| Name | PRDX1 |
| ID | Q06830 |
| Role | substrate |
| Enzymatic Domains |
Thioredoxin 6-165 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PBK | PRDX1 | Ser32 | QFKDISLsDYKGKYV | phosphorylation up-regulates | 20647304 | SIGNOR-166901 |
| STK4 | PRDX1 | Thr90 | CHLAWVNtPKKQGGL | phosphorylation down-regulates activity | 23386615 | SIGNOR-276487 |
| CDK2 | PRDX1 | Thr90 | CHLAWVNtPKKQGGL | phosphorylation down-regulates | 11986303 | SIGNOR-87101 |
| CDK1 | PRDX1 | Thr90 | CHLAWVNtPKKQGGL | phosphorylation down-regulates | 11986303 | SIGNOR-87097 |
| CDK6 | PRDX1 | Thr90 | CHLAWVNtPKKQGGL | phosphorylation down-regulates | 11986303 | SIGNOR-87113 |
| STK4 | PRDX1 | Thr18 | PAPNFKAtAVMPDGQ | phosphorylation down-regulates activity | 23386615 | SIGNOR-276486 |
| STK4 | PRDX1 | Thr183 | GWKPGSDtIKPDVQK | phosphorylation down-regulates activity | 23386615 | SIGNOR-276485 |
| CDK4 | PRDX1 | Thr90 | CHLAWVNtPKKQGGL | phosphorylation down-regulates | 11986303 | SIGNOR-87105 |
| ABL1 | PRDX1 | Tyr194 | DVQKSKEyFSKQK | phosphorylation down-regulates activity | 20178744 | SIGNOR-276278 |
| LCK | PRDX1 | Tyr194 | DVQKSKEyFSKQK | phosphorylation down-regulates activity | 20178744 | SIGNOR-276277 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PBK | phosphorylation up-regulates → | PRDX1 PSer32 | phosphorylation up-regulates → | PRDX1 | 20647304 | SIGNOR-166901 |
| STK4 | phosphorylation up-regulates → | PRDX1 PThr90 | phosphorylation down-regulates ⊣ | PRDX1 | 23386615 | SIGNOR-276487 |
| CDK2 | phosphorylation up-regulates → | PRDX1 PThr90 | phosphorylation down-regulates ⊣ | PRDX1 | 11986303 | SIGNOR-87101 |
| CDK1 | phosphorylation up-regulates → | PRDX1 PThr90 | phosphorylation down-regulates ⊣ | PRDX1 | 11986303 | SIGNOR-87097 |
| CDK6 | phosphorylation up-regulates → | PRDX1 PThr90 | phosphorylation down-regulates ⊣ | PRDX1 | 11986303 | SIGNOR-87113 |
| STK4 | phosphorylation up-regulates → | PRDX1 PThr18 | phosphorylation down-regulates ⊣ | PRDX1 | 23386615 | SIGNOR-276486 |
| STK4 | phosphorylation up-regulates → | PRDX1 PThr183 | phosphorylation down-regulates ⊣ | PRDX1 | 23386615 | SIGNOR-276485 |
| CDK4 | phosphorylation up-regulates → | PRDX1 PThr90 | phosphorylation down-regulates ⊣ | PRDX1 | 11986303 | SIGNOR-87105 |
| ABL1 | phosphorylation up-regulates → | PRDX1 PTyr194 | phosphorylation down-regulates ⊣ | PRDX1 | 20178744 | SIGNOR-276278 |
| LCK | phosphorylation up-regulates → | PRDX1 PTyr194 | phosphorylation down-regulates ⊣ | PRDX1 | 20178744 | SIGNOR-276277 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PBK | phosphorylation → up-regulates | PRDX1 | SIGNOR-166901 |
| STK4 | phosphorylation → down-regulates activity | PRDX1 | SIGNOR-276487 |
| CDK2 | phosphorylation down-regulates | PRDX1 | SIGNOR-87101 |
| CDK1 | phosphorylation down-regulates | PRDX1 | SIGNOR-87097 |
| CDK6 | phosphorylation down-regulates | PRDX1 | SIGNOR-87113 |
| STK4 | phosphorylation → down-regulates activity | PRDX1 | SIGNOR-276486 |
| STK4 | phosphorylation → down-regulates activity | PRDX1 | SIGNOR-276485 |
| CDK4 | phosphorylation down-regulates | PRDX1 | SIGNOR-87105 |
| ABL1 | phosphorylation → down-regulates activity | PRDX1 | SIGNOR-276278 |
| LCK | phosphorylation → down-regulates activity | PRDX1 | SIGNOR-276277 |