| Name | PDE4D |
| ID | Q08499 |
| Role | substrate |
| Enzymatic Domains |
PDEase 386-715 PROSITE-ProRule |
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|
| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKACA | PDE4D | – | phosphorylation up-regulates | 8663227 | SIGNOR-42515 | |
| MAPK1 | PDE4D | Ser715 | YQSTIPQsPSPAPDD | phosphorylation down-regulates | 10022832 | SIGNOR-64326 |
| MAPK1 | PDE4D | Ser715 | YQSTIPQsPSPAPDD | phosphorylation down-regulates | 16973330 | SIGNOR-149570 |
| PKA | PDE4D | Ser125 | CRAMDRTsYAVETGH | phosphorylation up-regulates activity | 12023945 | SIGNOR-275988 |
| MAPK1 | PDE4D | Ser715 | YQSTIPQsPSPAPDD | phosphorylation down-regulates | 10828059 | SIGNOR-77571 |
| PKA | PDE4D | Ser125 | CRAMDRTsYAVETGH | phosphorylation up-regulates activity | 12023945 | SIGNOR-273939 |
| Gbeta | PDE4D | – | phosphorylation down-regulates | 10828059 | SIGNOR-270069 | |
| MAPK3 | PDE4D | Ser715 | YQSTIPQsPSPAPDD | phosphorylation down-regulates | 10828059 | SIGNOR-77578 |
| MAPK1 | PDE4D | – | phosphorylation down-regulates | 10828059 | SIGNOR-77574 | |
| ERK1/2 | PDE4D | – | phosphorylation down-regulates | 10828059 | SIGNOR-270174 | |
| MAPK1 | PDE4D | – | phosphorylation up-regulates | 10828059 | SIGNOR-77559 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK1 | phosphorylation up-regulates → | PDE4D PSer715 | phosphorylation down-regulates ⊣ | PDE4D | 10022832 | SIGNOR-64326 |
| MAPK1 | phosphorylation up-regulates → | PDE4D PSer715 | phosphorylation down-regulates ⊣ | PDE4D | 16973330 | SIGNOR-149570 |
| PKA | phosphorylation up-regulates → | PDE4D PSer125 | phosphorylation up-regulates → | PDE4D | 12023945 | SIGNOR-275988 |
| MAPK1 | phosphorylation up-regulates → | PDE4D PSer715 | phosphorylation down-regulates ⊣ | PDE4D | 10828059 | SIGNOR-77571 |
| PKA | phosphorylation up-regulates → | PDE4D PSer125 | phosphorylation up-regulates → | PDE4D | 12023945 | SIGNOR-273939 |
| MAPK3 | phosphorylation up-regulates → | PDE4D PSer715 | phosphorylation down-regulates ⊣ | PDE4D | 10828059 | SIGNOR-77578 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKACA | phosphorylation → up-regulates | PDE4D | SIGNOR-42515 |
| MAPK1 | phosphorylation down-regulates | PDE4D | SIGNOR-64326 |
| MAPK1 | phosphorylation down-regulates | PDE4D | SIGNOR-149570 |
| PKA | phosphorylation → up-regulates activity | PDE4D | SIGNOR-275988 |
| MAPK1 | phosphorylation down-regulates | PDE4D | SIGNOR-77571 |
| PKA | phosphorylation → up-regulates activity | PDE4D | SIGNOR-273939 |
| Gbeta | phosphorylation down-regulates | PDE4D | SIGNOR-270069 |
| MAPK3 | phosphorylation down-regulates | PDE4D | SIGNOR-77578 |
| MAPK1 | phosphorylation down-regulates | PDE4D | SIGNOR-77574 |
| ERK1/2 | phosphorylation down-regulates | PDE4D | SIGNOR-270174 |
| MAPK1 | phosphorylation → up-regulates | PDE4D | SIGNOR-77559 |