation → up-regulates activity | RAD51 | SIGNOR-271707 |
| ABL1 | phosphorylation → up-regulates activity | RAD51 | SIGNOR-247594 |
| ABL1 | phosphorylation → up-regulates activity | RAD51 | SIGNOR-260777 |
| ABL1 | phosphorylation → up-regulates activity | RAD51 | SIGNOR-247599 |
