| Name | PDE4C |
| ID | Q08493 |
| Role | substrate |
| Enzymatic Domains |
PDEase 312-641 PROSITE-ProRule |
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|
| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK1 | PDE4C | Ser641 | YQSKIPRsPSDLTNP | phosphorylation down-regulates | 11030732 | SIGNOR-83187 |
| PKA | PDE4C | Ser14 | GEGAEACsRLSRSRG | phosphorylation up-regulates activity | 12023945 | SIGNOR-273938 |
| PKA | PDE4C | Ser14 | GEGAEACsRLSRSRG | phosphorylation up-regulates activity | 12023945 | SIGNOR-275987 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK1 | phosphorylation up-regulates → | PDE4C PSer641 | phosphorylation down-regulates ⊣ | PDE4C | 11030732 | SIGNOR-83187 |
| PKA | phosphorylation up-regulates → | PDE4C PSer14 | phosphorylation up-regulates → | PDE4C | 12023945 | SIGNOR-273938 |
| PKA | phosphorylation up-regulates → | PDE4C PSer14 | phosphorylation up-regulates → | PDE4C | 12023945 | SIGNOR-275987 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK1 | phosphorylation down-regulates | PDE4C | SIGNOR-83187 |
| PKA | phosphorylation → up-regulates activity | PDE4C | SIGNOR-273938 |
| PKA | phosphorylation → up-regulates activity | PDE4C | SIGNOR-275987 |