| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CyclinB/CDK1 | FOXM1 | Ser251 | MIQFAINsTERKRMT | phosphorylation up-regulates | 19737929 | SIGNOR-216833 |
| HIPK2 | FOXM1 | – | phosphorylation up-regulates activity | 30609136 | SIGNOR-278944 | |
| CDK2 | FOXM1 | Thr611 | ETLPISStPSKSVLP | phosphorylation up-regulates activity | 15024056 | SIGNOR-250731 |
| GSK3B | FOXM1 | Ser474 | S-->A | phosphorylation down-regulates quantity by destabilization | 26912724 | SIGNOR-277208 |
| SRC | FOXM1 | – | phosphorylation up-regulates activity | 19665017 | SIGNOR-279117 | |
| CyclinB/CDK1 | FOXM1 | Thr611 | ETLPISStPSKSVLP | phosphorylation up-regulates | 19737929 | SIGNOR-216837 |
| PLK1 | FOXM1 | Ser730 | VLDTMNDsLSKILLD | phosphorylation up-regulates | 19737929 | SIGNOR-187888 |
| CDK4 | FOXM1 | Thr627 | TPESWRLtPPAKVGG | phosphorylation up-regulates | 22094256 | SIGNOR-177263 |
| CDK1 | FOXM1 | Ser251 | MIQFAINsTERKRMT | phosphorylation up-regulates | 19737929 | SIGNOR-187876 |
| CDK4 | FOXM1 | Thr620 | SKSVLPRtPESWRLT | phosphorylation up-regulates | 22094256 | SIGNOR-177259 |
| CHEK1 | FOXM1 | – | phosphorylation up-regulates activity | 23706767 | SIGNOR-280224 | |
| MELK | FOXM1 | – | phosphorylation up-regulates activity | 23404835 | SIGNOR-278412 | |
| PLK1 | FOXM1 | Ser739 | SKILLDIsFPGLDED | phosphorylation up-regulates | 19737929 | SIGNOR-187892 |
| CDK4 | FOXM1 | – | phosphorylation up-regulates | 22094256 | SIGNOR-177266 | |
| CDK4 | FOXM1 | Thr611 | ETLPISStPSKSVLP | phosphorylation up-regulates | 22094256 | SIGNOR-177255 |
| CHEK2 | FOXM1 | Ser376 | PLLPRVSsYLVPIQF | phosphorylation up-regulates | 17101782 | SIGNOR-150746 |
| CDK4 | FOXM1 | Ser4 | sPRRPLIL | phosphorylation up-regulates | 22094256 | SIGNOR-177251 |
| CDK1 | FOXM1 | Thr611 | ETLPISStPSKSVLP | phosphorylation up-regulates | 19737929 | SIGNOR-187880 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CyclinB/CDK1 | phosphorylation up-regulates → | FOXM1 PSer251 | phosphorylation up-regulates → | FOXM1 | 19737929 | SIGNOR-216833 |
| CDK2 | phosphorylation up-regulates → | FOXM1 PThr611 | phosphorylation up-regulates → | FOXM1 | 15024056 | SIGNOR-250731 |
| GSK3B | phosphorylation up-regulates → | FOXM1 PSer474 | phosphorylation down-regulates ⊣ | FOXM1 | 26912724 | SIGNOR-277208 |
| CyclinB/CDK1 | phosphorylation up-regulates → | FOXM1 PThr611 | phosphorylation up-regulates → | FOXM1 | 19737929 | SIGNOR-216837 |
| PLK1 | phosphorylation up-regulates → | FOXM1 PSer730 | phosphorylation up-regulates → | FOXM1 | 19737929 | SIGNOR-187888 |
| CDK4 | phosphorylation up-regulates → | FOXM1 PThr627 | phosphorylation up-regulates → | FOXM1 | 22094256 | SIGNOR-177263 |
| CDK1 | phosphorylation up-regulates → | FOXM1 PSer251 | phosphorylation up-regulates → | FOXM1 | 19737929 | SIGNOR-187876 |
| CDK4 | phosphorylation up-regulates → | FOXM1 PThr620 | phosphorylation up-regulates → | FOXM1 | 22094256 | SIGNOR-177259 |
| PLK1 | phosphorylation up-regulates → | FOXM1 PSer739 | phosphorylation up-regulates → | FOXM1 | 19737929 | SIGNOR-187892 |
| CDK4 | phosphorylation up-regulates → | FOXM1 PThr611 | phosphorylation up-regulates → | FOXM1 | 22094256 | SIGNOR-177255 |
| CHEK2 | phosphorylation up-regulates → | FOXM1 PSer376 | phosphorylation up-regulates → | FOXM1 | 17101782 | SIGNOR-150746 |
| CDK4 | phosphorylation up-regulates → | FOXM1 PSer4 | phosphorylation up-regulates → | FOXM1 | 22094256 | SIGNOR-177251 |
| CDK1 | phosphorylation up-regulates → | FOXM1 PThr611 | phosphorylation up-regulates → | FOXM1 | 19737929 | SIGNOR-187880 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CyclinB/CDK1 | phosphorylation → up-regulates | FOXM1 | SIGNOR-216833 |
| HIPK2 | phosphorylation → up-regulates activity | FOXM1 | SIGNOR-278944 |
| CDK2 | phosphorylation → up-regulates activity | FOXM1 | SIGNOR-250731 |
| GSK3B | phosphorylation down-regulates quantity by destabilization | FOXM1 | SIGNOR-277208 |
| SRC | phosphorylation → up-regulates activity | FOXM1 | SIGNOR-279117 |
| CyclinB/CDK1 | phosphorylation → up-regulates | FOXM1 | SIGNOR-216837 |
| PLK1 | phosphorylation → up-regulates | FOXM1 | SIGNOR-187888 |
| CDK4 | phosphorylation → up-regulates | FOXM1 | SIGNOR-177263 |
| CDK1 | phosphorylation → up-regulates | FOXM1 | SIGNOR-187876 |
| CDK4 | phosphorylation → up-regulates | FOXM1 | SIGNOR-177259 |
| CHEK1 | phosphorylation → up-regulates activity | FOXM1 | SIGNOR-280224 |
| MELK | phosphorylation → up-regulates activity | FOXM1 | SIGNOR-278412 |
| PLK1 | phosphorylation → up-regulates | FOXM1 | SIGNOR-187892 |
| CDK4 | phosphorylation → up-regulates | FOXM1 | SIGNOR-177266 |
| CDK4 | phosphorylation → up-regulates | FOXM1 | SIGNOR-177255 |
| CHEK2 | phosphorylation → up-regulates | FOXM1 | SIGNOR-150746 |
| CDK4 | phosphorylation → up-regulates | FOXM1 | SIGNOR-177251 |
| CDK1 | phosphorylation → up-regulates | FOXM1 | SIGNOR-187880 |
