| Name | ITK |
| ID | Q08881 |
| Role | substrate |
| Enzymatic Domains |
PH 4-111 PROSITE-ProRule
SH3 171-231 PROSITE-ProRule
SH2 239-338 PROSITE-ProRule
Protein kinase 363-615 PROSITE-ProRule |
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|
| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN11 | ITK | – | dephosphorylation down-regulates activity | 33624224 | SIGNOR-277174 | |
| BTK | ITK | Tyr180 | ETVVIALyDYQTNDP | phosphorylation up-regulates | 12573241 | SIGNOR-98036 |
| ITK | ITK | Tyr180 | ETVVIALyDYQTNDP | phosphorylation up-regulates activity | 12842872 | SIGNOR-103170 |
| LCK | ITK | Tyr512 | RFVLDDQyTSSTGTK | phosphorylation up-regulates | 9312162 | SIGNOR-251380 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| BTK | phosphorylation up-regulates → | ITK PTyr180 | phosphorylation up-regulates → | ITK | 12573241 | SIGNOR-98036 |
| ITK | phosphorylation up-regulates → | ITK PTyr180 | phosphorylation up-regulates → | ITK | 12842872 | SIGNOR-103170 |
| LCK | phosphorylation up-regulates → | ITK PTyr512 | phosphorylation up-regulates → | ITK | 9312162 | SIGNOR-251380 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPN11 | dephosphorylation → down-regulates activity | ITK | SIGNOR-277174 |
| BTK | phosphorylation → up-regulates | ITK | SIGNOR-98036 |
| ITK | phosphorylation → up-regulates activity | ITK | SIGNOR-103170 |
| LCK | phosphorylation → up-regulates | ITK | SIGNOR-251380 |