Entity Details

Name PDE4B
ID Q07343
Role substrate
Enzymatic Domains
PDEase 330-659
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
PRKACAPDE4BSer56NLQLPPLsQRQSERAphosphorylation
up-regulates activity		12441002SIGNOR-250024
PKAPDE4BSer133GHSQRREsFLYRSDSphosphorylation
up-regulates activity		12023945SIGNOR-273940
PKAPDE4BSer133GHSQRREsFLYRSDSphosphorylation
up-regulates activity		12023945SIGNOR-275986
MAPK1PDE4BSer659YQSMIPQsPSPPLDEphosphorylation
up-regulates activity		11030732SIGNOR-275970
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
PRKACAphosphorylation
up-regulates
→
PDE4B
PSer56		phosphorylation
up-regulates
→		PDE4B12441002SIGNOR-250024
PKAphosphorylation
up-regulates
→
PDE4B
PSer133		phosphorylation
up-regulates
→		PDE4B12023945SIGNOR-273940
PKAphosphorylation
up-regulates
→
PDE4B
PSer133		phosphorylation
up-regulates
→		PDE4B12023945SIGNOR-275986
MAPK1phosphorylation
up-regulates
→
PDE4B
PSer659		phosphorylation
up-regulates
→		PDE4B11030732SIGNOR-275970
Regulator Mechanism/Effect Target SIGNOR-ID
PRKACAphosphorylation
→
up-regulates activity 		PDE4BSIGNOR-250024
PKAphosphorylation
→
up-regulates activity 		PDE4BSIGNOR-273940
PKAphosphorylation
→
up-regulates activity 		PDE4BSIGNOR-275986
MAPK1phosphorylation
→
up-regulates activity 		PDE4BSIGNOR-275970