| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT | BAX | Ser184 | VAGVLTAsLTIWKKM | phosphorylation down-regulates activity | 14766748 | SIGNOR-209651 |
| AKT1 | BAX | Ser184 | VAGVLTAsLTIWKKM | phosphorylation down-regulates activity | 14766748 | SIGNOR-252538 |
| PRKCZ | BAX | Ser184 | VAGVLTAsLTIWKKM | phosphorylation down-regulates activity | 17525161 | SIGNOR-155111 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT | phosphorylation up-regulates → | BAX PSer184 | phosphorylation down-regulates ⊣ | BAX | 14766748 | SIGNOR-209651 |
| AKT1 | phosphorylation up-regulates → | BAX PSer184 | phosphorylation down-regulates ⊣ | BAX | 14766748 | SIGNOR-252538 |
| PRKCZ | phosphorylation up-regulates → | BAX PSer184 | phosphorylation down-regulates ⊣ | BAX | 17525161 | SIGNOR-155111 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AKT | phosphorylation → down-regulates activity | BAX | SIGNOR-209651 |
| AKT1 | phosphorylation → down-regulates activity | BAX | SIGNOR-252538 |
| PRKCZ | phosphorylation → down-regulates activity | BAX | SIGNOR-155111 |