| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| STK4 | PRDX1 | Thr90 | CHLAWVNtPKKQGGL | phosphorylation down-regulates activity | 23386615 | SIGNOR-276487 |
| CDK2 | PRDX1 | Thr90 | CHLAWVNtPKKQGGL | phosphorylation down-regulates | 11986303 | SIGNOR-87101 |
| CDK1 | PRDX1 | Thr90 | CHLAWVNtPKKQGGL | phosphorylation down-regulates | 11986303 | SIGNOR-87097 |
| CDK6 | PRDX1 | Thr90 | CHLAWVNtPKKQGGL | phosphorylation down-regulates | 11986303 | SIGNOR-87113 |
| CDK4 | PRDX1 | Thr90 | CHLAWVNtPKKQGGL | phosphorylation down-regulates | 11986303 | SIGNOR-87105 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| STK4 | phosphorylation up-regulates → | PRDX1 PThr90 | phosphorylation down-regulates ⊣ | PRDX1 | 23386615 | SIGNOR-276487 |
| CDK2 | phosphorylation up-regulates → | PRDX1 PThr90 | phosphorylation down-regulates ⊣ | PRDX1 | 11986303 | SIGNOR-87101 |
| CDK1 | phosphorylation up-regulates → | PRDX1 PThr90 | phosphorylation down-regulates ⊣ | PRDX1 | 11986303 | SIGNOR-87097 |
| CDK6 | phosphorylation up-regulates → | PRDX1 PThr90 | phosphorylation down-regulates ⊣ | PRDX1 | 11986303 | SIGNOR-87113 |
| CDK4 | phosphorylation up-regulates → | PRDX1 PThr90 | phosphorylation down-regulates ⊣ | PRDX1 | 11986303 | SIGNOR-87105 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| STK4 | phosphorylation → down-regulates activity | PRDX1 | SIGNOR-276487 |
| CDK2 | phosphorylation down-regulates | PRDX1 | SIGNOR-87101 |
| CDK1 | phosphorylation down-regulates | PRDX1 | SIGNOR-87097 |
| CDK6 | phosphorylation down-regulates | PRDX1 | SIGNOR-87113 |
| CDK4 | phosphorylation down-regulates | PRDX1 | SIGNOR-87105 |
