| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK1 | KLC1 | Ser460 | YKACKVDsPTVTTTL | phosphorylation down-regulates | 21385839 | SIGNOR-172638 |
| Gbeta | KLC1 | – | phosphorylation down-regulates | 21385839 | SIGNOR-270072 | |
| MAPK3 | KLC1 | Ser460 | YKACKVDsPTVTTTL | phosphorylation down-regulates | 21385839 | SIGNOR-172642 |
| ERK1/2 | KLC1 | – | phosphorylation down-regulates | 21385839 | SIGNOR-270176 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK1 | phosphorylation up-regulates → | KLC1 PSer460 | phosphorylation down-regulates ⊣ | KLC1 | 21385839 | SIGNOR-172638 |
| MAPK3 | phosphorylation up-regulates → | KLC1 PSer460 | phosphorylation down-regulates ⊣ | KLC1 | 21385839 | SIGNOR-172642 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK1 | phosphorylation down-regulates | KLC1 | SIGNOR-172638 |
| Gbeta | phosphorylation down-regulates | KLC1 | SIGNOR-270072 |
| MAPK3 | phosphorylation down-regulates | KLC1 | SIGNOR-172642 |
| ERK1/2 | phosphorylation down-regulates | KLC1 | SIGNOR-270176 |
