| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK1 | PDE4D | Ser715 | YQSTIPQsPSPAPDD | phosphorylation down-regulates | 10022832 | SIGNOR-64326 |
| MAPK1 | PDE4D | Ser715 | YQSTIPQsPSPAPDD | phosphorylation down-regulates | 16973330 | SIGNOR-149570 |
| MAPK1 | PDE4D | Ser715 | YQSTIPQsPSPAPDD | phosphorylation down-regulates | 10828059 | SIGNOR-77571 |
| MAPK3 | PDE4D | Ser715 | YQSTIPQsPSPAPDD | phosphorylation down-regulates | 10828059 | SIGNOR-77578 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK1 | phosphorylation up-regulates → | PDE4D PSer715 | phosphorylation down-regulates ⊣ | PDE4D | 10022832 | SIGNOR-64326 |
| MAPK1 | phosphorylation up-regulates → | PDE4D PSer715 | phosphorylation down-regulates ⊣ | PDE4D | 16973330 | SIGNOR-149570 |
| MAPK1 | phosphorylation up-regulates → | PDE4D PSer715 | phosphorylation down-regulates ⊣ | PDE4D | 10828059 | SIGNOR-77571 |
| MAPK3 | phosphorylation up-regulates → | PDE4D PSer715 | phosphorylation down-regulates ⊣ | PDE4D | 10828059 | SIGNOR-77578 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK1 | phosphorylation down-regulates | PDE4D | SIGNOR-64326 |
| MAPK1 | phosphorylation down-regulates | PDE4D | SIGNOR-149570 |
| MAPK1 | phosphorylation down-regulates | PDE4D | SIGNOR-77571 |
| MAPK3 | phosphorylation down-regulates | PDE4D | SIGNOR-77578 |
