| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| BTK | ITK | Tyr180 | ETVVIALyDYQTNDP | phosphorylation up-regulates | 12573241 | SIGNOR-98036 |
| ITK | ITK | Tyr180 | ETVVIALyDYQTNDP | phosphorylation up-regulates activity | 12842872 | SIGNOR-103170 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| BTK | phosphorylation up-regulates → | ITK PTyr180 | phosphorylation up-regulates → | ITK | 12573241 | SIGNOR-98036 |
| ITK | phosphorylation up-regulates → | ITK PTyr180 | phosphorylation up-regulates → | ITK | 12842872 | SIGNOR-103170 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| BTK | phosphorylation → up-regulates | ITK | SIGNOR-98036 |
| ITK | phosphorylation → up-regulates activity | ITK | SIGNOR-103170 |