| Name | LRP1 |
| ID | Q07954 |
| Role | substrate |
| Enzymatic Domains |
LDL-receptor class A 1 25-66 PROSITE-ProRule
LDL-receptor class A 2 70-110 PROSITE-ProRule
EGF-like 1 111-149 PROSITE-ProRule
EGF-like 2; calcium-binding 150-189 PROSITE-ProRule
EGF-like 3 474-520 PROSITE-ProRule
EGF-like 4 803-843 PROSITE-ProRule
LDL-receptor class A 3 852-892 PROSITE-ProRule
LDL-receptor class A 4 893-933 PROSITE-ProRule
LDL-receptor class A 5 934-973 PROSITE-ProRule
LDL-receptor class A 6 974-1013 PROSITE-ProRule
LDL-receptor class A 7 1013-1053 PROSITE-ProRule
LDL-receptor class A 8 1060-1099 PROSITE-ProRule
LDL-receptor class A 9 1102-1142 PROSITE-ProRule
LDL-receptor class A 10 1143-1182 PROSITE-ProRule
EGF-like 5 1183-1222 PROSITE-ProRule
EGF-like 6 1223-1262 PROSITE-ProRule
EGF-like 7 1536-1579 PROSITE-ProRule
EGF-like 8 1846-1887 PROSITE-ProRule
EGF-like 9 2155-2195 PROSITE-ProRule
EGF-like 10 2478-2518 PROSITE-ProRule
LDL-receptor class A 11 2522-2563 PROSITE-ProRule
LDL-receptor class A 12 2564-2602 PROSITE-ProRule
LDL-receptor class A 13 2603-2641 PROSITE-ProRule
LDL-receptor class A 14 2642-2690 PROSITE-ProRule
LDL-receptor class A 15 2694-2732 PROSITE-ProRule
LDL-receptor class A 16 2732-2771 PROSITE-ProRule
LDL-receptor class A 17 2772-2814 PROSITE-ProRule
LDL-receptor class A 18 2816-2855 PROSITE-ProRule
LDL-receptor class A 19 2856-2899 PROSITE-ProRule
LDL-receptor class A 20 2902-2940 PROSITE-ProRule
EGF-like 11 2941-2981 PROSITE-ProRule
EGF-like 12; calcium-binding 2982-3022 PROSITE-ProRule
EGF-like 13 3290-3331 PROSITE-ProRule
LDL-receptor class A 21 3332-3371 PROSITE-ProRule
LDL-receptor class A 22 3372-3410 PROSITE-ProRule
LDL-receptor class A 23 3411-3450 PROSITE-ProRule
LDL-receptor class A 24 3451-3491 PROSITE-ProRule
LDL-receptor class A 25 3492-3533 PROSITE-ProRule
LDL-receptor class A 26 3534-3572 PROSITE-ProRule
LDL-receptor class A 27 3573-3611 PROSITE-ProRule
LDL-receptor class A 28 3611-3649 PROSITE-ProRule
LDL-receptor class A 29 3652-3692 PROSITE-ProRule
LDL-receptor class A 30 3693-3733 PROSITE-ProRule
LDL-receptor class A 31 3739-3778 PROSITE-ProRule
EGF-like 14 3781-3823 PROSITE-ProRule
EGF-like 15 3824-3861 PROSITE-ProRule
EGF-like 16 4147-4183 PROSITE-ProRule
EGF-like 17 4196-4232 PROSITE-ProRule
EGF-like 18 4232-4268 PROSITE-ProRule
EGF-like 19 4268-4304 PROSITE-ProRule
EGF-like 20 4304-4340 PROSITE-ProRule
EGF-like 21 4340-4375 PROSITE-ProRule
EGF-like 22 4373-4409 PROSITE-ProRule |
View in  |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCA | LRP1 | Ser4520 | GGHGSRHsLASTDEK | phosphorylation up-regulates | 15272003 | SIGNOR-127207 |
| PRKACA | LRP1 | Ser4520 | GGHGSRHsLASTDEK | phosphorylation up-regulates activity | 11158305 | SIGNOR-250000 |
| PRKCA | LRP1 | Ser4517 | LYMGGHGsRHSLAST | phosphorylation up-regulates | 15272003 | SIGNOR-126958 |
| SRC | LRP1 | Tyr4507 | TNFTNPVyATLYMGG | phosphorylation up-regulates activity | 12789267 | SIGNOR-101535 |
| PRKCA | LRP1 | Ser4523 | GSRHSLAsTDEKREL | phosphorylation up-regulates | 15272003 | SIGNOR-127211 |
| SRC | LRP1 | Tyr4473 | VEIGNPTyKMYEGGE | phosphorylation up-regulates | 18381291 | SIGNOR-178159 |
| PRKCA | LRP1 | Thr4460 | GFQHQRMtNGAMNVE | phosphorylation up-regulates | 15272003 | SIGNOR-127215 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCA | phosphorylation up-regulates → | LRP1 PSer4520 | phosphorylation up-regulates → | LRP1 | 15272003 | SIGNOR-127207 |
| PRKACA | phosphorylation up-regulates → | LRP1 PSer4520 | phosphorylation up-regulates → | LRP1 | 11158305 | SIGNOR-250000 |
| PRKCA | phosphorylation up-regulates → | LRP1 PSer4517 | phosphorylation up-regulates → | LRP1 | 15272003 | SIGNOR-126958 |
| SRC | phosphorylation up-regulates → | LRP1 PTyr4507 | phosphorylation up-regulates → | LRP1 | 12789267 | SIGNOR-101535 |
| PRKCA | phosphorylation up-regulates → | LRP1 PSer4523 | phosphorylation up-regulates → | LRP1 | 15272003 | SIGNOR-127211 |
| SRC | phosphorylation up-regulates → | LRP1 PTyr4473 | phosphorylation up-regulates → | LRP1 | 18381291 | SIGNOR-178159 |
| PRKCA | phosphorylation up-regulates → | LRP1 PThr4460 | phosphorylation up-regulates → | LRP1 | 15272003 | SIGNOR-127215 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKCA | phosphorylation → up-regulates | LRP1 | SIGNOR-127207 |
| PRKACA | phosphorylation → up-regulates activity | LRP1 | SIGNOR-250000 |
| PRKCA | phosphorylation → up-regulates | LRP1 | SIGNOR-126958 |
| SRC | phosphorylation → up-regulates activity | LRP1 | SIGNOR-101535 |
| PRKCA | phosphorylation → up-regulates | LRP1 | SIGNOR-127211 |
| SRC | phosphorylation → up-regulates | LRP1 | SIGNOR-178159 |
| PRKCA | phosphorylation → up-regulates | LRP1 | SIGNOR-127215 |