| Name | ITK |
| ID | Q08881 |
| Role | kinase |
| Enzymatic Domains |
PH 4-111 PROSITE-ProRule
SH3 171-231 PROSITE-ProRule
SH2 239-338 PROSITE-ProRule
Protein kinase 363-615 PROSITE-ProRule |
View in  |
|
| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ITK | CD28 | Tyr191 | SRLLHSDyMNMTPRR | phosphorylation up-regulates | 22936936 | SIGNOR-198747 |
| ITK | CD28 | Tyr209 | TRKHYQPyAPPRDFA | phosphorylation up-regulates | 22936936 | SIGNOR-198751 |
| ITK | CD28 | Tyr191 | SRLLHSDyMNMTPRR | phosphorylation up-regulates | 8992971 | SIGNOR-45512 |
| ITK | CD28 | Tyr209 | TRKHYQPyAPPRDFA | phosphorylation up-regulates | 8992971 | SIGNOR-45516 |
| ITK | CD28 | Tyr218 | PPRDFAAyRS | phosphorylation up-regulates | 8992971 | SIGNOR-45520 |
| ITK | CD28 | Tyr191 | SRLLHSDyMNMTPRR | phosphorylation up-regulates activity | 8992971 | SIGNOR-251336 |
| ITK | CD28 | Tyr206 | PGPTRKHyQPYAPPR | phosphorylation up-regulates activity | 8992971 | SIGNOR-251334 |
| ITK | CD28 | Tyr218 | PPRDFAAyRS | phosphorylation up-regulates activity | 8992971 | SIGNOR-251337 |
| ITK | PLCG1 | – | phosphorylation up-regulates | 20519342 | SIGNOR-165803 | |
| ITK | TEC | Tyr206 | RLERGQEyLILEKND | phosphorylation up-regulates | 12573241 | SIGNOR-98090 |
| ITK | BMX | Tyr216 | SSTSLAQyDSNSKKI | phosphorylation up-regulates activity | 12573241 | SIGNOR-251331 |
| ITK | BMX | Tyr224 | DSNSKKIyGSQPNFN | phosphorylation up-regulates activity | 12573241 | SIGNOR-251332 |
| ITK | BTK | Tyr223 | LKKVVALyDYMPMNA | phosphorylation down-regulates activity | 12573241 | SIGNOR-251333 |
| ITK | ITK | Tyr180 | ETVVIALyDYQTNDP | phosphorylation up-regulates activity | 12842872 | SIGNOR-103170 |
| ITK | GNA13 | – | phosphorylation up-regulates activity | 23454662 | SIGNOR-279623 | |
| ITK | HAVCR2 | Tyr265 | IRSEENIyTIEENVY | phosphorylation up-regulates activity | 17069754 | SIGNOR-273644 |
| ITK | SIGLEC10 | Tyr597 | RHSTILDyINVVPTA | phosphorylation up-regulates | 11733002 | SIGNOR-112471 |
| ITK | SIGLEC10 | Tyr667 | ESQEELHyATLNFPG | phosphorylation up-regulates | 11733002 | SIGNOR-112475 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ITK | phosphorylation up-regulates → | CD28 PTyr191 | phosphorylation up-regulates → | CD28 | 22936936 | SIGNOR-198747 |
| ITK | phosphorylation up-regulates → | CD28 PTyr209 | phosphorylation up-regulates → | CD28 | 22936936 | SIGNOR-198751 |
| ITK | phosphorylation up-regulates → | CD28 PTyr191 | phosphorylation up-regulates → | CD28 | 8992971 | SIGNOR-45512 |
| ITK | phosphorylation up-regulates → | CD28 PTyr209 | phosphorylation up-regulates → | CD28 | 8992971 | SIGNOR-45516 |
| ITK | phosphorylation up-regulates → | CD28 PTyr218 | phosphorylation up-regulates → | CD28 | 8992971 | SIGNOR-45520 |
| ITK | phosphorylation up-regulates → | CD28 PTyr191 | phosphorylation up-regulates → | CD28 | 8992971 | SIGNOR-251336 |
| ITK | phosphorylation up-regulates → | CD28 PTyr206 | phosphorylation up-regulates → | CD28 | 8992971 | SIGNOR-251334 |
| ITK | phosphorylation up-regulates → | CD28 PTyr218 | phosphorylation up-regulates → | CD28 | 8992971 | SIGNOR-251337 |
| ITK | phosphorylation up-regulates → | TEC PTyr206 | phosphorylation up-regulates → | TEC | 12573241 | SIGNOR-98090 |
| ITK | phosphorylation up-regulates → | BMX PTyr216 | phosphorylation up-regulates → | BMX | 12573241 | SIGNOR-251331 |
| ITK | phosphorylation up-regulates → | BMX PTyr224 | phosphorylation up-regulates → | BMX | 12573241 | SIGNOR-251332 |
| ITK | phosphorylation up-regulates → | BTK PTyr223 | phosphorylation down-regulates ⊣ | BTK | 12573241 | SIGNOR-251333 |
| ITK | phosphorylation up-regulates → | ITK PTyr180 | phosphorylation up-regulates → | ITK | 12842872 | SIGNOR-103170 |
| ITK | phosphorylation up-regulates → | HAVCR2 PTyr265 | phosphorylation up-regulates → | HAVCR2 | 17069754 | SIGNOR-273644 |
| ITK | phosphorylation up-regulates → | SIGLEC10 PTyr597 | phosphorylation up-regulates → | SIGLEC10 | 11733002 | SIGNOR-112471 |
| ITK | phosphorylation up-regulates → | SIGLEC10 PTyr667 | phosphorylation up-regulates → | SIGLEC10 | 11733002 | SIGNOR-112475 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| ITK | phosphorylation → up-regulates | CD28 | SIGNOR-198747 |
| ITK | phosphorylation → up-regulates | CD28 | SIGNOR-198751 |
| ITK | phosphorylation → up-regulates | CD28 | SIGNOR-45512 |
| ITK | phosphorylation → up-regulates | CD28 | SIGNOR-45516 |
| ITK | phosphorylation → up-regulates | CD28 | SIGNOR-45520 |
| ITK | phosphorylation → up-regulates activity | CD28 | SIGNOR-251336 |
| ITK | phosphorylation → up-regulates activity | CD28 | SIGNOR-251334 |
| ITK | phosphorylation → up-regulates activity | CD28 | SIGNOR-251337 |
| ITK | phosphorylation → up-regulates | PLCG1 | SIGNOR-165803 |
| ITK | phosphorylation → up-regulates | TEC | SIGNOR-98090 |
| ITK | phosphorylation → up-regulates activity | BMX | SIGNOR-251331 |
| ITK | phosphorylation → up-regulates activity | BMX | SIGNOR-251332 |
| ITK | phosphorylation → down-regulates activity | BTK | SIGNOR-251333 |
| ITK | phosphorylation → up-regulates activity | ITK | SIGNOR-103170 |
| ITK | phosphorylation → up-regulates activity | GNA13 | SIGNOR-279623 |
| ITK | phosphorylation → up-regulates activity | HAVCR2 | SIGNOR-273644 |
| ITK | phosphorylation → up-regulates | SIGLEC10 | SIGNOR-112471 |
| ITK | phosphorylation → up-regulates | SIGLEC10 | SIGNOR-112475 |